NAIP Anticuerpo(G-20): sc-11060

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NAIP (for neuronal apoptosis inhibitory protein) is a protein that inhibits apoptosis of neurons and other cell types and its gene is often mutated in severe cases of spinal muscular atrophy, a disease characterized by motor neuron degeneration (1-4). NAIP (mostly copy 2) mRNA transcripts are expressed in macrophage-rich tissues, such as spleen, lung, and liver and are abundant in primary macrophages (5). NAIP is expressed in mouse macrophages, in the cell line RAW 264.7, in anterior horn and motor cortex neurons of normal brains, in human fetal neurons and in adult choroid plexus cells (5,6). NAIP expression is increased after phagocytic events and during infection with L. pneumophila (5). There are at least three NAIP gene copies that encode full length mRNA and possible functional proteins, NAIP1, 2 and 3 (7).