Tom22 Anticuerpo(J-31): sc-101286

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The mitochondrial preprotein translocases of the outer membrane (Tom) is a multisubunit protein complex that facilitates the import of nucleus-encoded precursor proteins across the mitochondrial outer membrane (1). The Tom machinery consists of import receptors for the initial binding of cytosolically synthesized preproteins and a general import pore (GIP) for the membrane translocation of various preproteins into the mitochondria (2). The import receptors include Tom20 and Tom22, which form a heteromeric receptor complex that initiates the insertion of newly synthesized proteins into the outer membrane and then directs the precursor protein into the GIP (3,4). In yeast, Tom22 is the essential component of the import receptor complex, as it functions as a receptor for the preproteins and serves as a docking point for both Tom20 and the GIP (5,6). Tom22 directly associates with Tom40, the major component of the GIP, and forms a stable interaction between the two core complexes (6). This interactions facilitates the fluid movement of preproteins into the mitochondria (7). Structural features of Tom22 include an N-terminal negatively charged region exposed to the cytosol, a C-terminal innermembrane space region with little negative charge, and a putative transmembrane region (8). The gene encoding human Tom22 maps to chromosome 22q12-q13 (9,10).