USP48 Antibody (5C2): sc-100635

USP48 Antibody (5C2) is a mouse monoclonal IgG1 kappa light chain antibody that detects the USP48 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). USP48 (5C2) antibody is available as the non-conjugated form. USP48, also known as ubiquitin specific peptidase 48 or USP31, is a crucial component of the ubiquitin-proteasome system, which regulates various cellular processes by controlling protein degradation. This 1,035 amino acid protein is widely expressed and belongs to the peptidase C19 family, featuring three DUSP domains and one ubiquitin-like domain. USP48 functions primarily as a deubiquitinating enzyme, cleaving ubiquitin residues from ubiquitinylated proteins and ubiquitin-fused precursors, thus preventing their degradation by the proteasome. This activity is vital for maintaining cellular homeostasis and regulating key signaling pathways, including the NFκB pathway, by reversing the ubiquitination of proteins such as TRAF2 and TRAF6. Notably, USP48 is subject to alternative splicing, resulting in the expression of seven distinct isoforms, which may have unique regulatory roles in various biological contexts.

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USP48 Antibody (5C2) References:

1. Human and mouse proteases: a comparative genomic approach.  |  Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.  |  Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
3. Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis.  |  Lockhart, PJ., et al. 2004. DNA Seq. 15: 9-14. PMID: 15354349
4. PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.  |  Hatano, Y., et al. 2004. Neurology. 63: 1482-5. PMID: 15505170
5. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.  |  Tzimas, C., et al. 2006. Cell Signal. 18: 83-92. PMID: 16214042
6. Ubiquitin: tool and target for intracellular NF-kappaB inhibitors.  |  Wullaert, A., et al. 2006. Trends Immunol. 27: 533-40. PMID: 16982211
7. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes.  |  Wilkinson, KD. 1997. FASEB J. 11: 1245-56. PMID: 9409543

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USP48 Antibody (5C2) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-USP48 Antibody (5C2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USP48 Antibody (5C2) Specifications

Alternate Product Name: USP48

Product Clone Name: 5C2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 110-220

Epitope Target: USP48

Epitope Species: human

Product Reactivity/Detection: USP48

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for USP48 Antibody (5C2): N/A