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p-PR Anticuerpo(Ser 190): sc-101786

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(Basado en el análisis de datos)

  • p-PR Antibody (Ser 190) is a rabbit polyclonal IgG provided at 100 µg/ml
  • epitope corresponding to phosphorylated Ser 190 of PR of human origin
  • recommended for detection of Ser 190 phosphorylated PR of h origin by WB, IP, IF and IHC(P)
 

Ver tambiénProgesterone Receptor Antibodies.

También verProgesterone Receptor Inhibitors for functional analysis of cellular responses to Progesterone Receptor.


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 Información sobre pedidos
Nombre del productoNúmero de catálogoUnidadPrecioCantidadAñadir 
p-PR Antibody (Ser 190) sc-101786 100 µg/ml $279
 
Especies Nombre del Gen Gene ID Ubicación en el cromosoma Numero de Acceso de Isoforma (ARNm) Número de Acceso de la Proteína Número OMIM™:
Humano PGR 5241 11q22.1 NM_000926 P06401
 607311
 

The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single copy of the PR gene. The first 164 amino acids of PR-B are absent in PR-A. Progesterone-bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms. Interestingly, the ID is functionally active only in PR-A and is necessary for steroid hormone transrepression by PR-A, suggesting that PR-A and PR-B may have different conformations in the cell. Phosphorylation of human PR occurs on at least nine serine residues. Phosphorylation of three of the residues is hormone-inducible (Ser 102, Ser 294 and Ser 345); the others are basal but hormone-stimulated .

p-PR Antibody (Ser 190) Data
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sc-101786
p-PR (Ser 190): sc-101786. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear staining.
sc-101786
p-PR (Ser 190): sc-101786. Western blot analysis of phosphorylated PR expression in untreated (A) and EGF-treated (B) COS7 whole cell lysates.
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