SGK Antibody (84-O): sc-130402
- SGK Antibody (84-O) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant SGK of human origin
- recommended for detection of SGK of mouse, rat and human origin by WB, IF, IHC(P) and ELISA
- See SGK (G-4): sc-377360 for SGK antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SGK Antibody (84-O). This work is in progress.
SGK Antibody (84-O) is a mouse monoclonal IgG1 antibody that detects serum- and glucocorticoid-regulated kinase (SGK) in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SGK is a crucial serine/threonine protein kinase that plays a significant role in various cellular processes, including the regulation of ion channels, which are vital for maintaining cellular homeostasis and signaling. SGK (84-O) antibody helps researchers study the activation of potassium, sodium, and chloride channels, influencing cell survival, neuronal excitability, and renal sodium excretion. SGK′s structure includes a catalytic domain closely related to Akt1, highlighting SGK′s importance in the phosphoinositide 3-kinase signaling pathway. SGK is phosphorylated at Threonine-256 by 3-phosphoinositide-dependent protein kinase 1 (PDK1), which is essential for activation. Additionally, SGK expression is regulated by the adrenal corticosteroid hormone, Aldosterone, which enhances sodium transport by stimulating epithelial sodium channel activity. The SGK promoter features a glucocorticoid response element and an SP-1 regulatory element, making SGK a transcriptional target for p53, while also playing a role in the cellular response to hyperosmotic stress mediated by the p38 MAPK pathway. The human SGK gene is located on chromosome 6q23 and encodes a 431-amino acid protein, underscoring SGK′s significance in both physiological and pathological processes. Anti-SGK antibody (84-O) serves as an essential tool for researchers studying SGK′s intricate roles in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SGK Antibody (84-O) | sc-130402 | 100 µg/ml | $339.00 |