p-Tyk 2 Anticuerpo(Tyr 1054/1055): sc-11763

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Members of the Janus family of tyrosine kinases, including JAK1, JAK2 and Tyk 2, are characterized by the presence of a second kinase domain and the absence of SH2, SH3 and membrane spanning domains. The members of this family of tyrosine kinases play a critical role in coupling ligand binding of cytokine receptors to tyrosine phosphorylation. For instance, Tyk 2 couples IFNa/b binding to tyrosine phosphorylation of the proteins of the IFN-stimulated gene factor 3 complex. The Tyk and Jak family is involved in signal transduction in response to a specific family of cytokines, which consists of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6). Also, Tyk 2 has been shown to undergo intermolecular tyrosine phosphorylation after forming a homodimer. Mouse, rat and human Tyk 2 are activated by trans-phosphorylation on Tyr 1054 and Tyr 1055, which is dependent on JAK1 phosphorylation.