FBXO44 Anticuerpo(E-17): sc-101871

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F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBXO44 (F-box only protein 44), also known as FBG3, FBX30, FBX44, FBX6A or FBXO6A, is a 255 amino acid protein that contains one F-box domain and one FBA domain and functions as a component of the SCF complex. Expressed abundantly in kidney and brain and at lower levels in liver, heart and spleen, FBXO44 exists as multiple alternatively spliced isoforms and is thought to be involved in E3 ubiquitin ligase-related events throughout the cell.