DUSP24 Anticuerpo(S-17): sc-104230

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Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways, which are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DUSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DUSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP24, also designated MK-STYX, is likely a psuedophosphatase that is catalytically inactive. However, DUSP24 is consistently expressed in Ewing's sarcoma family tumors (ESFT) and may be a potential therapeutic target in that disease.