p-β-Amyloid Anticuerpo(Thr 668): sc-101632

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Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the ∫-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the ∫-Amyloid/Amyloid A4 protein, which plays a role in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. In humans, ∫-Amyloid can be phosphorylated at a variety of locations, such as Thr 668. This phosphyryloation can modulate the function of ∫-Amyloid)APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane- bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer’s disease patients.