Leukotriene Receptor Ligands

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NOMBRE DEL PRODUCTO	NÚMERO DE CATÁLOGO	DESCRIPCIÓN	MENCIONES	CLASIFICACIÓN
BAY-u 9773	sc-203835	A cysteinyl leukotriene receptor antagonist which displays equal affinity towards CysLT1 and CysLT2 receptors. NÚMERO DE CAS 154978-38-8
Cinalukast	sc-203893	Potent, selective leukotriene D4 receptor antagonist; orally active NÚMERO DE CAS 128312-51-6
Dapsone	sc-203023	Leukotriene B4 (LTB4) antagonist. Inhibits LTB4 induced lysozyme release. NÚMERO DE CAS 80-08-0
FPL 55712	sc-203583	A LTD4, LTE4, LTF4, and LTC4 competitive antagonist. Shown to also be an SRS-A antagonist as well. NÚMERO DE CAS 40786-08-1
Leukotriene B4-dimethyl Amide	sc-200702	Leukotriene B4-dimethyl Amide is an inhibitor of P2Y7. NÚMERO DE CAS 83024-92-4
LY 171883	sc-203120	LY 171883 is a leukotriene D4 antagonist that has been shown to displace oleic acid binding to FABPs. Reported to contain structural similarity to fatty acids. NÚMERO DE CAS 88107-10-2
LY-255283	sc-201346	LY-255283 is a hydroxyacetophenone that acts as a leukotriene B4 receptor antagonist which specifically binds to the P2Y7 (BLT1)and LTB4R2 (BLT2) receptors. NÚMERO DE CAS 117690-79-6
MK-571	sc-201340	MK-571 has been shown to be a leukotriene receptor ligand which specifically inhibits LTD4 binding to CysLT1 receptors. Also reported as an anti-inflammatory agent. NÚMERO DE CAS 115104-28-4
ONO 1078	sc-204148	CysLT1 antagonist. Downplays contraction of smooth airway muscle, microvascular leakage into airways and eosinophil infiltration. Potential to decrease symptoms of bronchial asthma. NÚMERO DE CAS 103177-37-3
REV-5901	sc-205488	REV-5901 is a dual activity CysLT1 Receptor (LTD4) inhibitor and 5-LO (5-lipoxygenase) inhibitor (IC50=6 μM). NÚMERO DE CAS 101910-24-1
SR 2640 Hydrochloride	sc-204902	Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo. NÚMERO DE CAS 105350-26-3
U-75302	sc-201331	U-75302 is a selective P2Y7 (leukotriene B4 BLT1) antagonist, Ki=159 nM for inhibition of [3H]-LTB4 binding to guinea pig lung membranes. NÚMERO DE CAS 119477-85-9	1
Verlukast	sc-213152	A receptor antagonist for the treatment of respiratory diseases. NÚMERO DE CAS 120443-16-5
Captopril Disulfide	sc-211011	Captopril Disulfide is a reversible and competitive inhibitor of LTA4 hydrolase (IC50=11 µM). Captopril has been shown to be an of angiotensin converting enzyme-1 (ACE1), but not ACE2(IC50 = 22 nM). NÚMERO DE CAS 64806-05-9
LTA4 (Leukotriene A4 methyl ester)	sc-201039	LTA4 (Leukotriene A4 methyl ester) has been shown to act as a substrate for LTA4H and LTC4 synthase and plays a central role in transcellular leukotriene and lipoxin biosynthesis, and to mobilize Ca2+ in human neutrophils. NÚMERO DE CAS 73466-12-3
LTB3 (Leukotriene B3)	sc-201041	LTB3 (Leukotriene B3) is a proinflammatory agent that causes aggregation of murine polymorphonuclear leukocytes. Generated by 5-lipoxygenase from phospholipase-released arachidonic acid. NÚMERO DE CAS 88099-35-8
LTB4 (Leukotriene B4)	sc-201043	LTB4 (Leukotriene B4) is a potent chemokine with roles in inflammation, immunology, the nervous system, brain and skin. Suggested to attenuate effects as an PPARα activator. NÚMERO DE CAS 71160-24-2
LTC4 (Leukotriene C4)	sc-201046	LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, induces microvascular permeability and mucus secretion in airways, and enhances growth of human airway epithelial cells. NÚMERO DE CAS 72025-60-6
5(S),6(R)-DiHETE	sc-200421	5(S),6(R)-DiHETE is an enzymatic metabolite of leukotriene A4 that functions as a CysLT1 Receptor (LTD4 (sc-201048) receptor) agonist. NÚMERO DE CAS 82948-88-7