FGD5 Anticuerpo(C-15): sc-102518

---

FGD1 gene mutations result in faciogenital dysplasia, also known as FGDY or Aarskog syndrome, an X-linked developmental disorder that adversely affects the formation of multiple skeletal structures. Additional members of the FGD family include FGD2, FGD3, FGD4, FGD5 and FGD6. Also known as Zinc finger FYVE domain-containing protein 23, FGD5 is a 1,462 amino acid cytosolic protein that contains a DH domain, a FYVE-type zinc finger and two PH domains. FGD family members encode guanine nucleotide exchange factors that specifically activate the Rho GTPase Cdc42. All FGD proteins contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins also control essential signals required during embryonic development.