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Toxins

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NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free basesc-208657A dopaminergic neurotoxin which reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys. NÚMERO DE CAS 28289-54-5

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Hydrochloridesc-206178A dopaminergic neurotoxin that causes a severe and irreversible Parkinsonian condition in humans and monkeys. NÚMERO DE CAS 23007-85-4

Bis(methylthio)gliotoxin (FR-49175)sc-201027Bis(methylthio)gliotoxin (FR-49175) is analog of gliotoxin shown to inhibit PAF-induced platelet aggregation and speed up PAF hydrolysis. NÚMERO DE CAS 74149-38-5

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5’-Iodoresiniferatoxinsc-2020245'-Iodoresiniferatoxin is an inhibitor of VR.

Azaspiracid-1sc-202482Azaspiracid-1 is an activator of JNK (c-Jun-N-terminal kinase)and caspases. It is also a cellular growth inhibitor and inducer of cytoskeletal alterations. NÚMERO DE CAS 214899-21-5

Aaptaminesc-202899Aaptamine is a spongean alkaloid that can activate the p21 promoter in the absence of p53 and can function as a proteasome inhibitor. NÚMERO DE CAS 85547-22-4

6’-Iodoresiniferatoxinsc-2020256'-Iodoresiniferatoxin is a high affinity TRPV1 (VR1) vanilloid receptor partial agonist.

Aconitinesc-202441A lipid-soluble and potent neurotoxin that activates voltage gated sodium channels. NÚMERO DE CAS 302-27-2

β-Amanitinsc-202860A toxic constituent of Amanita phalloides that inhibits eukaryotic RNA polymerase II and III and bacterial RNA polymerase thus inhibtting protein synthesis. NÚMERO DE CAS 21150-22-1

α-BUNGAROTOXINsc-202897α-Bungarotoxin is an scetylcholine receptor (AChR) inhibitor which blocks neuromuscular transmission via irreversible binding to the acetylcholine receptor to the motor end-plate. NÚMERO DE CAS 11032-79-4

1
α-Amanitinsc-202440α-Amanitin is the major toxic bicyclic octapeptide of the Amanita phalloides mushroom. This compound is an inhibitor of RNA polymerase II. NÚMERO DE CAS 23109-05-9

6
α-Sarcin, Aspergillus giganteussc-204427Native α-sarcin from Aspergillus giganteus. α-Sarcin is a ribosome-inactivating protein that has been demonstrated to induce apoptosis in rhabdomyosarcoma cells. Suitable for induction of apoptosis and inhibition of protein synthesis. NÚMERO DE CAS 86243-64-3

α-Zearalenolsc-202388A synthetic derivative of the mycotoxin Zearalenone. Produces estrogenic effects three times more potently than the parent compound. NÚMERO DE CAS 36455-72-8

Cytochalasin E, Aspergillus clavatussc-202561Cytochalasin E, Aspergillus clavatus is fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. NÚMERO DE CAS 36011-19-5

4
Alternariolsc-202923A mycotoxin that has been shown to inhibit the short action current across transepithelial sodium pumps. Also demonstrates the ability to have acute cytotoxic effects on cells. NÚMERO DE CAS 641-38-3

6-Hydroxydopamine hydrochloridesc-2034826-Hydroxydopamine hydrochloride is a selective catecholaminergic neurotoxin. NÚMERO DE CAS 28094-15-7

(-)-Huperzine Asc-200183(-)-Huperzine A is an inhibitor of AChE, and an antagonist of NMDA receptors. (-)-Huperzine A protects against glutamate-mediated excitotoxicity. NÚMERO DE CAS 102518-79-6

Fumonisin B1sc-201395Fumonisin B1 is a fungal metabolite that inhibits serine/threonine phosphatases. It also inhibits LASS (ceramide synthase), induces apoptosis. NÚMERO DE CAS 116355-83-0

1
Azaspiracid-2sc-202483Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. NÚMERO DE CAS 265996-92-7

Mastoparan (Vespula lewisii)sc-200831Mastoparan (Vespula lewisii) has been shown to be capable of directly activating G proteins by a mechanism analogous to that of G protein-coupled receptors. Also found to stimulate insulin release by pancreatic islets. NÚMERO DE CAS 72093-21-1

Azaspiracid-3sc-202484Modulator of intracellular cAMP (cyclic adenosine monophosphate), calcium and pH levels. NÚMERO DE CAS 265996-93-8

β-Bungarotoxinsc-202981A snake venom neuro toxin with phospholipase A2 activity shown to inhibit Acetylcholine release presynaptically at neuromuscular junctions and specificity for the cholinergic nerve terminals at the CNS. NÚMERO DE CAS 12778-32-4

Fusicoccinsc-200754Fusicoccin is a toxin originally extracted from Fusicoccum amygdali Del., and is shown to be an activator of H+-ATPase. NÚMERO DE CAS 20108-30-9

1
Cobratoxin Purifiedsc-361980 NÚMERO DE CAS 12584-83-7

Citreoviridinsc-202545A mycotoxin that was initially isolated from Penicillium citreoviride. Has been found to potently inhibit mitochondrial ATPases via uncompetitive inhibition of ATP hydrolysis. NÚMERO DE CAS 25425-12-1

Convulxinsc-202554Heterodimeric C-type lectin. Activates mammalian platelets via binding and clustering of p62/GPVI-receptors under physiological conditions. NÚMERO DE CAS 37206-04-5

Cylindrospermopsinsc-203014A cyanotoxin natural product. Inhibits protein synthesis. Decreases cellular GSH levels. Toxicity produced by cytochrome p450-generated metabolites. NÚMERO DE CAS 143545-90-8

Deepoxy-deoxynivalenol solutionsc-234521 NÚMERO DE CAS 88054-24-4

Rottlerinsc-3550Rottlerin is an inhibitor of eEF2K, PKCδ, PKCα, PKCβ, PKCε, PKCη and PKCζ, but with significantly reduced potency. It is also a HERG activator. NÚMERO DE CAS 82-08-6

4
Deoxynivalenolsc-204711A mycotoxin usually produced by Fusarium species. Shown to be an immunosuppressant at high concentrations and an immunostimulant at low concentrations. NÚMERO DE CAS 51481-10-8

Diphtheria Toxin, CRM Mutantsc-203924A compound that does not have NAD:EF2 ADP-ribosyltransferase activity due to an amino acid substitution of glycine to glutamic acid. NÚMERO DE CAS 92092-36-9

1
Cantharidinsc-201321Cantharidin is a small molecule herbicide and potent inhibitor of PP2A (IC50=40 nM). NÚMERO DE CAS 56-25-7

4
Exotoxin A, Pseudomonas aeruginosasc-203949Exotoxin A, Pseudomonas aeruginosa is a bacterial toxin originally derived from Pseudomonas aeruginosa that has been shown to arrest protein synthesis and cause apoptosis. NÚMERO DE CAS 91262-95-2

F16sc-202604Cell-permeable, fluorogenic, delocalized lipophilic cationic compound. Mitochondrial toxin with the dual ability to induce apoptosis as well as necrosis in tumor cells. NÚMERO DE CAS 36098-33-6

Fusarenon Xsc-235234 NÚMERO DE CAS 23255-69-8

Fumigaclavine Asc-203051Ergot alkaloid. Mycotoxin. NÚMERO DE CAS 6879-59-0

Gonyautoxin 2/3 Epimerssc-203433Neurotoxin. Epimeric mixture of gonyautoxin 2 and gonyautoxin 3, equally potent and selective Na+ channel blockers. NÚMERO DE CAS 60508-89-6 (GTXII); 60537-65-7 (GTXIII)

Latrunculin A, Latrunculia magnificasc-202691Latruculin A is a macrolide marine toxin, binds and stabilizes G-actin, inhibiting polymerization into F-actin microfilaments. NÚMERO DE CAS 76343-93-6

9
Fumonisin B2sc-201393Fumonisin B2 is a structural analog of fumonisin B1 noted to inhibit LASS (sphingosine acyltransferase). NÚMERO DE CAS 116355-84-1

Latrunculin B, Latrunculia magnificasc-203318Latrunculin B is a structurally unique marine toxin that Inhibits actin polymerization and disrupts microfilament organization and processes. NÚMERO DE CAS 76343-94-7

Moniliforminsc-359847Moniliformin is a mycotoxin formed in many cereals. NÚMERO DE CAS 31876-38-7

Moniliformin sodium saltsc-203140Mycotoxin NÚMERO DE CAS 71376-34-6

Kaliotoxinsc-362754 NÚMERO DE CAS 145199-73-1

Nonivamidesc-202735An agonist of the TRPV1 receptor, structurally related to Capscaicin. Stimulates afferent neurons with about half the potency of Capscaicin. NÚMERO DE CAS 2444-46-4

Ochratoxin Asc-202749A mycotoxin with nephrotoxic and teratogenic effects. Inhibits phenylalanyl-tRNA synthetases and phenylalanine-recognizing enzymes. Oxidative damage is identified as a partial mediator of toxic effects. Demonstrated to increase ATP-dependent Ca2+ pump activity in renal cortex endoplasmic reticulum. NÚMERO DE CAS 303-47-9

Ochratoxin Bsc-202258The non-chlorinated much less potent and active analogue of Ochratoxin A (sc-202749). NÚMERO DE CAS 4825-86-9

Paraherquamide Asc-202275Mycotoxin related to the indole tremorgenic mycotoxins. Selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors. NÚMERO DE CAS 77392-58-6

Pectenotoxin-2sc-203181Potent disruptor of actin cytoskeleton in living cells. Forms 1:1 complexes with monomeric actin and caps actin filaments. NÚMERO DE CAS 97564-91-5

Pertussis Toxin (islet-activating protein)sc-200837Shown to be a toxin that catalyzes ADP-ribosylation of a protein in membrane preparation. Also reported to block the ability of inhibitory hormones to reduce adenylate cyclase activity. NÚMERO DE CAS 82248-93-9

1
Pertussis Toxin, A Protomer, Bordetella pertussissc-222149Enzymatic component of the holotoxin. Has both NAD-glycohydrolase and ADP-ribosyltransferase activities. Inhibits neutrophil-mediated inflammation in vivo via its ADP-ribosylation activity.

Pertussis Toxin, B Oligomer, Bordetella pertussissc-222150The pentameric cell-binding component that is responsible for binding of the holotoxin to eukaryotic cell surfaces, facilitating entry of the A protomer into receptive cells.

Phalloidin CruzFluor™ 350 Conjugatesc-363789Phalloidin CruzFluor™ 350 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 353 nm, λem 442 nm

Phalloidin CruzFluor™ 405 Conjugatesc-363790Phalloidin CruzFluor™ 405 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 400 nm, λem 421 nm

Okadaic Acidsc-3513Okadaic acid is a potent and selective inhibitor of PP1 and PP2A-C (PP2A phosphatases); reduces outgrowth of PC12 cells. NÚMERO DE CAS 78111-17-8

10
Phalloidin CruzFluor™ 488 Conjugatesc-363791Phalloidin CruzFluor™ 488 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 493 nm, λem 517 nm

Phalloidin CruzFluor™ 514 Conjugatesc-363792Phalloidin CruzFluor™ 514 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 520 nm, λem 547 nm

Phalloidin CruzFluor™ 532 Conjugatesc-363793Phalloidin CruzFluor™ 532 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 542 nm, λem 558 nm

Phalloidin CruzFluor™ 555 Conjugatesc-363794Phalloidin CruzFluor™ 555 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 556 nm, λem 574 nm

Phalloidin CruzFluor™ 594 Conjugatesc-363795Phalloidin CruzFluor™ 594 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 590 nm, λem 618 nm

Lipopolysaccharide, Salmonella typhimuriumsc-221857Lipopolysaccharide, Salmonella typhimurium stimulates the activity of inducible nitric oxide synthase. Also induces apoptosis in mouse thymus and swine lymphocytes. Contaminants: protein 1.5%; nucleic acid; 1.2%.

Phalloidin CruzFluor™ 633 Conjugatesc-363796Phalloidin CruzFluor™ 633 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 634 nm, λem 649 nm

Phalloidin CruzFluor™ 647 Conjugatesc-363797Phalloidin CruzFluor™ 647 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 650 nm, λem 665 nm

Phalloidin CruzFluor™ 680 Conjugatesc-363798Phalloidin CruzFluor™ 680 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 681 nm, λem 698 nm

Phalloidin CruzFluor™ 700 Conjugatesc-363799Phalloidin CruzFluor™ 700 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 692 nm, λem 708 nm

Phalloidin CruzFluor™ 750 Conjugatesc-363800Phalloidin CruzFluor™ 750 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 752 nm, λem 778 nm

ω-Agatoxin TKsc-200190ω-Agatoxin TK is a selective blocker of the P-type Ca2+ channel. NÚMERO DE CAS 158484-42-5

Phalloidin CruzFluor™ 790 Conjugatesc-363801Phalloidin CruzFluor™ 790 Conjugate is a fluorescent dye that selectively binds to F-actins. λex 787 nm, λem 808 nm

Phalloidinsc-202763A heptapeptide phallotoxin isolated from Amanita phalloides. Stabilizes filamentous F-actin, interfering with normal cell functioning and inducing cell death. NÚMERO DE CAS 17466-45-4

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Phomopsin Asc-202282Shown to be a potent microtubule inhibitor. Also reported to suppress vinblastine binding and enhance colchicine binding to tubulin. NÚMERO DE CAS 64925-80-0

Roquefortine Csc-202323Roquefortine C is a potential neurotoxin and a mycotoxin produced by Penicillium roqueforti and P. crustosum. Shown to activate and inhibit detoxification enzymes P-gp and cytochrome P450-3A, respectively. NÚMERO DE CAS 58735-64-1

2
Sapintoxin Dsc-203254Fluorescent, highly potent phorbol ester. Useful for membrane studies. NÚMERO DE CAS 80998-07-8

Stachybotrylactamsc-202345Unusual spirodihydrobenzofuranlactam mycotoxin shows immunosuppressant and weak HIV protease activity. NÚMERO DE CAS 163391-76-2

Sterigmatocystinsc-222329Inhibitor of DNA synthesis. Mycotoxin produced by strains of the common molds. Induces sister chromatid exchanges in bone marrow cells of mice. Causes necrosis. NÚMERO DE CAS 10048-13-2

Syringomycin Esc-215939Syringomycin E (SR-E) is a phytotoxin of the cyclic lipodepsinonapeptides class composed of a 3-hydroxy fatty acid tail attached to a polar peptide head that contains nine amino acid residues. It is a potent biosurfactant, which is toxic to many plants and fungi and is implicated as a virulence factor in several major plant diseases such as holcus spot disease of maize and bacterial canker of stone fruits. NÚMERO DE CAS 124888-22-8

Tentotoxin, Alternaria alternatasc-222343Tentoxin is a phytotoxic cyclic tetrapeptide which is an inhibitor of chloroplast F1-ATPase (CF1). NÚMERO DE CAS 28540-82-1

Territrem Bsc-203293A tremorgenic mycotoxin originally derived from a rice culture of Aspergillus terreus and has been shown to be a potent inhibitor of acetylcholinesterase. NÚMERO DE CAS 70407-20-4

Tetanolysinsc-222345A cytolysin from Clostridium tetani that can be used to permeabilize mammalian cells to macromolecules . Similar to Streptolysin O, but has greater purity and control over pore size. Tetanolysin is reported to induce pores of 20-50 nm, which can be controlled by varying tetanolysin concentration. NÚMERO DE CAS 61614-31-1

Tetanus Toxin, C-Fragment, Clostridium tetanisc-222346Tetanus Toxin, C-Fragment, Clostridium tetani is the C-terminal binding portion of the heavy chain of tetanus toxin. It is useful for binding studies.

Tetanus Toxin, Clostridium tetanisc-222347This is produced by the anaerobic bacillus Clostridium tetani. The Tetanus toxin is one of the most deadlytoxins known. It is composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge. It also binds GT1b ganglioside in a hemagglutination assay. NÚMERO DE CAS 676570-37-9

Curvularinsc-202113Shown to be a fungal metabolite and a potent mycotoxin. Also has been reported to inhibit inducible nitric-oxide synthase-dependent NO production. NÚMERO DE CAS 10140-70-2

Tetanus Toxoid, Clostridium tetanisc-222348Tetanus Toxoid, Clostridium tetani is prepared with formaldehyde inactivation of the tetanus toxin. It has been determined to be non-toxic by an LD50 assay in mice.

Thaxtomin Asc-358702Phytotoxin. Causes plant cell necrosis at nanomolar concentrations. Demonstrated to be produced by bacterial nitric oxide synthases (NOS). NÚMERO DE CAS 122380-18-1

Thioacetamidesc-213031A hepatotoxin and a carcinogen. An additive in enantioselective reduction of β-keto esters with immobilized bakers' yeast. NÚMERO DE CAS 62-55-5

Toxin A, Clostridium difficilesc-222361Toxin A, Clostridium difficile is an inhibitor of Cdc42, Rac and Rhodopsin.

Toxin B, Clostridium difficilesc-222362This is a high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, via glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, which leads to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositiol 4,5-bisphosphate. It may also block serotonin release, and stimulate the production of phospholipases C and D. Due to its ability to affect depolymerization of the cytoskeleton, toxin B has been shown to inhibit biphasic muscle contraction. This toxin does not require assistance to permeabilize cells, unlike Exoenzyme C3. It is cytotoxic as determined in a cell rounding assay using human foreskin cells.

(+)-Tubocurarine dichloridesc-202845Induces neuromuscular block through interaction with acetylcholine receptor. NÚMERO DE CAS 57-94-3

Lipopolysaccharide, Ultra Pure, Salmonella minnesota R595 (Re)sc-221858Lipopolysaccharide, Ultra Pure, Salmonella minnesota R595 (Re) is a phenol-petroleum ether extracted lipopolysaccharide (LPS) containing 0.3% proteins.

Phalloidin Oleatesc-222153Phalloidin oleate is a semi-synthetic derivative of Phalloidin (sc-202763) that is about 100-fold more cell-permeable than Phalloidin with similar acting binding properties.

MALP-2sc-221869Isolated from Mycoplasma fermentans which corresponds to the originally isolated isomer. Expresses potent endotoxin-like activity and approaches in certain experimental systems the toxicity of LPS. Signalling, unlike that of LPS, is not transduced via TLR4, but is induced via TLR2 and TLR6 signalling. Specific activity is ~2x108units/mg. One unit is defined as the dilution giving half maximal release of nitric oxide from C3H/HeJ mouse peritoneal exudate cells in the standard assay. For more information about MALP-2 see www.malp-research.de.