p-PYK2 Anticuerpo(Tyr 402): sc-101790

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PYK2 (proline-rich tyrosine kinase 2), a putative member of the FAK family, exhibits 61% sequence identity with FAK within its kinase domain. Like FAK, PYK2 has been shown to be a cytoplasmic protein tyrosine kinase, which is a substrate for the intrinsic protein tyrosine kinase activity of pp60Src. PYK2 (also designated CAKb or RAFTK) is highly expressed in the central nervous system. PYK2 is rapidly phosphorylated on tyrosine residues in response to stimuli, which increases intracellular calcium levels and, in turn, activates members of the PKC family of kinases. Specifically, PYK2 is phosphorylated on Tyr 402 after stimulation with heregulin. This promotes the formation of a multiprotein complex that mediates the phosphorylation of p190 RhoGAP by Src. Activation of the PYK2 kinase leads to modulation of ion channel function and the activation of the MAPK signaling pathway. PYK2 also contains phosphorylation sites within the activation loop at Tyr 579 and Tyr 580 and on the potential Grb2-binding site at Tyr 881.