epitope mapping within an internal region of KV1.7 of human origin
recommended for detection of KV1.7 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
KV1.7 Background Information Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels which vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å-subunits (KVå), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV∫ subunits that modify the gating properties of the coexpressed KVå subunits. KV1.7 is a 456 amino acid voltage-gated K+ channel protein highly expressed in heart, skeletal muscle and kidney. The tail of KV1.7 is thought to modulate channel activity while the N-terminus may be important for the activation rate of the channel.
