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NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
AG-1296sc-200631AG-1296 is a potent and selective inhibitor of PDGFR kinase both in vitro and in Swiss 3T3 cells. AG-1296 also inhibits Bek (FGF receptor) tyrosine kinase and c-kit. NÚMERO DE CAS 146535-11-7

3
AEG 3482sc-202911AEG 3482 is an inhibitor of JNK (c-Jun N-terminal kinases). NÚMERO DE CAS 63735-71-7

1-(5-Isoquinolinesulfonyl)­-3-methylpiperazine, hydrochloridesc-213276A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases. NÚMERO DE CAS 141543-65-9

1-Naphthyl PP1sc-2037651-Naphthyl PP1 selectively inhibits c-Src family kinases v-Src and c-Fyn as well as c-Abl tyrosine kinase (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). NÚMERO DE CAS 221243-82-9

A 419259 trihydrochloridesc-361094A 419259 trihydrochloride has been found to be an apoptosis inducing agent that inhibits Src family kinases (c-Src). NÚMERO DE CAS 364042-47-7

Casein Kinase II Inhibidor III, TBCAsc-203869A cell-permeable tetrabrominated cinnamic acid compound that acts as an ATP-competitive and potent inhibitor of Casein Kinase II with greater selectivity than DMAT and TBB (sc-202830). NÚMERO DE CAS 934358-00-6

1
Adaphostinsc-291833Adaphostin is a Bcr-Abl (the fusion protein of Bcr and c-Abl) tyrosine kinase inhibitor (IC50 = 14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines in vitro. NÚMERO DE CAS 241127-58-2

eEF-2 Kinase Inhibidor, NH125sc-203037EEF-2 Kinase Inhibitor, NH125 is a cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases and eukaryotic eEF2K/CaMKIII, while exhibiting much lower potency against PKC, PKA, and CaMKII. NÚMERO DE CAS 278603-08-0

1-(5-Isoquinolinesulfonyl)­piperazine Hydrochloridesc-213277Exhibits potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases. NÚMERO DE CAS 141543-63-7

Akt Inhibidorsc-221226Akt Inhibitor is a phosphatidylinositol ether analog that potently and selectively inhibits Akt. It moderately inhibits PI 3-kinase activity.

1
BI 78D3sc-203840BI 78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor. NÚMERO DE CAS 883065-90-5

1
Compound 401sc-202552Compound 401 is a potent, reversible, and ATP-competitive inhibitor of DNA-PK. Compound 401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts. NÚMERO DE CAS 168425-64-7

3
Cucurbitacin I, Cucumis sativus L.sc-203010Cucurbitacin I is shown to be a Stat3 and JAK2 inhibitor. Also reported to contain in vitro anti-proliferative activity against certain cancer cell lines. NÚMERO DE CAS 2222-07-3

AP 24534sc-362710AP 24534 is a small molecule, multi-target kinase inhibitor known to potently inhibit Bcr-Abl (the fusion protein of Bcr and c-Abl), Flk-1(VEGFR2) and FGFR. NÚMERO DE CAS 943319-70-8

Bcr-abl Inhibidor IIsc-221289Bcr-abl Inhibitor II is a cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of c-Abl and SRC kinases. NÚMERO DE CAS 607702-99-8

1-(5-Isoquinolinylsulfonyl)­-3-methylpiperazine dihydrochloridesc-213278A lesser potent inhibitor of phosphokinase C than H-7. NÚMERO DE CAS 140663-38-3

1,2,3,4-Tetrahydro Staurosporinesc-206233Staurosporine derivative used as an isoenzyme PKCå inhibitor and as an anticancer agent. NÚMERO DE CAS 220038-19-7

FGF Receptor Tyrosine Kinase Inhibidor IV, NP603sc-221613FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 is a cell-permeable SU6668 derivative that targets the ATP-binding pocket and inhibits the kinase activity of PDGFRβ, FGFR1 and VEGFR2.

KI 8751sc-203090KI 8751 is a selective inhibitor of Flk-1 (VEGFR-2) and c-Kit that has been shown to decrease cell proliferation and tumor growth. NÚMERO DE CAS 228559-41-9

1,3-Bis-(o-tert-butyldimethylsilyl)­-Fmoc-D-erythro-sphingosinesc-213489Protected Sphingosine.

PD 0325901sc-205427PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK1/2 in murine colon 26 tumors with an IC50 value of 0.33 nM. NÚMERO DE CAS 391210-10-9

3
Aurora Kinase Inhibidor IIsc-203827Aurora kinase inhibitor II is an anilinoquinazoline derivative that is both a potent and selective inhibitor of aurora kinase (ARK) and has the ability to permeate the cell membrane NÚMERO DE CAS 331770-21-9

JNK Inhibidor IXsc-202671JNK Inhibitor IX is a thienylnaphthamide compound that acts as a selective and potent inhibitor of the ATP binding sites of JNK2 and JNK3. NÚMERO DE CAS 312917-14-9

3
Aurora Kinase Inhibidor IIIsc-203828Aurora Kinase Inhibitor III is a cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of ARK-1. NÚMERO DE CAS 879127-16-9

2-Aminopurine Dihydrochloridesc-2015242-Aminopurine Dihydrochloride is a purine analog that acts as a protein kinase inhibitor. It acts as a mutagen, can override checkpoints of the cell cycle and induce S-phase arrested cells to enter mitosis incorrectly. NÚMERO DE CAS 76124-64-6

6
JNK Inhibidor Vsc-202672JNK Inhibitor V is a potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50 = 150nM, hJNK2: IC50 = 220nM and hJNK3: IC50 = 70 nM). NÚMERO DE CAS 345987-15-7

JNK Inhibidor VIIIsc-202673JNK Inhibitor VIII has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of JNK and JNKAR1. NÚMERO DE CAS 894804-07-0

2-Azido-1-pivaloyl-D-erythro-Sphingosinesc-206402A derivative of Sphingosine. A selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Also inhibits calmodulin-dependent enzymes. NÚMERO DE CAS 114275-41-1

PKC-412sc-200691PKC-412 has been reported to be an antiproliferatiive agent which inhibits protein kinase C. Additionally PKC-412 has been shown to increase endothelial nitric oxide (NO) synthase expression and NO production. NÚMERO DE CAS 120685-11-2

Tyrene CR4sc-296677Tyrene CR4 potently inhibits JAK2 and Bcr-Abl (the fusion protein of Bcr and c-Abl) by targeting their kinase activities.

2,3,6-Trideoxy-Ins(1,4,5)­P3. 6Nasc-220787Exhibits relatively low ligand binding affinity to the Ins(1,4,5)P3 receptor of bovine adrenal cortex membranes and acts as a weak agonist in releasing calcium from saponin permeablized SH-Sy5Y human neurolastoma cells.

(2S,3R,4E)­-2-Azido-3-(tert-butyldimethylsilyl)­-1-pivaloyl-erythro-sphingosinesc-206567A derivative of Sphingosine. Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Inhibits calmodulin-dependent enzymes. NÚMERO DE CAS 114275-42-2

SU 5402sc-204308SU 5402 is an FGFR-specific tyrosine kinase inhibitor. Research shows that inhibition of FGFR results in the blocking of NVPs secretion and an increase of Ca2+. NÚMERO DE CAS 215543-92-3

SD 1008sc-358791JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. NÚMERO DE CAS 960201-81-4

CID 755673sc-205246CID 755673 is a selective and potent protein kinase D1-D3, PKC, CAK, PLK1 and CAMKIIα inhibitor that is reported to inhibit PKD-mediated protein transport. NÚMERO DE CAS 521937-07-5

(2S,3R,4E)­-2-Azido-3-(tert-butyldimethylsilyl)­-erythro-sphingosinesc-206568A derivative of Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Also inhibits calmodulin-dependent enzymes. NÚMERO DE CAS 114299-64-8

U0124sc-204934U0124 is an inactive analog of U0126. Used as a negative control. U0124 doesn’t inhibit MEK at concentrations up to 100 µM. NÚMERO DE CAS 108923-79-1

GSK 1059615sc-361198GSK 1059615, a pyridinylquinoline derivative, is a novel, ATP-competitive, and reversible class I PI 3-kinase inhibitor. GSK 1059615 is also an inhibitor of FRAP (mTOR). NÚMERO DE CAS 958852-01-2

CCT 137690sc-362722CCT137690 is a highly selective ARK-1, ARK-2, and ARK-3 inhibitor. NÚMERO DE CAS 1095382-05-0

Tyrphostin 9 (RG-50872, Malonaben, SF 6847)­sc-200568Tyrphostin 9 (RG-50872, Malonaben, SF 6847) is a PDGFR inhibitor and a calcium channel protein inhibitor. NÚMERO DE CAS 10537-47-0

3-O-(tert-Butyldimethylsilyloxy)­-2-Fmoc-erythro-sphingosinesc-206670A derivative of Sphingosine that is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. This compound does not inhibit protein kinase A or myosin light chain kinase, but does inhibit calmodulin-dependent enzymes. NÚMERO DE CAS 149035-77-8

3-O-(tert-Butyldimethylsilyloxy)­-erythro-sphingosinesc-206671This derivative of Sphingosine is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. This compound does not inhibit protein kinase A or myosin light chain kinase, although it inhibits calmodulin-dependent enzymes. NÚMERO DE CAS 137905-29-4

LY 294002, 4′-NH2sc-203121LY 294002, 4′-NH2 is a cell permeable 4′-amino derivative which inhibits the p110α, p110β, p110δ, and p110γ subunits of PI 3-kinase. NÚMERO DE CAS 942289-87-4

1
2-Bromoaldisinesc-2028802-Bromoaldisine is an inhibitor of the Raf/MEK-1/MAPK cascade (IC50= 539nM). NÚMERO DE CAS 96562-96-8

3,4-Dihydro-2H,10H-azepino[3,4-b]indole-1,5-dione Methanesulfonate Saltsc-206703A myt1 kinase inhibitor used in the treatment of proliferative diseases NÚMERO DE CAS 68724-84-5

LY-294,002 hydrochloridesc-215273LY-294,002 hydrochloride is a highly selective inhibitor of PI 3-kinase. It has also been reported to induce apoptosis in many cell types. NÚMERO DE CAS 934389-88-5

4-Amino-1-tert-butyl-3-(3-methylbenzyl)­pyrazolo[3,4-d]pyrimidinesc-206805A highly potent and uniquely specific tyrosine kinase inhibitor of v-Src tyrosine kinase. NÚMERO DE CAS 956025-83-5

Myricetinsc-203147Myricetin is a non-ATP competitive MEK1 inhibitor and ATP-competitive inhibitor of CKI, CKII, IR, MLCK, PKA, PKC, PI 3-kinaseα and PIM-1 . NÚMERO DE CAS 529-44-2

5'-Tosyl Thymidinesc-207074A nucleoside analogue used as inhibitors of thymidylate kinases NÚMERO DE CAS 7253-19-2

SP600125sc-200635SP600125 is a potent, selective and reversible inhibitor of JNK1, -2, and -3. An ATP competitive inhibitor with >20 fold selectivity versus a range of similar kinases. NÚMERO DE CAS 129-56-6

8
ZM 323881 hydrochloridesc-296861ZM 323881 hydrochloride is a potent receptor tyrosine kinase inhibitor of VEGFR-2 (Flk-1), PDGFR-beta, EGFR, and FGFR1 targets. NÚMERO DE CAS 324077-30-7

ZM-306416sc-200676ZM-306416 is a receptor tyrosine kinase inhibitor that has been shown to disrupt Flt and Flk activity. NÚMERO DE CAS 690206-97-4

7-Azaoxindolesc-207155Used for preparation of 3-(anilinomethylene) oxindoles and analogs as protein tyrosine kinase and protein serine/threonine kinase inhibitors. NÚMERO DE CAS 5654-97-7

SU 3327sc-296430SU 3327 is a selective inhibitor of JNK (c-Jun N-terminal kinase). NÚMERO DE CAS 40045-50-9

7,8-Dihydro-9-[2-(4-bromophenyl)­hydrazone]-5H-pyrido[3,2-b]azepine-6,9-dionesc-207184A GSK-3 inhibitor used NÚMERO DE CAS 676596-64-8

Rottlerinsc-3550Rottlerin is an inhibitor of eEF2K, PKCδ, PKCα, PKCβ, PKCε, PKCη and PKCζ, but with significantly reduced potency. It is also a HERG activator. NÚMERO DE CAS 82-08-6

4
Adenosine Kinase Inhibidorsc-202900Adenosine Kinase Inhibitor is an inhibitor of ADK (adenosine kinase (AK)). NÚMERO DE CAS 214697-26-4

AG 43sc-202916An inactive tyrphostin analogue that can be used a negative control parameter for other tyrphostins. NÚMERO DE CAS 5553-97-9

OM137sc-255403OM137 is an inhibitor of ARKs. It is a more potent inhibitor of ARK-2 compared with ARK-1 in vitro. NÚMERO DE CAS 292170-13-9

UCN-01sc-202376A Staurosporine (sc-3510) analogue that acts as a selective inhibitor of protein kinase C, potently inhibits MK2, induces UCN-01 G1 phase accumulation, dephosphorylates Rb and CDK2 proteins, and induces CDK inhibitor p21/Cip1/WAF1/Sdi1. NÚMERO DE CAS 112953-11-4

8
AG 556sc-202044Selectively inhibits EGF receptor kinase autophosphorylation (IC50 = 5 µM) over HER1/2 autophosphorylation. Also blocks LPS-induced TNF-α production. NÚMERO DE CAS 133550-41-1

Anomalin Asc-364099 NÚMERO DE CAS 548740-86-9

Apigeninsc-3529Apigenin inhibits MAP kinase-associated signal transduction pathways and proliferation of malignant tumor cells by causing G2/M arrest and induces morphological differentiation. NÚMERO DE CAS 520-36-5

9
Azido-erythro-sphingosinesc-207312A derivative of Sphingosine. A selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. Also inhibits calmodulin-dependent enzymes. NÚMERO DE CAS 103348-49-8

TC-A 2317 hydrochloridesc-363291TC-A 2317 hydrochloride is a potent and selective ARK-1 inhibitor. NÚMERO DE CAS 1245907-03-2

BAY R3401sc-239281A glycogen phosphorylase inhibitor shown to suppress hepatic glycogenolysis. NÚMERO DE CAS 100276-03-7

Tozasertibsc-358750Tozasertib is a potent pan-ARK inhibitor that favors ARK-1 over ARK-2 or ARK-3. NÚMERO DE CAS 639089-54-6

Lavendustin C methyl estersc-221838Lavendustin C methyl ester is an inhibitor of EGFR tyrosine kinase

LFM-A12sc-295360LFM-A12 is a potent and specific inhibitor of the EGFR tyrosine kinase in vitro. Has been shown to kill over 99% of human breast cancer cells in vitro by triggering apoptosis.

BC 11 hydrobromidesc-362712Selective urokinase (uPA) inhibitor which exhibits no activity at 8 other uPA related enzymes. NÚMERO DE CAS 443776-49-6

BIO-acetoximesc-361122BIO-acetoxime is a selective GSK-3α/β inhibitor with IC50 values of 0.01, 2.4, 4.3 and 63 µM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively. This compound has been shown to induce Wnt signaling and inhibits CD8+ T cell effector differentiation. NÚMERO DE CAS 667463-85-6

BTO-1sc-204206A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays. NÚMERO DE CAS 40647-02-7

3
CaMKP Inhibidorsc-203866Amino-naphthol sulfonic acid that acts as a competitive substrate inhibitor of Ca2+/CaMKP and the nuclear isoform CaMKP-N. Exhibits little activity against PP2B/CaN and PP2C NÚMERO DE CAS 52789-62-5

5-(5,6-dimethoxy-1H-benzimidazol-1-yl)­-3-[[4-(methylsulfonyl)­phenyl]methoxy]-2-thiophenecarboxamidesc-2051285-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide is a potent benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 μM (1), where IKK-ε is mostly expressed n immune cells and thought to play a role in immune response. NÚMERO DE CAS 916985-21-2

CAY10622sc-358882Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. It was inactive (showing greater then 100-fold selectivity) against an additional 44 kinases evaluated. NÚMERO DE CAS 1038549-25-5

Cell Sheet Migration Inhibidor, Locostatinsc-203875A cell-permeable and potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction. NÚMERO DE CAS 133812-16-5

2
PP 3sc-203213PP 3 is an inhibitor of EGFR tyrosine kinase, blocking autophosphorylation of the receptor. NÚMERO DE CAS 5334-30-5

Cell Sheet Migration Inhibidor, Negative Controlsc-221412A cell-permeable N-(butyryl)oxazolidinone compound which serves as a negative control for the Cell Sheet Migration Inhibitor. Displays little bioactivity during wound closure and cell proliferation studies.

(+)­-Aeroplysinin-1sc-202445(+)-Aeroplysinin-1 displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity. NÚMERO DE CAS 28656-91-9

Compound 56sc-203430The most potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor. NÚMERO DE CAS 171745-13-4

1
DAG Kinase Inhibidor IIsc-3551DAG Kinase Inhibitor is an inhibitor of DGK (Diacylglycerol kinase; DAG Kinase) and is useful for elucidating the roles of protein kinase C (PKC). This particular isoform, R59949, has been reported to potentially exhibit selective inhibition of DGK-α. NÚMERO DE CAS 120166-69-0

DNA-PK Inhibidor IIIsc-203928Cell-permeable, potent, selective, and an ATP-competitive inhibitor of DNA-PK and PI 3-Kinase catalytic subunit p110∫. NÚMERO DE CAS 404009-40-1

A 83-01sc-203791A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). This compound blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. NÚMERO DE CAS 909910-43-6

2
DNA-PK Inhibidor Vsc-203929Potent, selective and ATP-competitive inhibitor of DNA-PK (IC50 = 270 nM); inhibits PI 3-K catalytic subunit p110-isozymes. NÚMERO DE CAS 404009-46-7

DRBsc-200581DRB is shown to be an adenosine analogue which causes a premature termination of DNA transcription. Also reported to be a mixed-type inhibitor of casein kinase II. NÚMERO DE CAS 53-85-0

1
ER 27319 maleatesc-361177ER 27319 maleate is a selective Syk kinase inhibitor. NÚMERO DE CAS 201010-95-9

FCCPsc-203578Oxidative phosphorylation uncoupler in mitochondria. NÚMERO DE CAS 370-86-5

Flt-3 Inhibidorsc-203048Cell-permeable thienylcarboxamide that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor. NÚMERO DE CAS 301305-73-7

2
Flt-3 Inhibidor IIsc-363913 NÚMERO DE CAS 896138-40-2

Genistinsc-202168Isoflavone glycoside found in soy-based foods. An inactive analog of the PTK inhibitor Genistein. Can be used as a negative control for Genistein. Reportedly reduces bone loss in ovarectomized rats. NÚMERO DE CAS 529-59-9

Gold sodium thiomalatesc-203830A gold(I) compound that inhibits the activity of IKK (ID50 = 10.9 µM) and disrupts PB1 (Phox and Bem1p) domain-mediated interactions between Par6 and PKCi (IC50 ~ 1 µM) by modifying cysteine residues within the catalytic domain of IKK and the PB1 domain of PKCi. Inhibits PKCi-dependent Rac1 activation in A549 cells. NÚMERO DE CAS 12244-57-4

GSK 269962sc-363279GSK 269962 is a potent rho kinase (ROCK) inhibitor (IC50 = 1.6 and 4 nM for ROCK1 and ROCK2, respectively). This compound displays greater than 30-fold selectivity for ROCK against a panel of Ser/Thr kinases. NÚMERO DE CAS 850664-21-0

GSK 429286sc-361200GSK 429286 is a selective Rho-kinase(ROCK) inhibitor(IC50 = 14 nM) that has been shown to reverse adrenalin-induced contraction of the rat aortic ring. NÚMERO DE CAS 864082-47-3

GSK 650394sc-361201GSK 650394 is a glucocorticoid- and serum-regulated kinase 1 (SGK1) inhibitor which displays antiproliferative properties. NÚMERO DE CAS 890842-28-1

GTP 14564sc-203062A cell-permeable tricyclic benzofurano-indazolo compound which functions as a specific inhibitor of class III receptor tyrosine kinases. NÚMERO DE CAS 34823-86-4

2
GW441756 hydrochloridesc-215121A highly selective, potent TrkA kinase inhibitor which is orally active. IC50 = 2 nM. NÚMERO DE CAS 504433-24-3 (non-salt)

GW4869sc-218578A cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). This compound functions as an inhibitor, via a non-competitve manner. NÚMERO DE CAS 6823-69-4

H-1152 . dihydrochloridesc-203592H1152 dihydrochloride is a cell permeable, highly specific, and potent ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor. NÚMERO DE CAS 451462-58-1

H-1152 Dihydrochloridesc-207727H-1152 dihydrochloride is a ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK). NÚMERO DE CAS 871543-07-6

I-OMe-Tyrphostin AG 538sc-300821This product is an inhibitor of insulin growth factor 1 receptor protein tyrosine kinase.

Indirubin-3'-(2,3-dihydroxypropyl)­oximethersc-221752c-Src inhibitor blocking downstream STAT3 signalling. Also, induces apoptosis in human cancer cells.

Akt Inhibidor IVsc-203809Inhibitor of Akt protein kinase and reported to inhibit the ATP-binding site of kinase upstream of AKT and downstream of PI3K. NÚMERO DE CAS 681281-88-9

5
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibidorsc-204013Benzimidazole compound that acts as a cell-permeable, potent selective inhibitor of IL-1 kinases. Shown to exhibit little activity against a panel of 27 other kinases, including, but not limited to, Ick and src. NÚMERO DE CAS 509093-47-4

Akt Inhibidor IX, API-59CJ-OMesc-203810Buy Akt Inhibitor IX, API-59CJ-OMe, a cell-permeable ellipticine compound that selectively and potently induces apoptosis in human endometrial cancer cells that exhibit elevated Akt activity, but not on cells with low Akt activity. NÚMERO DE CAS 98510-80-6

2
IPA 3sc-204016A selective cell permeable Pak1 (group I p21-activated kinase) inhibitor which functions by inhibiting activators from binding to the active sites on the enzyme. NÚMERO DE CAS 42521-82-4

Akt Inhibidor Xsc-203811Akt Inhibitor X is a cell permeable, reversible, and selective inhibitory phenoxazine that suppresses the kinase reactivity of Akt by inhibiting its phosphorylation. NÚMERO DE CAS 925681-41-0

kb NB 142-70sc-358834kb NB 142-70 is a selective protein kinase D (PKD) inhibitor. Demonstrates a 7-fold increase in inhibition potency as an analog of CID 755673 (sc-205246).

Akt Inhibidor XIsc-221229Akt Inhibitor XI is a cell-permeable copper complex that interacts with both the PH and the kinase domains of Akt and potently inhibits its kinase activity.

KH CB19sc-362756

Akt Inhibidor XII, Isozyme-Selective, Akti-2sc-221230A cell-permeable Akt1/2 inhibitor-derived allosteric inhibitor pair with improved aqueous solubility and Akt2 selectivity. The inhibition is PH domain-dependent and non-competitive with ATP.

L-779,450sc-204046Potent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf. NÚMERO DE CAS 303727-31-3

Akt Inhibidor XIII, Isozyme-Selective, Akti2-1/2sc-221231Akt Inhibitor XIII, Isozyme-Selective, Akt1/2 inhibitor is a highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (sc-202048).

Linoleoyl Ethanolamide-d4sc-295362Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA). It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively. However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26. mg/kg). In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.-fold at 15 µM in a CB-receptor-independent manner. However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme. NÚMERO DE CAS 68171-52-8

LY 364947sc-203122A diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-β Receptor I kinase. NÚMERO DE CAS 396129-53-6

N-(2-Aminoethyl)­-5-chloroisoquinoline-8-sulfonamidesc-207901Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases. NÚMERO DE CAS 120615-25-0

N-(4-Pyridyl)­-N'-(2,4,6-trichlorophenyl)­ureasc-221970Potent, selective, and ATP-competitive inhibitor of Rho kinase. NÚMERO DE CAS 97627-27-5

N-[2-(p-Cinnamylamino)­ethyl]-5-isoquinolone Sulfonamidesc-207932Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase). NÚMERO DE CAS 130964-40-8

N-alpha-Benzoyl-L-argininamide hydrochloridesc-301278Shown to be a competitive inhibitor of urokinase and used as a substrate for cathepsin, NÚMERO DE CAS 4299-03-0

N-Boc-erythro-sphingosinesc-207996The N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. It does not inhibit protein kinase A or myosin light chain kinase. It inhibits calmodulin-dependent enzymes. NÚMERO DE CAS 609812-03-5

NFκB Activation Inhibidor VI, BOT-64sc-222062A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. NÚMERO DE CAS 113760-29-5

Palmitoyl-L-carnitine Chloridesc-205789Protein kinase inhibitor NÚMERO DE CAS 18877-64-0

Pamidronate disodium salt hydratesc-272006A bisphosphonate compound, which inhibits farnesyl diphosphate synthase and bone resorption. This compound stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. NÚMERO DE CAS 57248-88-1 (anhydrous)

PknG Inhibidorsc-222180PknG Inhibitor is a cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM). NÚMERO DE CAS 329221-38-7

PKR Inhibidor, Negative Controlsc-204201An oxindole compound that serves as a negative control for PKR Inhibitor. Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC50> 100 µM) or in rescuing PKR-dependent translation block. NÚMERO DE CAS 852547-30-9

PP1 Analog II, 1NM-PP1sc-203214Cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. NÚMERO DE CAS 221244-14-0

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ATM Kinase Inhibidorsc-202963ATM Kinase Inhibitor (KU 55933) is a cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated). NÚMERO DE CAS 587871-26-9

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Protein Kinase Inhibidor, DMAPsc-203220Puromycin analog inhibits protein kinases. Inhibits TNF-α upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. NÚMERO DE CAS 938-55-6

Pseudohypericinsc-202777A specific inhibitor of protein kinase C and D-β-H, an apoptosis inducer, and selective antagonist of corticotropin-releasing factor in murine models. NÚMERO DE CAS 55954-61-5

ATM/ATR Kinase Inhibidorsc-202964ATM/ATR Kinase Inhibitor was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR. NÚMERO DE CAS 905973-89-9

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psi-Tectorigeninsc-296865Shown to inhibit EGF-receptor Tyrosine Kinase leading to a block of phosphatidylinositol turnover. NÚMERO DE CAS 13111-57-4

Quercetagetinsc-204221A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase. NÚMERO DE CAS 90-18-6

rac-3-Octadecanamido-2-Methoxypropan-1-ol Phosphocholinesc-208288Shows strong inhibitory action against neoplastic cell growth in vitro. Inhibits Protein Kinase C. NÚMERO DE CAS 163702-19-0

Rho Kinase Inhibidor III, Rockoutsc-203237A cell permeable ATP-competitive Rho Kinase inhibitor observed to inhibit the blebbing and promote cell spreading. NÚMERO DE CAS 7272-84-6

Rho Kinase Inhibidor IVsc-222254Rho kinase inhibitor IV is a glycyl analog of Rho-Kinase Inhibitor which inhibits ROCK with an improved selectivity at 6 nM. NÚMERO DE CAS 913844-45-8

Avenanthramide-C methyl estersc-223786Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). NÚMERO DE CAS 955382-52-2

AZ 3146sc-361114AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor shown to display selectivity over 46 other kinases including Cdk1 and aurora kinase B. NÚMERO DE CAS 1124329-14-1

Rho Kinase Inhibidor Vsc-222255Rho Kinase Inhibitor V is a cell-permeable compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II and effectively inhibits phosphorylation of myosin light chain 2. NÚMERO DE CAS 1072906-02-5

Rp-8-CPT-cAMPSsc-215821Rp-8-CPT-cAMPS is a lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist). NÚMERO DE CAS 129735-01-9

RPI-1 sc-255524RP-1 is a potent and cell-permeable ATP-dependent inhibitor of Ret kinase, EGFR, and c-Met. NÚMERO DE CAS 269730-03-2

SKI IIsc-204286SKI II is a selective non-lipid inhibitor of sphingosine kinase; does not act at ATP-binding site. NÚMERO DE CAS 312636-16-1

Smad3 Inhibidor, SIS3sc-222318A cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. NÚMERO DE CAS 1009104-85-1

SR 3677 dihydrochloridesc-361364SR 3677 dihydrochloride is a selective and potent Rho-kinase inhibitor IC50 = 3 and 56 for ROCK2 and ROCK1, respectively). NÚMERO DE CAS 1072959-67-1

BML-257sc-200666BML-257 is an potent inhibitor of AKT1 translocation. BML-257 also inhibits HCV (hepatitis C virus) NS5B RNA-dependent RNA polymerase (RdRp) with an IC50 value of 79 μM. NÚMERO DE CAS 32387-96-5

Staurosporinesc-360258 NÚMERO DE CAS 62996-74-1

SU 4984sc-205977Inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1). Inhibits αFGF-induced tyrosine phosphorylation of ERK1 and ERK2 and the tyrosine phosphorylation of the PDGF receptor and the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. NÚMERO DE CAS 186610-89-9

SU6656sc-203286A potent, selective Src family kinase inhibitor known to inhibit c-Src, Fyn, c-Yes, Lyn, Lck and PDGF receptor kinase. NÚMERO DE CAS 330161-87-0

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BML-275sc-200689BML-275 is a cell-permeable pyrazolopyrimidine derivative that inhibits AMP Kinase in an ATP-competitive manner. Also inhibits morphogenetic protein signals. NÚMERO DE CAS 866405-64-3

Syk Inhibidor IV, BAY 61-3606sc-202351Cell-permeable imidazopyrimidine. Potent, ATP-competitive, reversible, and highly selective inhibitor of Syk and Syk-mediated cellular functions. NÚMERO DE CAS 732983-37-8

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(+/-)­-Taxifolin hydratesc-258192An antioxidant flavenoid. NÚMERO DE CAS 24198-97-8

TG 003sc-362808 NÚMERO DE CAS 719277-26-6

TGF-β RI Kinase Inhibidor IIIsc-204341A cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases. NÚMERO DE CAS 356559-13-2

TGF-β RI Kinase Inhibidor Vsc-203294A selective and reversible inhibitor, which suppresses TGF-β RI/ALK5 signaling. NÚMERO DE CAS 627536-09-8

TGF-β RI Kinase Inhibidor VIIIsc-203295A cell-permeable quinoxaline compound that acts as a potent, highly selective, ATP-competitive inhibitor against type I TGF-b receptor TbR-I/ALK5. NÚMERO DE CAS 356559-20-1

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Tpl2 Kinase Inhibidorsc-204351Tpl2 Kinase Inhibitor is a reversible naphthyridine ATP-competitive inhibitor of the enzyme Tpl2 kinase. The enzyme is a hematopoietically expressed serine-threonine kinase responsible for regulating tumor necrosis factor-α, toll-like receptor, and G protein–coupled receptor signaling. NÚMERO DE CAS 871307-18-5

BRD 7389sc-361129BRD 7389 has been found to inhibit p90 ribosomal S6 kinase (RSK). This compvound also upregulates insulin expression in terminally differentiated pancreatic &alpha-cells. NÚMERO DE CAS 376382-11-5

TX-1918sc-296676May be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eEF2-K (IC50 = 440 nM). Has been shown to inhibit other kinases at much higher concentrations (IC50 = 4.4, 44, 44, and 440 µM for Src, PKA, PKC, and EGFR-K, respectively). Reported to exhibit potent anti-tumor activity (EC50 = 2.07 and 230 µM in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥5000-fold) and hepato-toxicity (≥90-fold) when compared with another tyrphostin, AG 17 (sc-200568 and sc-200568). NÚMERO DE CAS 503473-32-3

Tyrphostin AG 1433sc-205984A specific and potent inhibitor of PDGF-β receptor kinase (IC50 = 5.0 µM) and of KDR/Flk-1/VEGF Receptor 2 (IC50 = 9.3 µM). Also acts as angiogenesis inhibitor. NÚMERO DE CAS 168836-03-1

UCN-02sc-202377Indolocarbazole isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Less selective than isomer UCN-01, UCN-02 exhibits comparable activity. NÚMERO DE CAS 121569-61-7

VEGF Inducer, GS4012sc-222411This is a cell-permeable pyridinyl-thioether compound which acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish as well as to stimulate tubule network formation (5 µg/ml) in HUVECs.

W-12, Hydrochloridesc-203309Calmodulin antagonist that inhibits myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase. NÚMERO DE CAS 89108-46-3

Y-27632 dihydrochloride monohydratesc-216067A potent, cell-permeable, ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor, that has also been shown to, ATP-competively, inhibit ROCK-II. NÚMERO DE CAS 331752-47-7

Dioctanoylglycolsc-203567Dioctanoylglycol is a diacylglycerol kinase (DGK) inhibitor. NÚMERO DE CAS 627-86-1

DMNBsc-202142DMNB, a cell-permeable vanillin derivative, is a potent inhibitor of DNA-PK, as well as an enzyme involved in non-homologous end joining. NÚMERO DE CAS 20357-25-9

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DNA-PK Inhibidor IIsc-202143DNA-PK Inhibitor II is shown to be a cell permeable potent antiproliferative agent, and reported to reduce lethal damage recovery in cells and DNA double strand break repair. NÚMERO DE CAS 154447-35-5

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Dorsomorphin dihydrochloridesc-361173Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin. NÚMERO DE CAS 866405-64-3

FAK Inhibidor 14sc-203950FAK Inhibitor 14 is a selective FAK (focal adhesion kinase) inhibitor that displays no significant activity for a range of other kinases. NÚMERO DE CAS 4506-66-5

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FPA 124sc-361179FPA 124 has been reported to be an Akt/PKB inhibitor that Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity. NÚMERO DE CAS 902779-59-3

GSK 690693sc-363280GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor. GSK 690693 has been shown to producte antiproliferative and apoptotic effects in tumor cell lines. NÚMERO DE CAS 937174-76-0

IKK-2 Inhibidor XIsc-359906A cell-permeable thiophenecarboxamide-ureido compound that exhibits potent, ATP-binding pocket-targeting inhibitor of IKK beta (IKK-2). NÚMERO DE CAS 354810-80-3

KU 60019sc-363284KU 60019 is a potent inhibitor of ATM kinase. KU 60019 has also been shown to Inhibit invasion and migration of human glioma cells in vitro. NÚMERO DE CAS 925701-46-8

LFM-A13sc-203623LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). LFM-A13 inhibits recombinant Btk. NÚMERO DE CAS 62004-35-7

Met Kinase Inhibidorsc-204801Met Kinase Inhibitor is a pyrrole indolinone compound acting as an ATP-competitive inhibitor of Met kinase activity. NÚMERO DE CAS 658084-23-2

MNSsc-202229MNS is a cell-permeable, cytotoxic β-nitrostyrene derivative which functions as a tyrosine kinase inhibitor that supresses human platelet aggregation. NÚMERO DE CAS 1485-00-3

PD 161570sc-361284PD 161570 is a selective FGFR inhibitor. PD 161570 inhibits FGFR receptor phosphorylation and growth of A121 cells in vitro. NÚMERO DE CAS 192705-80-9

PF 04217903 mesylatesc-363286PF 04217903 mesylate is a selective ATP-competitive Met inhibitor with IC50 of 4.8 nM. NÚMERO DE CAS 956906-93-7

PF 431396sc-362780PF 431396 is a dual inhibitor of FAK (focal adhesion kinase) (IC50 of 2 nM) and proline-rich tyrosine kinase 2 (PYK2) (IC50 of 11 nM). NÚMERO DE CAS 717906-29-1

PF 4708671sc-361288PF 4708671 is a membrane permeable p70 ribosomal S6 kinase inhibitor. This compound has been shown to decrease the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1. NÚMERO DE CAS 1255517-76-0

PF 573228sc-204179PF 573228 is a potent and selective FAK (focal adhesion kinase) inhibitor (IC50 = 4 nM). PF 573228 displays 50-250-fold selectivity over other protein kinases. NÚMERO DE CAS 869288-64-2

PHA 665752sc-203186PHA 665752 is a small molecule, ATP competitive inhibitor of the catalytic activity of Met tyrosine kinase and has apoptotic properties. NÚMERO DE CAS 477575-56-7

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PKR Inhibidorsc-204200PKR Inhibitor can inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. NÚMERO DE CAS 608512-97-6

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Polo-like Kinase Inhibidor IIIsc-203202Polo-like Kinase Inhibitor III is a cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against polo-like kinases (Plk). NÚMERO DE CAS 660868-91-7

Raf Kinase Inhibidor IVsc-203233Raf Kinase Inhibitor IV is a cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase. NÚMERO DE CAS 303727-31-3

Raf Kinase Inhibidor Vsc-222241Raf Kinase Inhibitor V is a cell-permeable azaindole compound that acts as a potent, ATP-site targeting and reversible inhibitor of Raf kinase. NÚMERO DE CAS 918505-84-7

SB 590885sc-363287SB 590885 is known to be a potent Raf-B inhibitor. NÚMERO DE CAS 405554-55-4

SBE 13 hydrochloridesc-362795SBE 13 hydrochloride is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). NÚMERO DE CAS 1052532-15-6

SL 0101-1sc-204287SL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). This product does not inhibit upstream kinases such as MEK, Raf and PKC. NÚMERO DE CAS 77307-50-7

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ST638sc-202344ST638 is a protein tyrosine kinase inhibitor (IC50 = 370 nM) that also inhibits PLD and HGF-induced MAP kinase activation. NÚMERO DE CAS 107761-24-0

STO-609sc-202820STO-609 is a selective ATP-competitive Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor. NÚMERO DE CAS 52029-86-4

SU 4312sc-200637SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR/Flk/Flt) inhibitor. NÚMERO DE CAS 5812-07-7

TCS 2002sc-359020TCS 2002 is a cell-permeable oxadiazolo-benzofuranylphenylsulfoxide that inhibits GSK-3β in a highly selective manner. NÚMERO DE CAS 1005201-24-0

Terreic Acidsc-200655Terreic acid is a metabolite that displays antibiotic properties, and has been found to inhibit the catalytic activity of Btk. NÚMERO DE CAS 121-40-4

Triciribinesc-200661Triciribine (also: API-2) is known to suppress the phosphorylation level and kinase activity of Akt. Selectively inhibits Akt1, Akt2, and Akt3 without inhibiting known upstream activators, PDK1 and PI 3-Kinase, of Akt. NÚMERO DE CAS 35943-35-2

TX-1123sc-296675May be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable, reversible and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as a kinase inhibitor for Src, eEF2-K, and PKA (IC50 = 2.2, 3.2, and 9.6 µM, respectively). Has been shown to inhibits EGFR-K and PKC, but only at much higher concentrations (IC50 = 320 µM). Reported to exhibit potent anti-tumor activity (EC50 = 3.66 and 39 µM in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 (sc-200568 and sc-200568A). NÚMERO DE CAS 157397-06-3