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NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
1-(5-Isoquinolinesulfonyl)-3-methylpiperazinesc-208552A less potent inhibitor of protein kinase C than H-7. NÚMERO DE CAS 84477-73-6

Indibulinsc-295179Indibulin is a microtubule destabilizer that blocks Tubulin polymerization. It also blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro. NÚMERO DE CAS 204205-90-3

17β-hydroxy Wortmanninsc-35874017β-hydroxy Wortmannin is an analog of wortmannin (sc-3505) that irreversibly binds PI 3-kinase and potently blocks fMLP-stimulated respiratory burst in neutrophils

Myoseverinsc-203146Myoseverin ia a microtubule-binding molecule that induces reversible fission of multinucleated myotubules into mononucleated fragments. NÚMERO DE CAS 267402-71-1

CI 898 trihydrochloridesc-203890CI 898 dihydrochloride is a dihydrofolate reductase (DHFR) inhibitor, displaying antineoplastic and antiprotozoal properties.

1-(8-Chloro-5-isoquinolinesulfonyl)piperazine, Dihydrochloridesc-206110Inhibits both Ca2+ dependent myosin phosphorylation by protein kinase C and MLC-Kinase. NÚMERO DE CAS 355115-40-1

Myoseverin Bsc-215407Myoseverin B is a new microtubule-binding molecule which acts reversibly on myoblast proliferation. It can be effectively used for inhibiting endothelial cell function and differentiation of progenitor cells. NÚMERO DE CAS 361431-27-8

CA-074sc-202513CA-074 is a potent and specific inhibitor of cathepsin B in vitro. NÚMERO DE CAS 134448-10-5

1-Allylcyclopropane-1-sulfonyl Chloridesc-206127A MEK inhibitor. Useful in the treatment of cancer and other hyperproliferative diseases. NÚMERO DE CAS 923032-59-1

CA-074 methyl estersc-214647CA-074 methyl ester is a cell-permeable analog of CA-074 (sc-202513) that acts as an irreversible cathepsin B inhibitor. NÚMERO DE CAS 147859-80-1

Axitinibsc-217679Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. Studied as an antitumor agent of various cell lines. NÚMERO DE CAS 319460-85-0

Everolimussc-218452Everolimus is a macrolide derived from Rapamycin (sc-3504), shown to inhibit cell proliferation induced by growth factors. Everolimus is a FRAP (mTOR) inhibitor. NÚMERO DE CAS 159351-69-6

Etoposide Phosphatesc-357357Etoposide Phosphate is a derivative of Etoposide (VP-16), which is a topoisomerase II inhibitor widely used as an apoptosis inducer. It inhibits DNA synthesis and activates p53. NÚMERO DE CAS 117091-64-2

1-Benzyl-4-cyano-4-phenylpiperidinesc-208614A piperidine derivative as calcium channel blockers. NÚMERO DE CAS 56243-25-5

Dehydrocostus Lactonesc-205643Dehydrocostus Lactone prevents TNF alpha induced degredation and phosphorylating thereby inhibiting NF kappa B activity. NÚMERO DE CAS 477-43-0

VULM 1457sc-204390VULM 1457 is an Acyl-CoA: cholesterol acyltransferase (ACAT) or SOAT inhibitor. VULM 1457 decreases cholesterol levels in the liver and plasma. NÚMERO DE CAS 228544-65-8

Benazepril hydrochloridesc-203526Benazepril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor. This prevents the catalytic conversion of angiotensin I to angiotensin II and in turn causes vasodilation and an increase in capillary blood volume. NÚMERO DE CAS 86541-74-4

1-Hydroxycyclopropanecarboxylic Acid Phosphate, Biscyclohexylamine Saltsc-213339A potent, reversible inhibitor of enzymes utilizing phosphoenolpyruvate (PEP), such as phosphoenolpyruvate carboxylase which catalyzes the carboxylation of PEP to produce oxaloacetate. NÚMERO DE CAS 94017-79-5

1-O-Acetyl-2,3,5-tri-O-benzoyl-α,β-D-ribofuranosesc-206190This compound inhibits neutrophil-keyhole limpet hemocyanin adhesion NÚMERO DE CAS 14215-97-5

NSC 66811sc-311507NSC 66811 is a potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function, leading to apoptosis. NÚMERO DE CAS 6964-62-1

1-Thio-β-D-glucose tetraacetatesc-205567Inhibits the Maillard reaction between glucose and glycine. NÚMERO DE CAS 19879-84-6

1,2-Isopropylidene Swainsoninesc-213452

1,4-Dichloro-7-isoquinolinesulfonyl Chloridesc-206252Intermediate of isoquinolinylguanidines as urokinase inhibitors. NÚMERO DE CAS 223671-80-5

1,4-Dideoxy-1,4-imino-D-arabinitol HClsc-220553A glycogen phosphorylase inhibitor. NÚMERO DE CAS 100937-52-8

1,5-Bis(4-Allyldimethylammoniumphenyl)pentan-3-one, Dibromidesc-206257A selective inhibitor of acetylcholinesterase. NÚMERO DE CAS 402-40-4

2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoic Acid Ethyl Estersc-206328Boronic acid ester derivative that inhibits hormone-sensitive lipase. NÚMERO DE CAS 346656-34-6

2-Acetamido-2-deoxy-6-O-(β-D-galactopyranosyl)-D-glucopyranosesc-216163An inhibitor of lectins. NÚMERO DE CAS 50787-10-5

2-Amino-4-isopropylamino-6-chlorotriazinesc-206379Has been shown to inhibit the growth of plants. NÚMERO DE CAS 6190-65-4

Proscillaridin Asc-202775Proscillaridin A is a cardiac glycoside which functions as a specific Na+/K+-ATPase inhibitor. At high concentrations Proscillaridin A can increase intracellular Ca2+ concentration, activate caspase-3 and induce apoptosis in human fibroblasts. NÚMERO DE CAS 466-06-8

2-Chloro-4-nitrophenyl-β-D-lactosidesc-220712A substrate used for the determination of cellobiohydrolase I. NÚMERO DE CAS 120583-41-7

2-Fluoropalmitic acidsc-202881Inhibitor of palmityl-CoA biosynthesis resulting in blockade of protein palmitoylation. NÚMERO DE CAS 89270-22-4

2-Hexynyl-5’-N-ethylcarboxamidoadenosinesc-206449This compound possesses high affinity to adenosine (A1 & A2) receptors, which inhibits radioligands from binding to these sites. NÚMERO DE CAS 141018-30-6

Cilazaprilsc-207435A monoethyl ester, which acts as an angiotensin-converting enzyme (ACE) inhibitor. The inhibitor functions by inhibiting the the ability of ACE to cleave bonds of angiotensin I and Hip-His-Leu. NÚMERO DE CAS 88768-40-5

2-Hydroxymyristic acidsc-2024012-Hydroxymyristic acid is an acid that has the capability to distinguish between myristoylation and palmitoylation, and is therefore able to inhibit protein myristoylation in cells. NÚMERO DE CAS 2507-55-3

5
GW2974sc-252869GW2974 is a dual selective inhibitor of EGFR and Neu (ErbB-2) receptor tyrosine kinases. This compound inhibits cancer line PC-3 growth. NÚMERO DE CAS 202272-68-2

HDS 029sc-203995HDS 029 is a potent inhibitor of EGFR and related kinases by inhibiting autophosphorylation of the receptor by the intrinsic tyrosine kinase. NÚMERO DE CAS 881001-19-0

2-Iodo-5'-ethylcarboxamido-2',3'-O-isopropylidineadenosinesc-216221 NÚMERO DE CAS 162936-24-5

2-n-Butylthiophenesc-204617Inhibitor of DMH-induced aberrant crypt formation in colon. NÚMERO DE CAS 1455-20-5

Lisinoprilsc-205378A potent angiotensin-converting enzyme inhibitor that inhibits the formation of angiotensin I with an IC50 value of 1.2 nM (ovine). NÚMERO DE CAS 76547-98-3

Nilvadipinesc-215567Nilvadipine is a potent calcium channel protein inhibitor and blocker (IC50 = 0.03 nM). NÚMERO DE CAS 75530-68-6

Moexipril hydrochloridesc-204095Moexipril hydrochloride is a potent inhibitor to the angiotensin converting enzyme, blocking the conversion of angiotensin I to angiotensin II. NÚMERO DE CAS 82586-52-5

2,4-Dibenzyl-5-oxothiadiazolidine-3-thionesc-213994A highly conserved, widely found and expressed Ser/Thr protein kinase that is active in the signal transduction cascades of multiple cellular processes. It is an analog of oxothadiazolidine-3-thione. NÚMERO DE CAS 72966-20-2

2,4-Diethylpyridine dicarboxylatesc-2024052,4-Diethylpyridine dicarboxylate is an inhibitor of HIF PHD. NÚMERO DE CAS 41438-38-4

2,4-Thiazolidinedionesc-216281Inhibitor of enzyme. NÚMERO DE CAS 2295-31-0

Moexiprilat Hydratesc-218866Moexiprilat hydrate is the hydrated active metabolite of moexipril. Moexiprilat is an inhibitor of angiotensin-converting enzyme (ACE). NÚMERO DE CAS 103775-14-0

2,6-Anhydro-3-deoxy-D-glycero-D-galacto-non-2-enoic Acidsc-206536Potential inhibitor of virus sialidase. NÚMERO DE CAS 188854-96-8

Perindoprilsc-205799Perindopril is a potent angiotensin converting enzyme (ACE) inhibitor (IC50 = 1.04 nM). NÚMERO DE CAS 82834-16-0

2'-(N-Methylanthraniloyl)guanosine 3',5'-Cyclicmonophosphate, Sodium Saltsc-206545Blue fluorescent derivative of cGMP, a useful substrate in the assay of cyclic nucleotide phosphodiesterases. Has been shown to inhibit calmodulin-dependent activation of cyclic nucleotide phosphodiestereases by peptide segments of HIV envelope glycoproteins. NÚMERO DE CAS 221905-46-0

2',3'-Dideoxyadenosinesc-2024062',3'-Dideoxyadenosine is an inhibitor of A cyclase. NÚMERO DE CAS 4097-22-7

Perindopril t-Butylamine Saltsc-208159Perindopril t-Butylamine Salt is an angiotensin-converting enzyme (ACE) inhibitor. Inhibition of this enzyme prevents the formation of angiotensin II from angiotensin I, which in turn prevents vasoconstriction caused by angiotensin II. NÚMERO DE CAS 107133-36-8

2',4',6'-Trihydroxy-4-nitrodihydrochalconesc-216314 NÚMERO DE CAS 82628-82-8

2',5'-Dideoxyadenosine 3'-monophosphatesc-214084A non-cell-permeable, potent inhibitor of adenylyl cyclase. It is a precursor to 2',5'-Dideoxyadenosine 3'-triphosphate). IC50 = 460 nM in detergent-dispersed rat brain preparation. NÚMERO DE CAS 121878-11-3

TAK 165sc-361372TAK 165 is a potent EGFR and p34cdc2 inhibitor that exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines. NÚMERO DE CAS 366017-09-6

(2S)-(+)-Amino-5-iodoacetamidopentanoic acidsc-202409An irreversible inhibitor of ornithine decarboxylase and arginase. NÚMERO DE CAS 35748-65-3

Quinapril Hydrochloridesc-205829Quinapril hydrochloride is a firmly established angiotensin-converting enzyme (ACE) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin 2 NÚMERO DE CAS 82586-55-8

3-(N-Hydroxyamino)propyl Phosphonatesc-209484 NÚMERO DE CAS 66508-11-0

3-Nitropropionic acidsc-214148A potent, irreversible inhibitor of mitochondrial complex II enzyme, which causes dysfunction and oxidative stress in mitochondria. NÚMERO DE CAS 504-88-1

(R)-Lisinopril Sodium Saltsc-212648(R)-Lisinopril Sodium Salt is the R,S,S-Isomer of Lisinopril. Lisinopril is a potent inhibitor of angiotensin-converting enzyme (ACE). This compound prevents the conversion of angiotensin I to angiotensin II, which acts as a potent vasoconstrictor and also signals the release of aldosterone, which modulates sodium absorption. NÚMERO DE CAS 85955-59-5

3-O-Methyl-N-acetyl-D-glucosaminesc-202886An analog of N-acetyl-D-glucosamine shown to inhibit N-acetylglucosamine kinase and N-acetylmannosamine kinase, without inhibiting glucokinase - potentially useful for accurate assay of glucokinase activity in pancreatic islets and liver tissues. NÚMERO DE CAS 94825-74-8

2
3-Phenylpropyl isothiocyanatesc-204620Synthetic phenyl isothiocyanate that has been found to induce Phase II detoxifying enzymes. Also inhibits chemically induced carcinogenesis. NÚMERO DE CAS 2627-27-2

Ramiprilsc-205833An inhibitor of the angiotensin- converting enzyme (ACE) that is reported to quickly hydrolyze into the active metabolite Ramiprilat. NÚMERO DE CAS 87333-19-5

3,4-Dihydroxyphenyl Ethanolsc-202887Inhibits 5-lipoxygenase and 12-lipoxygenase. Scavenges reactive oxygen species and protects against oxidative damage. Increases cytosolic Ca2+ levels. NÚMERO DE CAS 10597-60-1

1
3,7-Dimethyl-8-(p-sulfonamidophenyl)xanthinesc-209733A weak water soluble A2 -adenosine receptor antagonist. NÚMERO DE CAS 149981-21-5

3,7-Dimethyl-8-p-sulfophenylxanthinesc-209734A weak water soluble A2 -adenosine receptor antagonist. NÚMERO DE CAS 149981-20-4

3'-Deoxy-3'-fluorothymidine-5'-monophosphate Disodium Saltsc-216619A fluoronated analog of thymidine-5'-O-monophosphate. A substrate of Mycobacterium tuberculosis thymidylate kinase with a Km of 30 μM.

3',4',5',5,7-Pentamethoxyflavanonesc-216630 NÚMERO DE CAS 479672-30-5

(3R,5S)-Fluvastatin Sodium Saltsc-206732An anti-lipemic synthetic HMG-CoA reductase inhibitor that contains residual sodium chloride which is quantified on the certificate of analysis. NÚMERO DE CAS 94061-80-0

(3S,5R) Fluvastatin Sodium Saltsc-206738Antilipemic. A synthetic HMG-CoA reductase inhibitor. NÚMERO DE CAS 155229-76-8

(3S,6R)-Lateritinsc-364092 NÚMERO DE CAS 65454-13-9

3α-Mannobiosesc-216644Postulated to be the major antigenic determinant of yeast in cell walls. An inhibitor of fimbrial lectins from enterobacteria. NÚMERO DE CAS 23745-85-9

4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acidsc-214226This compound inhibits collagenase. NÚMERO DE CAS 124168-73-6

4-Chloro-1H-pyrazolo[3,4-d]pyrimidinesc-216799This has a SK channel blocker effect. NÚMERO DE CAS 5399-92-8

4-Chloro-DL-phenylalanine methyl ester hydrochloridesc-238813Tryptophan hydroxylase inhibitor. This can cross the blood brain barrier better than p-chlorophenylalanine. NÚMERO DE CAS 14173-40-1

4-Chlorophenylguanidine hydrochloridesc-203474Potent and specific inhibitor of urokinase. NÚMERO DE CAS 14279-91-5

Temocapril Hydrochloridesc-204908An ACE inhibitor (angiotensin converting enzyme). Pro-drug that is converted in vivo to treat hypertension. NÚMERO DE CAS 110221-44-8

4-Formylpiperidine-1-carboxylic Acid tert-Butyl Estersc-216846Intermediate for polycyclic indazole derivatives which are ERK inhibitors. NÚMERO DE CAS 137076-22-3

4-Methylpyrazole hydrochloridesc-214254Alcohol dehydrogenase inhibitor. Antidote in methanol and ethylene glycol poisoning. NÚMERO DE CAS 56010-88-9

4-Oxatetradecanoic acidsc-202422Analog of myristate with same chain length but a polar oxygen atom incorporated in place of a methylene group, resulting in reduced hydrophobicity. Inhibits HIV replication. NÚMERO DE CAS 7420-16-8

(4-Sulfamoylphenyl)hydrazine Hydrochloridesc-217009 NÚMERO DE CAS 17852-52-7

4,5,6,7-Tetrabromobenzimidazolesc-217031A selective ATP-competitive inhibitor of protein kinase CK2 from such divergent sources as yeast, rat liver, Neurospora erassa and Candida tropicalis, with Ki values in the range of 0.5-1uM. It is virtually inactive against PKA, PKC, and a very weak NÚMERO DE CAS 577779-57-8

4'-Demethylepipodophyllotoxinsc-206950A potent inhibitor of microtubule assembly. NÚMERO DE CAS 6559-91-7

4'-Deoxyphlorizinsc-206951Inhibitor of the glucose transport system. NÚMERO DE CAS 4319-68-0

4'-Hydroxy Atomoxetinesc-217050A metabolite of Tomoxetine (Atomoxetine, LY 139603). NÚMERO DE CAS 435293-66-6

4'-Hydroxy Atomoxetine β-D-Glucuronidesc-210189A metabolite of Tomoxetine (Atomoxetine, LY 139603). NÚMERO DE CAS 540729-08-6

4'-Hydroxy Atomoxetine β-D-Glucuronide-d3sc-217051A labeled metabolite of Tomoxetine.

4'-Hydroxy Atomoxetine-d3sc-217052A labeled metabolite of Tomoxetine.

4E1RCatsc-3610854E1RCat is an inhibitor of protein translation that has been shown to prevent eIF4E:eIF4G and eIF4E:4E-BP1 interaction. This compound blocks assembly of the eIF4F complex and inhibits cap-dependent translation. NÚMERO DE CAS 328998-25-0

5-Cyanoindolesc-217174Inhibitor of enzyme. NÚMERO DE CAS 15861-24-2

5-epi-Isofagominesc-207026Strongly and selectively inhibits β-Glucosidase. NÚMERO DE CAS 202979-51-9

5-Ethynyl-1-(β-D-ribofuranosyl)-imidazo-4-carbonitrilesc-217178 NÚMERO DE CAS 126004-13-5

5-Iodo-1-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-imidazo-4-carbonitrilesc-217209

5-Iodonaphthalene-1-sulfonylchloridesc-210352A synthetic intermediate. NÚMERO DE CAS 110448-35-6

6-Aminonicotinamidesc-278446An inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase. NÚMERO DE CAS 329-89-5

5HPP-33sc-2143495HPP-33 exhibits antiproliferative, antimitotic, and microtubule-stabilizing activities. It acts as a microtubule formation inhibitor. NÚMERO DE CAS 105624-86-0

6-ECDCAsc-280538A novel derivative of cholic acid which acts as a potent and selective FXR agonist (EC50= 99nM) displaying anticholeretic activity in an in vivo rat model of cholestasis. It not only inhibits vascular smooth muscle cell inflammation and migration but also promotes adipocyte differentiation and regulates adipose cell function in vivo. NÚMERO DE CAS 459789-99-2

6-Methoxypurinesc-291383Phosphoribosyltransferase inhibitor. NÚMERO DE CAS 1074-89-1

6-Nitroindazolesc-217371Anticonvulsant. NÚMERO DE CAS 7597-18-4

6,7-Dihydroxyswainsoninesc-217387This is a Swainsonine analogue which inhibits a-mannosidase with 20-to 100-fold less activity. NÚMERO DE CAS 144367-16-8

6,7-Dimethyltetrahydropterin (hydrochloride)sc-205161A noncompetitive inhibitor of GTP cyclohydrolase I exhibiting an IC50 of 76-112 µM. NÚMERO DE CAS 167423-51-0

6'-Carboxy Simvastatinsc-207136A HMG-COA reductase inhibitor. Useful as anticholesteramic. NÚMERO DE CAS 114883-30-6

(-)-(6S)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazolesc-217401A (S)-Pramipexole intermediate. Acts as a dopamine autoreceptor agonist. NÚMERO DE CAS 106092-09-5

6-Bromoandrostenedionesc-207138Androstenedione analog, an aromatase inhibitor NÚMERO DE CAS 38632-00-7

7-(Trifluoromethyl)1H-indole-2,3-dionesc-217411An indole derivative. Acts as an inhibitor of COX-1, COX-2, and Œ≤-catenin. Useful in the treatment of diseases such as lung cancer, diabetes and Alzheimerís disease. NÚMERO DE CAS 391-12-8

7-Epi 10-Desacetyl Paclitaxelsc-207169Paclitaxel impurity and Paclitaxel related compound B. The compound has been isolated from Taxus yunnanensis and shown to have potential growth inhibitory activities against human cancer cells. NÚMERO DE CAS 78454-17-8

7-O-[2-(1,3-Dioxanyl)ethyl]daidzeinsc-217465A potent inhibitor of aldehyde dehydrogenase isozyme (ALDH2) and MOA.

7-O-Ethyldaidzeinsc-207181A potent inhibitor of aldehyde dehydrogenase isozyme (ALDH2) and MOA, NÚMERO DE CAS 146698-96-6

7-O-w-Bromopropyldaidzeinsc-207182Potent MOA and aldehyde dehydrogenase isozyme (ALDH2) inhibitor. NÚMERO DE CAS 309252-38-8

9-Cyclopentyladenine monomethanesulfonatesc-214435A stable, cell-permeable, non-competitive adenylyl cyclase inhibitor that targets the P-site domain. In detergent-dispersed rat brain preparation, IC50 = 100 µM NÚMERO DE CAS 189639-09-6

A 205804sc-203484A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). NÚMERO DE CAS 251992-66-2

10-DEBC hydrochloridesc-203459Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells. NÚMERO DE CAS 201788-90-1

3
10Z-Hymenialdisinesc-360987This product is a novel alkaloid isolated from Axinella damicornis. It is known to act as an ATP-competitive kinase inhibitor. It exhibits inhibitory activity against cyclin-dependent kinases, CK1 and GSK-3β. It has also been shown to block the phosphorylation of tau at in vivo sites that are hyperphosphorylated by CDK5/p352 and GSK. In U937 cells and rhematoid synovial fibroblasts, it is found to inhibit IL-8 production that is mediated by κB. NÚMERO DE CAS 82005-12-7

A 286982sc-362705A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 = 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion, respectively). NÚMERO DE CAS 280749-17-9

13-cis-Retinoic acidsc-205568A vitamin A analog that inhibits cell proliferation and induces cell differentiation. NÚMERO DE CAS 4759-48-2

7
A 839977sc-362707A 839977 is a potent P2X7 antagonist that blocks BzATP-evoked calcium influx at P2X7 receptors. NÚMERO DE CAS 870061-27-1

A 922500sc-203793Diacyl glycerolacyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. NÚMERO DE CAS 959122-11-3

Abiraterone Acetatesc-207240Abiraterone acetate has seen to be a novel steroidal inhibitor of C17,20 lyase. It has been observed to decrease the DHEA, androstenedione and testosterone. NÚMERO DE CAS 154229-18-2

AC 45594sc-203798Selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50-100 nM). Displays no activity at estrogen, LRH-1, ROR, ERR or Nurr receptors. Inhibits SFRE-mediated transcription. NÚMERO DE CAS 13037-86-0

Acenaphthenequinonesc-239180A quinoid polycyclic aromatic hydrocarbon, which acts as a redox-active compound. This compound is used to study ROS induced damage to lung tissue. NÚMERO DE CAS 82-86-0

Acetazolamidesc-214461Acetazolamide is an inhibitor of carbonic anhydrase. NÚMERO DE CAS 59-66-5

Acetildenafilsc-207250A designer drug which acts as a phosphodiesterase inhibitor. Also a structural analog of Sidenafil (Viagra). NÚMERO DE CAS 831217-01-7

Acetohydroxamic Acidsc-207251A inhibitor of urease. NÚMERO DE CAS 546-88-3

AG 1433 HClsc-221220A specific and potent inhibitor of PDGF-β receptor kinase (IC550 = 5.0 µM) and of KDR/Flk-1/VEGF Receptor 2 (IC50 = 9.3 µM). Acts also as angiogenesis inhibitor.

Agistatine Bsc-202918A tricyclic analog of agistatine A, which has been described as an inhibitor of cholesterol biosynthesis. NÚMERO DE CAS 144096-46-8

Agistatine Dsc-202919Analog of agistatine A, which has been described as an inhibitor of cholesterol biosynthesis. NÚMERO DE CAS 144096-47-9

AICAR-Tri-O-Acetatesc-217591 NÚMERO DE CAS 23274-21-7

Aloeresin Asc-202922An inhibitor of α-glucosidase that can be converted to p-couramic and aloesin. NÚMERO DE CAS 74545-79-2

ALX 5407 hydrochloridesc-361102ALX 5407 hydrochloride shown to act as a selective non-transportable inhibitor of the glycine transporter GlyT1. NÚMERO DE CAS 571147-18-7

AMD3100 octahydrochloride hydratesc-252367A selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. NÚMERO DE CAS 155148-31-5 (anhydrous)

1
AMI-1 sc-364098

Aminopterinsc-202461Folic acid antagonist. Potent dihydrofolate reductase inhibitor. NÚMERO DE CAS 54-62-6

Androst-4-ene-3,6,17-trionesc-207292An aromatase inhibitor. NÚMERO DE CAS 2243-06-3

Anisindionesc-291902 NÚMERO DE CAS 117-37-3

ARL 67156 trisodium saltsc-203521ARL 67156 is a newly synthesized analogue of ATP which functions as a selective ecto-ATPase inhibitor. In addition, studies suggest that ARL 67156 trisodium salt also acts as a weak antagonist for the purinoceptors P2X and P2T and as an agonist for P2u. NÚMERO DE CAS 160928-38-1

AS 101sc-203825Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1a, IL-2 and TNFa release NÚMERO DE CAS 106566-58-9

(+)-AS 115sc-205216A potent and selective inactivator of KIAA1363, displaying an IC50n value of 150 nM when tested as a racemic mixture in the SK0V-3 cell line. The activities of the individual enantiomers have not been determined. NÚMERO DE CAS 926657-43-4

(−)-AS 115sc-221270KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase which is upregulated in aggressive cancers from an array of tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SK0V-3.2 Treatment of SKOV-3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and (−)-AS 115, has not been determined. NÚMERO DE CAS 926657-43-4

Atomoxetine-d3, Hydrochloridesc-217670A labeled analogue of Tomoxetine.

Aurintricarboxylic acid ammonium saltsc-210849Aluminum reagent that readily polymerizes in solution (aq), producing a free radical that inhibits protein-nucleic acid interactions. Inhibits ribonuclease and topoisomerase Il2 through the prevention of enzyme-nucleic acid binding. Stimulates tyrosine phosphorylation and inhibits apoptosis in many cell types. NÚMERO DE CAS 569-58-4

AX 048sc-358797A PLA2 and PGE2 inhibitor.Contains a specific affinity for group IVA cPLA2 which moderates antihyperalgesia effects. NÚMERO DE CAS 873079-69-7

Azamulinsc-207310A highly selective human CYP3A4 inhibitor and a mutilin derivative. NÚMERO DE CAS 76530-44-4

B-3530sc-291922Inhibits cathepsins B, L, and S with similar kinetics. The diiodinated compound reacts irreversibly with cathepsins B and L, but not with cathepsin S and is able to penetrate cells and react with active enzymes within the cells. Often abbreviated DMK. Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

AT-56sc-344899A selective, competitive, and highly bioavailable inhibitor of L-PGDS with a Ki value of 75 µM. NÚMERO DE CAS 162640-98-4

Bambuterol Hydrochloridesc-205598A bronchodilator. It inhibits plasma cholinesterase during metabolism prolongs suxamethonium-induced neuromuscular blockade. NÚMERO DE CAS 81732-46-9

Bax channel blockersc-203524Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity. NÚMERO DE CAS 335165-68-9

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BAY 73-6691sc-252407Characterized in vitro as the first potent and selective inhibitor of phosphodiesterase 9 (PDE9). NÚMERO DE CAS 794568-92-6

BAY 61-3606 hydrochloride hydratesc-360240

BAY-60-7550sc-205219Antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling. NÚMERO DE CAS 439083-90-6

Benzamidine HCl hydratesc-207323A reversible inhibitor of serine proteases, trypsin and trypsin-like enzymes. It has also been shown to be a strong inhibitor of plasma and thrombin. NÚMERO DE CAS 206752-36-5

Benzisoxazole Hsp90 Inhibidorsc-223790Binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site; inhibits the proliferation of several cancer cell lines. NÚMERO DE CAS 1012788-65-6

Benzyl isothiocyanatesc-204641An inhibitor of methylazoxymethanol acetate-induced intestinal carcinogenesis. NÚMERO DE CAS 622-78-6

Benzyl thiocyanatesc-204643Effective against methylazoxymethanol acetate-induced intestinal carcinogenesis. NÚMERO DE CAS 3012-37-1

Berberinesc-204645Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Also inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. NÚMERO DE CAS 633-65-8

BIBB 515sc-205221An important enzyme in the biosynthesis of animal, fungal and plant sterols; a selective and potent inhibitor of 2,3-Oxidosqualene cyclase (OSC) in vivo. NÚMERO DE CAS 156635-05-1

BIBR 1532sc-203843BIBR 1532 is a compound suggested to act as a selective and specific telomerase inhibitor. BIBR 1532 is shown to inhibit hTERT and cell proliferation. NÚMERO DE CAS 321674-73-1

Bioallethrinsc-202501Though a type I pyrethroid, its effects on calcineurin (PP2B) resembles those of type II pyrethrins. Unlike most type I pyrethrins, which are very weak, bioallethrin is a potent calcineurin inhibitor. NÚMERO DE CAS 22431-63-6

Bis[(4-chlorophenyl)thiomethylene]biphosphonic Acid, Tetraisopropyl Estersc-207374An intermediate in the synthesis of Tilduronic Acid, a biphosphonate bone resorption inhibitor. NÚMERO DE CAS 887353-24-4

Bistheonellide Asc-202081A dimeric marine toxin that can inhibit actin polymerization and cell cycle progression in the G1 phase. NÚMERO DE CAS 105304-96-9

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(±)-Blebbistatinsc-203532A selective inhibitor of nonmuscle myosin II ATPase and several striated muscle myosins, while reversibly blocking cell blebbing and disrupting cytokinesis via ubiquitin-mediated proteolysis. NÚMERO DE CAS 674289-55-5

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BMS 453 hydratesc-311294BMS 453 is a synthetic retinoid that is shown to be a retinoic acid receptor antagonist. BMS 453 is noted to cause a cell cycle arrest at G1. Also shown to induce Rb hypophosphorylation. NÚMERO DE CAS 166977-43-1

Bortezomibsc-217785A selective and robust 26S proteasome inhibitor, that is a boronic acid dipeptide derivative. NÚMERO DE CAS 179324-69-7

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Bourgeonalsc-210959A potent agonist at hOR17-4 (a human testicular olfactory receptor) that acts as a strong chemoattractant in sperm behavioral assays. NÚMERO DE CAS 18127-01-0

Brassininsc-202978Effective inhibitor of stage two skin carcinogenesis. Inducer of Phase II enzymes. Inhibitor of chemically induced carcinogenesis. NÚMERO DE CAS 105748-59-2

Bufotalinsc-202509Less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor. NÚMERO DE CAS 471-95-4

BX 513 hydrochloridesc-203861Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). A full inverse agonist at US28, a HCMV-encoded chemokine receptor. NÚMERO DE CAS 193542-65-3

β-cyano-L-Alaninesc-205546A reversible inhibitor of the H2S-synthesizing enzyme cystathionine γ lyase. NÚMERO DE CAS 6232-19-5

C 021 dihydrochloridesc-293973A potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively) NÚMERO DE CAS 864289-85-0

Carbimazolesc-205620An effective thyroid inhibitor NÚMERO DE CAS 22232-54-8

Carbonyl Cyanide m-Chlorophenylhydrazonesc-202984Reported to be a protonophore, and an inhibitor of ER-Goligi protein transport. Also shown to bind Cytochrome C oxidase with a high affinity. NÚMERO DE CAS 555-60-2

Carboxyatractyloside potassium saltsc-214665A highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carriers. For example, adenine nucleotide translocase (ANT) causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and eventually apoptosis. NÚMERO DE CAS 35988-42-2 (non-salt)

CAY10581sc-223871The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in cells and in vitro, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM). It is a more potent inhibitor of IDO than 1-methyl-d-tryptophan (1MT) or annulin B. CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours. NÚMERO DE CAS 1018340-07-2

CAY10594sc-223874A potent PLD2 inhibitor, both in vitro and in cells; strongly inhibits the invasive migration of breast cancer cells in transwell assays. NÚMERO DE CAS 1130067-34-3

CAY10626sc-358741Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR. Aberrent PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3Kα/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases.In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. When administered at 25-50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3Kα and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed. NÚMERO DE CAS 1202884-94-3

CCG 2046sc-204676CCG 2046 is noted to be and inhibitor of the regulator of G-protein signaling 4 (RGS4). NÚMERO DE CAS 13017-69-1

CCG-1423sc-205241CCG-1423 is a specific inhibitor of Rho pathway-mediated signalling and activation of serum response factor (SRF) transcription. NÚMERO DE CAS 285986-88-1

CCT 018159sc-202526CCT 018159 is a cell-permeable pyrazoloresorcinol compound that inhibits Hsp90 ATPase activity by targeting the enzyme's N-terminal ATP binding site. NÚMERO DE CAS 171009-07-7

Cerivastatin, Sodium Saltsc-207418This compound is a competitive inhibitor of HMG-CoA reductase. NÚMERO DE CAS 143201-11-0

CFM 1571 hydrochloridesc-203540Soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM). Does not activate adenylyl cyclase, shows no significant inhibition of phosphodiesterases and displays minimal inhibition of iNOS (25%) and nNOS (17%). Inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM). NÚMERO DE CAS 268725-86-6

cFMS Receptor Inhibidor IIsc-221415A cell-permeable anilinoquinoline compound that acts as a strong, active site-targeting inhibitor of MCSF receptor/cFMS. This inhibitor is much more selective against cFMS-independent growth of NSO cells than cFMS Receptor Inhibitor III. They are both equally potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells.

cFMS Receptor Inhibidor IIIsc-221416A cell-permeable anilinoquinoline compound that acts as a strong, active site-targeting inhibitor of MCSF receptor/cFMS. This compound is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells. NÚMERO DE CAS 959861-21-3

CGS 35066sc-203546Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH). NÚMERO DE CAS 261619-50-5

Chlorothiazidesc-202536Chlorothiazide is a carbonic anhydrase inhibitor that is slightly less potent than Acetazolamide (sc-214461). Chlorothiazide has been shown to block renal reabsorption of sodium and chloride ions. NÚMERO DE CAS 58-94-6

Cicaprostsc-358799An analog of PGI2 which causes IP activation. Activation of IP is associated with phosphorylation of transcription factor cAMP response element binding protein. NÚMERO DE CAS 94079-80-8

Ciclesonidesc-207432A glucocorticoid microemulsion nasal preparation that acts as an allergy inhibitor and treats rhinitis NÚMERO DE CAS 126544-47-6

Cinobufaginsc-202542Specific Na+/K+-ATPase inhibitor. About as active as ouabain NÚMERO DE CAS 470-37-1

Cinobufotalinsc-202101Specific Na+/K+-ATPase inhibitor. Less active than ouabain. NÚMERO DE CAS 1108-68-5

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cis-4-Hydroxy-L-prolinesc-311305Proline antagonist in collagen synthesis. NÚMERO DE CAS 618-27-9

Clavulanic Acid Potassium Saltsc-207446A β-Lactamase inhibitor usually added to amoxicillin to increase its effectiveness. NÚMERO DE CAS 61177-45-5

Collagenase Inhibidor Isc-221432Collagenase Inhibitor I is a potent and specific inhibitor of vertebrate MMP (collagenases) with values in the micromolar range. NÚMERO DE CAS 123984-15-6

Combrestatin A4sc-204697A potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. NÚMERO DE CAS 117048-59-6

Conduritol Asc-211126 NÚMERO DE CAS 526-87-4

Conduritol Dsc-211128 NÚMERO DE CAS 4782-75-6

Coumestrolsc-205638A plant estrogen and highly potent inhibitor of 17-β-hydroxysteroid oxidoreductase. NÚMERO DE CAS 479-13-0

CP 100356 hydrochloridesc-361154Has been reported to be a high affinity multi-drug resistance protein (Mdr-1/P-gp) inhibitor. NÚMERO DE CAS 142716-85-6

CP 316 819sc-207456Glycogen phosphorylase inhibitor and potential treatment for glycemic control in diabetes, type 2. NÚMERO DE CAS 186392-43-8

Cupferronsc-214782A water soluble free radical polymerization inhibitor. NÚMERO DE CAS 135-20-6

CV-6209sc-207461A competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation and PAF induced hypotension and lethality. NÚMERO DE CAS 100488-87-7

Cyclic Pifithrin-α hydrobromidesc-361164Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α - a small molecule inhibitor of p53. NÚMERO DE CAS 511296-88-1

Cyclosporin Hsc-203013An immunologically inactive cyclosporine H that is shown to be a potent inhibitor of phorbol ester. NÚMERO DE CAS 83602-39-5

Cyclothiazidesc-202560Cyclothiazide potently inhibits the desensitization of AMPA receptors. NÚMERO DE CAS 2259-96-3

D-Eritadeninesc-207632A potent inhibitor of S-adenosyl-L-homocysteine hydrolase. It is a hypocholesterolemic that is isolated from shiitake mushrooms and affects phospholipid and linoleicacid metabolisms, decreasing total cholesterol levels in plasma. NÚMERO DE CAS 23918-98-1

D-erythro-2-Tetradecanoylamino-1-phenyl-1-propanolsc-280655 NÚMERO DE CAS 143492-39-1

D-erythro-Dihydro-D-sphingosine-1-phosphatesc-211174Used as a negative control for C2 Ceramide. NÚMERO DE CAS 108126-32-5

D-erythro-N,N-Dimethylsphingosinesc-211175A general modulator of protein kinases. NÚMERO DE CAS 119567-63-4

D-Limonenesc-205283Monoterpene found to prevent mammary cancer by inducing hepatic glutathione-S- transferase and uridine diphosphoglucuronosyl transferase. Isoprenylation inhibitor of small G-proteins. NÚMERO DE CAS 5989-27-5

D,L-Benzylsuccinic Acidsc-207490Effective carboxypeptidase inhibitor. NÚMERO DE CAS 36092-42-9

D,L-Venlafaxinesc-207501An isomer of Venlafaxine, the reuptake inhibitor of neuroamines such as serotonin and norepinephrine. NÚMERO DE CAS 93413-69-5

Dabigatran etexilatesc-351724Dabigatran etexilate is the prodrug of the active moiety dabigatran. Dabigatran etexilate has recently been in clinical trials for use as an anticoagulant drug. It has been shown to have slight, but significant drug-drug interactions when used in combination with strong P-glycoprotein inducers or inhibitors such as amiodarone (sc-291891) or rifampicin (sc-200910). It has also been associated with lower rates of stroke and systemic embolism than warfarin (sc-205888), a comparable anticoagulant. NÚMERO DE CAS 211915-06-9

Daidzinsc-202123A kudzu isoflavone. Demonstrates chemopreventive activities by inhibiting the bioactivation of carcinogenic arylamines. Daidzin is also an inhibitor of human mitochondrial aldehye dehydrogenase. NÚMERO DE CAS 552-66-9

Daltrobansc-214835A selective thromboxane A2 receptor antagonist which exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity. NÚMERO DE CAS 79094-20-5

Danazolsc-203021A synthetic gonadotropin inhibitor which has a preventive effect on estrogen-related endometrial carcinogenesis in mice. NÚMERO DE CAS 17230-88-5

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Daunorubicinol (mixture of diastereomers)sc-218089A Daunorubicin metabolite. NÚMERO DE CAS 28008-55-1

Decarestrictine Dsc-202571A 10-membered lactone which potently inhibits cholesterol biosynthesis and shows hypolipidemic activity. NÚMERO DE CAS 127393-89-9

Dechlorane 603sc-211216A chlorinated polycyclic compound which is an antioxidant having prolonged thermal stability NÚMERO DE CAS 13560-92-4

Dechlorane Asc-363275 NÚMERO DE CAS 13560-89-9

Demecolceinesc-218111An antimitotic agent that disrupts microtubles preventing tubulin polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates JNK/SAPK signaling. NÚMERO DE CAS 518-11-6

Demecolcine Hydrogen Bromide Saltsc-218112An antimitotic agent that disrupts microtubles preventing tubulin polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates JNK/SAPK signaling.

Deoxy Blebbistatinsc-218116A Blebbistatin derivative, a compound that blocks myosin II-dependent cell processes. NÚMERO DE CAS 856925-72-9

Desmethyl Atomoxetine Hydrochloridesc-207537A metabolite of Tomoxetine (Atomoxetine, LY 139603). NÚMERO DE CAS 881995-46-6

Desmethyl Atomoxetine-d7 Hydrochloride Saltsc-218148A labeled derivative of Tomoxetine.

Diallyl sulfidesc-204718A modulator of drug metabolizing enzyme P450 system and inducer of the phase II detoxifying enzyme GST. Inhibitor of chemical-induced carcinogenesis in many tissues. NÚMERO DE CAS 592-88-1

Diethylumbelliferyl phosphatesc-211328A potent, selective cholesterol esterase inhibitor which blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC50= 11.6 µM. NÚMERO DE CAS 897-83-6

Dipeptidylpeptidase II Inhibidorsc-221546Aminoacylpiperidine compound that acts as a strong and very specific inhibitor of dipeptidylpeptidase II. Displays >7,700-fold selectivity for DPP II over DPP IV from human seminal fluid.

Dipeptidylpeptidase IV Inhibidor IIsc-221547Dipeptidylpeptidase IV Inhibitor II is a new acylating inhibitor for the proline-specific peptidases dipeptidylpeptidase II and IV (CD26). NÚMERO DE CAS 1258008-19-3

Disodium Cycloheptylaminomethylene diphosphonatesc-204731While used in the treatment of bone disorders, it inhibits squalene synthase and cholestrol biosynthesis. NÚMERO DE CAS 138330-18-4

DL-2-Mercaptomethyl-3-guanidinoethylthiopropanoic Acidsc-311322A potent and reversible inhibitor of human plasma carboxypeptidase N. Reported to inhibit hydrolysis of bradykinin. NÚMERO DE CAS 77102-28-4

DL-Propargylglycine (hydrochloride)sc-221558An irreversible inhibitor of cystathionine-γ-lyase (CSE), which is a H2S synthesizing enzyme. This compound also inhibits methionine biosynthesis, causes growth inhibition and morphological changes.

DMFO Hydrochloridesc-203563A specific irreversible inhibitor of ornithine decarboxylase, which shows antiapoptotic, antiparasitic, and antiangiogenic activity. NÚMERO DE CAS 70052-12-9

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Docetaxel Trihydratesc-207594This compound acts as an antineoplastic, as well as an antimitotic agent that promotes the assembly of microtublules which inhibits their depolymerization to free tubulin. NÚMERO DE CAS 148408-66-6

Dutasteridesc-207600Dutasteride is a 5-alpha-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-alpha reductase to a similar extent. NÚMERO DE CAS 164656-23-9

Dynasore monohydratesc-214953A cell-permeable, reversible noncompetitive dynamin 1 and 2 GTPase activity inhibitor, where it also inhibits mitochondrial Drp1. Dynasore blocks dynamin-dependent endocytosis and scission of endocytic vesicles. it is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections. NÚMERO DE CAS 304448-55-3 (anhydrous)

Elacridarsc-207613A prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport. NÚMERO DE CAS 143664-11-3

Elacridar-d4sc-218297A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport. NÚMERO DE CAS 143664-11-3 (unlabeled)

Elasninsc-364110 NÚMERO DE CAS 68112-21-0

Enalapril Maleatesc-205666An angiotensin-converting enzyme inhibitor. Actively interferes with the renin-angiotensin- aldosterone system. NÚMERO DE CAS 76095-16-4

ent Atomoxetine-d3, Hydrochloridesc-218309A labeled enantiomer of Tomoxetine.

ent S-(+)-Atomoxetine Hydrochloridesc-211408An enantiomer of Atomoxetine (Tomoxetine, LY 139603) which is less effective than Tomoxetine as a competitive and specific inhibitor of norepinephrine. NÚMERO DE CAS 82857-39-4

EO 1428sc-203942Selective inhibitor of p38α and p38β2. Displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis. NÚMERO DE CAS 321351-00-2

Epostanesc-207627A 3β-Hydroxysteroid dehydrogenase inhibitor and a derivative of trilostane. Interceptive. NÚMERO DE CAS 80471-63-2

ErbB2 Inhibidor IIsc-221592Cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2. Reduces the phosphorylation of erbB2 in MDA-MB-453 cells, but not that of the over-expressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Has been shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM. NÚMERO DE CAS 928207-02-7

Esomeprazole Magnesiumsc-207635Omeprazole S-form and gastric proton pump inhibitor. NÚMERO DE CAS 217087-09-7

Estrone 3-O-Sulfamatesc-207641A potent inhibitor of estrone sulfatase. This compound inhibits estrone sulfatase >99% at 0.1μM in intact MCF-7 cells, IC50=65pM. NÚMERO DE CAS 148672-09-7

Etidronate Disodiumsc-205687Etidronate Disodium is a bisphosphonate bone resorption inhibitor Phosphonate ligands demonstrate a very high affinity for alkali metal ions and form crystals with some difficulty. Organophosphonate chelating compounds are able to prevent precipitation of calcium salts at stoichiometric concentrations which is applicable in corrosion inhibition, water treatment and scale inhibition. NÚMERO DE CAS 7414-83-7

Etravirinesc-207674Novel HIV reverse transcriptase inhibitor useful in treatment of HIV infection. NÚMERO DE CAS 269055-15-4

Exo 1sc-215010A reversible inhibitor of exocytosis Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator. NÚMERO DE CAS 75541-83-2

Ezetimibesc-205690A cholesterol transport inhibitor that affects NPC1L1 and prevents its incorporation into membrane clathrin-coated vesicles. NÚMERO DE CAS 163222-33-1

Farnesyl Thiosalicylic Acid Amidesc-223986Association of Ras protein to the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) inhibits Ras-mediated signaling by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of U87 and Panc-1 tumor cells with IC50 values of 10 and 20 µM, respectively, a relatively higher potency compared to that of FTS (IC50s = 50 and 35 µM, respectively) (2). Treatment of nude mice bearing either Panc-1 or U87 glioblastoma tumors with 100 mg/kg FTS-amide twice daily for four days inhibits tumor growth by at least 50% of controls. NÚMERO DE CAS 1092521-74-8

Fasentinsc-215012A novel glucose uptake (GluT1) inhibitor. Evasion of death receptor ligand-induced apoptosis is an important contributor to cancer development and progression. Therefore, compounds that restore sensitivity to death receptor stimuli would be important tools to better understand this biological pathway and provide potential leads for therapeutic adjuncts. Sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters gene expression associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1. It highlights a new mechanism to sensitize cells to death ligands. Dipyridamole (sc-200717), which is a weak GluT inhibitor which partially inhibits glucose uptake ane sensitize cells to FAS. Two glucose uptake inhibitor, phloretin & cytochalasin B, have been reported to be highly toxic and not sensitize cells to FAS. NÚMERO DE CAS 392721-37-8

FBPase-1 Inhibidorsc-221608A cell-permeable benzoxazolo-sulfonamide compound that inhibits hFBPase-1 enzymatic activity by competing at the AMP allosteric binding site. Has been shown to block glucose production in starved rat hepatoma cells. NÚMERO DE CAS 883973-99-7

Febuxostatsc-207680This compound inhibits xanthine oxidase and xanthine dehydrogenase, where it is used for the treatment of chronic gout and hyperuricemia. NÚMERO DE CAS 144060-53-7

FK-866sc-205325A non-competitive and specific inhibitor of nicotamide phosphrybosyltransferase that mediates NAD+ biosynthesis within cells and causes apoptosis. NÚMERO DE CAS 658084-64-1

FKGK 11sc-223989Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a lysophospholipid and a free fatty acid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-independent cytosolic (iPLA2), and calcium-dependent cytosolic (cPLA2), that have different functions. FKGK 11 is a selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA2 by 50% . In comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only minute inhibition of sPLA2. NÚMERO DE CAS 1071000-98-0

Flurofamidesc-203957A bacterial urease inhibitor with a potency 1000 fold greater than Acetohydroxamic Acid. NÚMERO DE CAS 70788-28-2

Fluvoxaminesc-207697A selective serotonin reuptake inhibitor (SSRI), which is used as an anti-depressant. NÚMERO DE CAS 54739-18-3

Foroxymithinesc-202159A potent chelator of the ferrous ion and specific inhibitor of angiotens.in I converting enzyme at an IC50 of 7μg/ml NÚMERO DE CAS 100157-28-6

Fosinopril sodiumsc-205702An angiotensin-converting enzyme inhibitor shown to protect the organs in sinoaortic-denervated rats. NÚMERO DE CAS 88889-14-9

Furosemidesc-203961Furosemide is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter. Furosemide acts as a non-competitive antagonist at GABAA receptors. NÚMERO DE CAS 54-31-9

Gadolinium (III) chloride hexahydratesc-202617Inhibits macrophages. NÚMERO DE CAS 13450-84-5

Galactostatin Bisulfitesc-218555A β-galactosidase inhibitor. NÚMERO DE CAS 1196465-02-7

Galiellalactonesc-202165A hexaketide metabolite, which selectively inhibits IL-6 induced SEAP expression by blocking the binding of activated Stat3 dimers to DNA. NÚMERO DE CAS 133613-71-5

Gamma-Secretase Inhibidorsc-221656Reversible peptidomimetic inhibitor of Alzheimer's Gamma-Secretase activity.

Geduninsc-203967Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity. NÚMERO DE CAS 2753-30-2

Gemfibrozil 1-O-β-D-Glucuronide Allyl Estersc-280722Gemfibrozil glucuronide derivative.

Glutaryl-leu-OHsc-285863Potent and highly specific enkephalinase inhibitor. NÚMERO DE CAS 209127-97-9

Granisetronsc-203983Used to successfully treat post operative nausea. NÚMERO DE CAS 109889-09-0

GSK 264220Asc-295026An endothelial lipase and a lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively). NÚMERO DE CAS 685506-42-7

GW788388 Hydratesc-363544GW788388 is a potent and selective inhibitor of TGF-&beta type I receptor [activin receptor-like kinase 5 (ALK5)]. NÚMERO DE CAS 452342-67-5 (anhydrous)

GW311616Asc-215120A potent inhibitor of intracellular human neutrophil elastase (HNE, α-1-proteinase). NÚMERO DE CAS 197090-44-1

Hdm2 E3 Ligase Inhibidorsc-221707A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). The inhibition is non-competitive with respect to either the donor or acceptor substrate. Exhibits little effect towards other ubiquitin-using enzymes. NÚMERO DE CAS 414905-09-2

Heat Shock Protein Inhibidor Isc-221709Heat Shock Protein Inhibitor I inhibits HSP 70, HSP 72, and HSP 105. Heat Shock Protein Inhibitor I blocks the development of thermotolerance in a dose-dependent manner. NÚMERO DE CAS 218924-25-5

Hellebrinsc-202645Cardiotonic glycoside with a bufadienolide-steroid structure. Extremely potent inhibitor of Na+/K+-ATPase and blocks efflux of Na+ and reuptake of K+ of this enzyme. NÚMERO DE CAS 13289-18-4

Heptakis(2,3-di-O-methyl-6-O-sulfo)-β-cyclodextrin Heptasodium Saltsc-207730Anthrax lethal toxin inhibitor and β-Cyclodextrin derivative NÚMERO DE CAS 201346-23-8

Hexestrolsc-205713A carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures, while also an inhibitor of lipid peroxidation. NÚMERO DE CAS 84-16-2

HIF-1 Inhibidorsc-221724Cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein. Exhibits no apparent effect on the cellular level of HIF-1α mRNA nor HIF-1. NÚMERO DE CAS 934593-90-5

HQNOsc-202654A high affinity inhibitor of quinone oxidation and Zn(II), also described to inhibit proton channels needed to reduce oxygen and the activity of proton pumps. NÚMERO DE CAS 341-88-8

HSD Inhibidor 23sc-203076Selective, potent and cell permeable small molecule inhibitor of 11-β-hydroxysteroid dehydrogenase NÚMERO DE CAS 868604-75-5

HWY 5069sc-207737An isoquinolinium derivative which inhibits the proliferation of wild-type and all mutants of Schizosaccharomyces pombe. NÚMERO DE CAS 914917-58-1

Hydroxylamine hydrochloridesc-211616A compound used as a catalyst, copolymerization inhibitor, and swelling agent that acts as a potent reducing agent, converting aldehydes and ketones to oximes. Also exhibits acitivity of converting acid chlorides to hydroxamic acids. Displays inhibitive activity as an MAO inhibitor for platelet aggregation. NÚMERO DE CAS 5470-11-1

Ibandronic Acidsc-207749A biphosphonate bone resorption inhibitor. NÚMERO DE CAS 114084-78-5

Ibufenacsc-211624Used as an analgesic and anti-inflammatory. NÚMERO DE CAS 1553-60-2

ICI 192,605sc-361209ICI 192,605 has been shown to be a potent thromboxane A2 receptor antagonist. Studies have reported that this compound competitively inhibits contractile responses to U 46619. NÚMERO DE CAS 117621-64-4

IDFPsc-205348An organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by 10-fold. NÚMERO DE CAS 615250-02-7

IDRA 21sc-202659IDRA 21 is an analog of cyclothiazide. IDRA 21 inhibits AMPA receptor desensitization. NÚMERO DE CAS 22503-72-6

[Ile7]-Angiotensin IIIsc-295174Angiotensin III inhibitor. NÚMERO DE CAS 102029-49-2

Imidapril Hydrochloridesc-207751An inhibitor of angiotensin converting enzyme (ACE). Antihypertensive. NÚMERO DE CAS 89371-37-9

IMS2186sc-211638An anti-proliferative and anti-angiogenic compound. IMS2186 is a novel synthetic compound developed as an anti-CNV drug. The proposed mechanism of action under investigation, is blocking the cell cycle at G2 and inhibiting the production of PGE2/TNF-α. The latter contributing to anti-angiogenic and antiinflammatory effects. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50= 0.1 µM) and cell migration, which plays a role in many biological processes: inflammation, angiogenesis, and scar formation. The physicochemical structure of IMS2186 showed also that the free drug concentration in a physiological media (e.g., vitreous or saline) is 8-10 µM above the IC50 for all these activities (0.1-3.0 µM). Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss. NÚMERO DE CAS 1031206-36-6

INH1sc-295181Inhibitor that binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10-20 μM). NÚMERO DE CAS 313553-47-8

Inotilonesc-207758A potent COX-2 inhibitor. NÚMERO DE CAS 906366-79-8

Isocarboxazidsc-218606Monoamine oxidase inhibitor. Antidepressant. NÚMERO DE CAS 59-63-2

Isodemecolcinesc-280855An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signali NÚMERO DE CAS 4702-33-4

ITX 3sc-295214A selective inhibitor of TrioN RhoGEF activity. Has been shown to inhibit TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro. NÚMERO DE CAS 347323-96-0

IWR-1 sc-252929Act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the β-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). NÚMERO DE CAS 430429-02-0

JZL184sc-224031JZL184 is a strong and selective inhibitor of Monoglyceride Lipase (monoacylglycerol lipase, MAGL). NÚMERO DE CAS 1101854-58-3

KAD-1229 Calcium Hydratesc-207776Inhibitor of ATP-sensitive K+ channel activity in MIN 6 cells. Has also been shown to bind sulfonylurea receptors as well. NÚMERO DE CAS 207844-01-7

Ketorolacsc-279250 NÚMERO DE CAS 74103-06-3

KF 38789sc-203617Selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo. NÚMERO DE CAS 257292-29-8

Ko 143sc-204030Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. NÚMERO DE CAS 461054-93-3

L-4-Fluoro-phenyl-alaninesc-207785Substrate for tyrosine hydroxylase that has been used to study the regulation of that enzyme. Substitution of p-fluorophenylalanine for phenylalanine in the culture medium inhibits mitosis and reversibly arrests HeLa cells in G2. NÚMERO DE CAS 1132-68-9

L-5,5-Dimethylthiazolidine-4-carboxylic Acidsc-207786Found to act on the cell membrane of tumor cells, possiblly causing a reverse transformation to normal cells through restoration of contact inhibition. NÚMERO DE CAS 72778-00-8

L-690,330sc-202685A bisphosphonate inhibitor of inositol monophosphate. Described to dose-dependently increase brain inositol(I)phosphate levels during cholinergic stimulation. NÚMERO DE CAS 142523-38-4

L-Buthionine-(S,R)-Sulfoximinesc-218630Potent and specific inhibitor of α-glutamylcysteine synthetase. NÚMERO DE CAS 83730-53-4

L-Phenylalaninolsc-204786Inhibits ulcer formaiton by the reduction of gastric acid secretion. NÚMERO DE CAS 3182-95-4

Lansoprazolesc-203101H+,K+-ATPase inhibitor that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion. NÚMERO DE CAS 103577-45-3

(-)-Lentiginosinesc-207824A selective and powerful amyloglucosidase inhibitor. NÚMERO DE CAS 125279-72-3

Leuhistinsc-202692Leuhistin is an inhibitor of aminopeptidase N (CD13). NÚMERO DE CAS 129085-76-3

Limoninsc-204793Bitter principle of citrus fruits. Chemically induced carcinogenesis inhibitor and HIV-1 replication inhibitor. Shows antinociceptive effect. Does not possess any inherent antioxidant activity. NÚMERO DE CAS 1180-71-8

Liranaftatesc-207828A squalene epoxidase inhibitor that is used as an antifungal agent. NÚMERO DE CAS 88678-31-3

Lysyl Endopeptidasesc-360250

(+)-Madindoline Asc-202702Madindolines are noncytotoxic indole alkaloids. (+)-Madindoline A (MadA; MDL-A) binds competitively but noncovalently to gp130 inhibiting downstream activation of the JAK/STAT pathway. NÚMERO DE CAS 184877-64-3

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MAZ51sc-202703Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC50=1µM). NÚMERO DE CAS 163655-37-6

MDL 72527sc-295375A polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Has been shown to display anticancer and neuroprotective activity in vivo. NÚMERO DE CAS 93565-01-6

MEDICA 16sc-203131Hypolipidemic and antidiabetic agent. Inhibitor of citrate lyase and acetyl-CoA carboxylase, expected to disinhibit hepatic fatty acid oxidation. NÚMERO DE CAS 87272-20-6

Membrane Traffic Inhibidor, A5sc-353670Membrane Traffic Inhibitor, A5 is a piperazinyl compound that specifically block clathrin adaptor complex AP-1-dependent traffic between endosomes and trans-Golgi network (TGN) in budding yeast.

Metastin, Syntheticsc-221884A KiSS-1 gene product with 54 amino-acid residues and a C-terminally amidated LRF-motif that acts as a metastasis inhibitor by G-protein-coupled receptors (GPCRs). It is reported to inhibit chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro (IC50 = 50 nM) and attenuates pulmonary metastasis of hOT7T175-transfected B16-BL6 melanomas in vivo. This is shown to be a potent and selective agonist of AXOR12 and hOT7T175 (a novel human GPCR). It induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells. It also binds to hOT7T175 with high affinity (Kι = 340 pM, determined by competitive binding analysis).

Methantheline bromidesc-279310 NÚMERO DE CAS 53-46-3

Methyl α-Linolenyl Fluorophosphonatesc-221926An analog of methyl arachidonyl fluorophosphonate (MAFP), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand. The pharmacology of the α-linolenyl analog of MAFP has not been completely investigated.

Methyl γ-Linolenyl Fluorophosphonatesc-221932An analog of methyl arachidonyl fluozophosphonate (MAFP), which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand. The pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.

Mildronatesc-207887A pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium. NÚMERO DE CAS 76144-81-5

MPP dihydrochloridesc-204098MPP dihydrochloride is a selective, high affinity silent antagonist at ERα. NÚMERO DE CAS 289726-02-9

MRN-ATM Pathway Inhibidor, Mirinsc-203144Shown to be a cell permeable compound that prevents MRN-dependent activation of ATM. Also reported to inhibit MRE11 which causes a reduction in the efficiency of nonhomologous end joining. NÚMERO DE CAS 299953-00-7

Mycalolide Bsc-358736A compound shown to inhibit actin polymerization (IC50=10-50 nM), suppress actin-activated myosin Mg2+-ATPase activity and abolish both ADP and collagen-induced platelet aggregation. NÚMERO DE CAS 122752-21-0

N-([R,S]-2-Carboxy-3-Phenylropionyl)-L-Leucinesc-295509Found to be a potent and specific inhibitor of enkephalinase. NÚMERO DE CAS 102601-55-8

N-(2-Aminoethyl) Cyclopaminesc-207900Cyclopamine derivative demonstrating teratogenic properties with reverse effects of oncogenic mutations. NÚMERO DE CAS 334616-31-8

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloridesc-218908Found to have a potent inhibitory action against casein kinase 1 with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases.

N-(2-Mercaptoethyl) Demecolcinesc-218920An antimitotic agent which disrupts microtubles by binding to tubulin and preventing its polyerization. Stimulates the intrinsic GTPase activity of tubulin. NÚMERO DE CAS 1217746-74-1

N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide Hydrochloridesc-207913A neoplasm inhibitor. NÚMERO DE CAS 78957-84-3

N-(4-Azidosalicyl)-6-amido-6-deoxy-glucopyranosesc-207914Inhibits the labeling of the human erythrocyte monosaccharide transporter by [125I]IASA-glc more effectively that D-glucose. NÚMERO DE CAS 86979-66-0

N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamidesc-211996Activates protein kinase C in a Ca2+ -dependent manner via a mechanism similar to that of phosphatidylserine. NÚMERO DE CAS 102649-78-5

N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketonesc-215426Inhibits human granulocyte elastase. NÚMERO DE CAS 65144-34-5

(+/-)-N-3-Benzylnirvanolsc-207943A potent and selective human CYP2C19 inhibitor. NÚMERO DE CAS 93879-40-4

N-Acetyl-2,3-dehydro-2-deoxyneuraminic Acid, Methyl Estersc-219017Bacterial, animal and viral sialidases inhibitor.

N-Acetyl-Asp-Glu-His-Asp-7-amido-4-methylcoumarin trifluoroacetate saltsc-301269

N-Acetyl-L-tyrosine ethyl ester monohydratesc-269703Widely employed substrate for the determination of the esterase activity of chymotrypsin NÚMERO DE CAS 36546-50-6

N-Carboxymethyl-Phe-Leu-OHsc-295684A highly potent enkephalinase inhibitor. NÚMERO DE CAS 81109-85-5

N-Deacetylcolchiceinesc-208016Antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals. NÚMERO DE CAS 3482-37-9

N-Deacetylcolchicinesc-219099Antimitotic agent that intercepts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal. NÚMERO DE CAS 3476-50-4

N-Desethyl Acetildenafilsc-208022A pyrazolopyrimidinone derivative which acts as a cGMP phosphodiesterase inhibitor. NÚMERO DE CAS 147676-55-9

N-Desmethyl Rosuvastatin Disodium Salt Monohydratesc-219129Inhibitor of the enzyme HMG-CoA reductase in vitro.

N-Ethyldeoxynojirimycin Hydrochloridesc-208035Thrombolytic derived from Moranoline wish activity as an HIV cytopathicity inhibitor. NÚMERO DE CAS 210241-65-9

N-Methylaminogenisteinsc-212240 NÚMERO DE CAS 359436-93-4

n-Octyl-Xanthate, Potassium Saltsc-212267 NÚMERO DE CAS 2720-80-1

N-Oxalyl-D-alaninesc-222014Cell permeable, potent competitive inhibitor of factor inhibiting HIF asparagine hydroxylase. But does not inhibit PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).

N-Oxalyl-L-alaninesc-205959Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs). Less potent inhibitor of factor inhibiting HIF asparagine hydroxylase.

N-Oxalylglycinesc-202720A cell permeable α-ketoglutarate analogue that functions as a competitive inhibitor of prolyl 4-hydroxylase which hydroxylates proline-rich peptides in vitro. NÚMERO DE CAS 5262-39-5

3
N-Trifluoroacetyl Deacetylcolchiceinesc-219250An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.

N-Trifluoroacetyl Deacetylcolchicinesc-358439An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.

N-Trifluoroacetyl-N-methyl-deacetylcolchiceinesc-219253An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.

N-Trifluoroacetyl-N-methyl-deacetylcolchicinesc-219254An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.

MM 11253sc-361255This compound is a selective RARγ antagonist which has also been shown to block the growth inhibitory ability of RARγ-selective agonists. NÚMERO DE CAS 345952-44-5

N-Trifluoroacetyliso Deacetylcolchicinesc-219258An antimitotic agent that interrupts microtubles by binding to tubulin and preventing polymerization. Stimulates the intrinsic GTPase activity of tubulin. Apoptosis inducer in normal and tumor cell lines and activates the JNK/SAPK signaling.

N1,N11-Diethylnorspermine tetrahydrochloridesc-204114Highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT), able to increase enzyme activity 200-1000 fold. NÚMERO DE CAS 121749-39-1

N2-Methyl-L-argininesc-204115Selective L-arginine uptake inhibitor (Ki = 500 μM). Inhibits uptake of arginine by the lysosomal system c in human fibroblast in vitro. NÚMERO DE CAS 2480-28-6

N744 tosylatesc-215527An inhibitor of arachidonic acid-induced aggregation of tau proteins. N744 tosylate suppresses microsphere-mediated tau fibrillization via inhibiting the formation of filaments at the surface of microspheres. NÚMERO DE CAS 72616-22-9

Na+/H+ Exchanger Isoform-1 Inhibidorsc-222035A cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells. Exhibits cardioprotective efficacy in both an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo. NÚMERO DE CAS 861218-38-4

MPEP hydrochloridesc-279454MPEP hydrochloride is a potent and selective antagonist of the mGluR5 receptor (metabotropic glutamate receptor subtype 5). NÚMERO DE CAS 96206-92-7

Nalidixic acidsc-219324An inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. NÚMERO DE CAS 389-08-2

Naltrindole Hydrochloridesc-202236Naltrindole Hydrochloride is an apoptotic agent and a cell growth inhibitor. It also has been shown to be a highly potent and selective antagonist of δ opioids (DOR). NÚMERO DE CAS 111469-81-9

Naphthofluoresceinsc-205413Inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.1 The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, are still unknown. NÚMERO DE CAS 61419-02-1

Naringeninsc-219338A flavonoid commonly found in grapefruits which functions as an antioxidant, free radical scavenger, anti-inflammatory compound, carbohydrate metabolism promoter, and immune system modulator. NÚMERO DE CAS 480-41-1

NBI-31772sc-253181An insulin-like growth factor-1 binding proteins (IGFBPs) inhibitor; IGF-1 potentiator. NBI-31772 is an air/DMSO DOPA oxidation product, which inhibits IGF binding to IFGFB's by displacing IGF-1 from IGF1:IGFBP complex. Thus, it increases circulating level of IGF-1. NBI-31772 does not bind to IGFR. NÚMERO DE CAS 374620-70-9

Nebularinesc-208087A naturally occurring nucleoside, which inhibits mouse Sarcoma 180 and mycobacteria. This universal base can bind to all four of the nucleosides of DNA. NÚMERO DE CAS 550-33-4

Necrostatin-7sc-364122 NÚMERO DE CAS 351062-08-3

Neridronatesc-253184A bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta. NÚMERO DE CAS 79778-41-9

Neridronate, Sodium Saltsc-219351A biphosphonate bone resorption inhibitor. Used as a treatment for osteogenesis imperfecta.

NF 340sc-361274NF 340 is a P2Y antagonist demonstrating 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors.

NF 449sc-203159NF 449 is a selective Gsα-subunit G-protein antagonist which reduces the association rate of guanosine 5'-[γ-thio]triphosphate ([35S]GTP[γS]) binding to Gα s -s (Gs&alpha-s) and inhibits the stimulation of adenylyl cyclase activity in S49 cyc- membranes. NÚMERO DE CAS 389142-38-5

NF007sc-222064"Half-molecule" of NF023. Essentially inactive as a G-protein inhibitor and therefore can be used as a negative control.

NFAT Activation Inhibidor IIIsc-203160A potent and selective inhibitor of calcineurin-NFAT signaling that does not effect calcineurin activity or calcineurin’s downstream signaling, NÚMERO DE CAS 3519-82-2

Z-Guggulsteronesc-204414A synthetic form of the guggul tree plant steroid that exhibits an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα). NÚMERO DE CAS 39025-23-5

Nitrogenisteinsc-208101 NÚMERO DE CAS 39679-60-2

Nomilinsc-203163a natural product isolated from grapefruit seed and varying Citrus fruits with activity as an inducer of Phase II detoxifying enzymes and inhibitor of chemically induced carcinogenesis. NÚMERO DE CAS 1063-77-0

NPC-15437 dihydrochloride hydratesc-215587A selective inhibitor of protein kinase C. NÚMERO DE CAS 141774-20-1 (anhydrous)

NS 2028sc-202743Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase. NÚMERO DE CAS 204326-43-2

NSC 632839 hydrochloridesc-204138Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation. NÚMERO DE CAS 157654-67-6

NVP DPP 728 dihydrochloridesc-204141NVP DPP 728 dihydrochloride is a DPP-IV (CD26) inhibitor. NVP DPP 728 dihydrochloride displays >15,000 fold selectivity over DPP-II and a range of Pro-cleaving proteases. NÚMERO DE CAS 247016-69-9

O-Methylviridicatinsc-2022553-O- methylviridicatin is a strong inhibitor of TNFα-induced replication of HIV. NÚMERO DE CAS 6152-51-4

1
Okadaolsc-215623An analogue of okadaic acid (carboxyl group reduced to an alcohol). Has protein phosphatase inhibitory activity approximately 40% that of okadaic acid. NÚMERO DE CAS 131959-12-1

OMDM-2sc-204145Metabolically stable, potent inhibitor of cellular anandamide uptake (neuronal (C6 glioma cells): IC50=3.2µM; non-neuronal (rat RBL-2H3 cells): IC50=17µM) with negligible effects on CB1 receptor (CB1: Ki=5.1µM; CB2: Ki>10µM), TRPV1 (EC50=10µM) and FAAH (IC50>100µM).

Ophiobolin Csc-202268A phytotoxic metabolite from the ophiobolin class produced by many species of the genus Bipolaris. Studies suggest that Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells. NÚMERO DE CAS 19022-51-6

OR-486sc-204149Catechol-O-methyl transferase inhibitor NÚMERO DE CAS 7659-29-2

Oxybutynin Chloridesc-208141This compound inhibits proliferation and supresses gene expression in bladder smooth muscle cells. NÚMERO DE CAS 1508-65-2

Ozagrel hydrochloride hydratesc-215645An selective inhibitor of thromboxane A2 synthase (TXA2). NÚMERO DE CAS 78712-43-3

Pamidronic Acidsc-219549A biphosphonate bone resorption inhibitor. NÚMERO DE CAS 40391-99-9

Paraoxonsc-208151Cholinesterase inhibitor. NÚMERO DE CAS 311-45-5

Patulinsc-204833A mycotoxin that has been reported to contain antibiotic characteristics. Also shown to specifically inhibit Na+-K+ ATPase activity. NÚMERO DE CAS 149-29-1

PD 123319 ditrifluoroacetatesc-204835PD 123319 ditrifluoroacetate is a potent, selective non-peptide angiotensin AT2 receptor antagonist. Tested on rat adrenal tissue and brain. This compound prevents the binding of angiotensin II to the receptor, which blocks signal transduction and causes vasodilation. NÚMERO DE CAS 130663-39-7

Perindoprilatsc-208160Perindoprilat is an active metabolite of Perindopril, an angiotensin converting enzyme (ACE) inhibitor, which modulates the activity of Low density lipoprotein receptor-related protein (LRP). NÚMERO DE CAS 95153-31-4

Phalloidin Oleatesc-222153Phalloidin oleate is a semi-synthetic derivative of Phalloidin (sc-202763) that is about 100-fold more cell-permeable than Phalloidin with similar acting binding properties.

Phenoxymethylpenilloic Acidsc-208165A reversible competitive inhibitor of Penicillinase, β-Lactamase 1. NÚMERO DE CAS 4847-29-4

Phosphoramidon, Disodium Saltsc-222168Inhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM). Effective concentration: 1-10 µM.

Pimprininesc-202288Indole alkaloid produced by many species of Streptomyces. Inhibitor of monoamine oxidase and has shown antiepileptic effects. Inhibited tremorine-induced tremors and analgesia in mice. NÚMERO DE CAS 13640-26-1

Plumbagin from Plumbago indicasc-253283Exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action. NÚMERO DE CAS 481-42-5

Polydatinsc-203203The glycoside of Resveratrol (sc-200808) originally isolated from the Chinese herb Polygonum cuspidatum. The compound has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. NÚMERO DE CAS 65914-17-2

POM 1sc-203205POM 1 is a polyoxotungstate that inhibits CD39, CD39L1, CD39L3 (nucleoside-triphosphate-diphosphohydrolases) and blocks the breakdown of ATP activated by ischemic preconditioning (IP). NÚMERO DE CAS 12141-67-2

Propentofyllinesc-208188A c-AMP phosphodiesterase inhibitor, a nerve growth factor stimulator, an adenosine transport inhibitor and a non-selective adenosine receptor antagonist. Nootropic. NÚMERO DE CAS 55242-55-2

Protein Synthesis Initiation Inhibidor, NSC 119889sc-222203A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5'-mediated/cap-dependent initiation of protein synthesis.

Protopanaxatriolsc-204866May be an inhibitor of the uptake of glucose. NÚMERO DE CAS 34080-08-5

PSB 06126sc-204215PSB 06126 is a nucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) inhibitor. This compound has been reported to inhibit rat NTPDase 3 at low micromolar concentrations and display selectivity over NTPDase 1 and NTPDase 2.

PSB 069sc-204216PSB 069 is a non-selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor. This compound has been reported to inhibit rat NTPDases 1, 2 and 3 with similar potencies. NÚMERO DE CAS 1052089-16-3

PSC 833sc-361298PSC 833 P-glycoprotein (P-gp, Mdr-1) modulator shown to inhibit P-gp-mediated multidrug-resistance (MDR). NÚMERO DE CAS 121584-18-7

Purpurinsc-205822A xanthine oxidase inhibitor that inhibits azoxymethane-induced aberrant crypt foci in the rat. NÚMERO DE CAS 81-54-9

Pyrenophorolsc-364130 NÚMERO DE CAS 155326-45-7 and 22248-41-5

Pyridostigmine bromidesc-212607An inhibitor of acetylcholinesterase. NÚMERO DE CAS 101-26-8

Pyripyropene Asc-202302Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2) NÚMERO DE CAS 147444-03-9

Pyrroloquinoline quinonesc-210178A cofactor of microbial quinoprotein enzyme, and imidazopyrroline. A redox/cofactor found in a a class of enzymes called quinoproteins. NÚMERO DE CAS 72909-34-3

R-(+)-Aminoglutethimide L-Tartrate Saltsc-208199An inhibitor of aromatase. Also blocks adrenal steroidogenesis. NÚMERO DE CAS 57344-88-4

R-(+)-Etomoxirsc-208201An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oxidation of long-chain acyl CoA esters. Also a strong inhibitor of mitochondrial CPT1 and a candidate as an anti-diabetic drug. NÚMERO DE CAS 124083-20-1

R-(+)-Etomoxir Carboxylate, Potassium Saltsc-219696 NÚMERO DE CAS 132308-39-5

(R,S)-Equolsc-202307Flavonoid. Racemic mixture. Inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signaling pathway. NÚMERO DE CAS 94105-90-5

(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanolsc-219717A MEK inhibitor NÚMERO DE CAS 14347-78-5

(R)-(-)-Ibuprofen (S)-(+)-Lysinatesc-219722A nonsteroidal anti-inflammatory drug (NSAID). Optically active, selective cyclooxygenase inhibitor (IC50=14.9μM), that inhibits PGH synthase-1 and PGH synthase-2 with equal potency.

(R)-(-)-N-3-Benzylnirvanolsc-208219A potent and selective human CYP2C19 inhibitor. NÚMERO DE CAS 790676-41-4

(R)-(+)-Acenocoumarolsc-205484A short-lived oral anti-coagulant, which functions by inhibiting vitamin K epoxide reductase. NÚMERO DE CAS 66556-77-2

(R)-(+)-Blebbistatin O-Benzoatesc-219729Derivative of Blebbistatin, which is a compound that blockes myosin II-dependent cell processes.

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazinesc-219735An inhibitor with anti-tumor activity. NÚMERO DE CAS 109838-85-9

(R)-Omeprazole Sodium Saltsc-208250The R-Form of Omeprazole. Acts as a gastric proton-pump inhibitor. NÚMERO DE CAS 161796-77-6

(R)-Oxybutynin Chloridesc-219762The optically active inhibitor of proliferation and it also suppresses gene expression in bladder smooth muscle cells.

Rabeprazole Sodium Saltsc-208255A partially reversible gastric proton pump inhibitor. NÚMERO DE CAS 117976-90-6

rac Atomoxetine Hydrochloridesc-212721A derivative of Tomoxetine. NÚMERO DE CAS 82857-40-7

rac Kainic Acidsc-212731A neuroexcitatory chemical that is selective for the kainic acid receptor. NÚMERO DE CAS 73209-05-9

rac-Sitagliptinsc-208294A trizolopyrazine dipeptidyl peptidase IV inhibitor (DPP-4). DPP-4 is an enzyme which breaks down incretins such as GLP-1, GIP, and gastrointestinal hormones. NÚMERO DE CAS 823817-56-7

Racecadotrilsc-205831A potent enkephalinase inhibitor which exhibits selective antisecretory activity. NÚMERO DE CAS 81110-73-8

Raltegravir Potassium Saltsc-208296A potent human immunodeficiency virus (HIV) integrase inhibitor and a novel anti-AIDS drug. NÚMERO DE CAS 871038-72-1

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Ras/Rac Transformation Blocker, SCH 51344sc-204231A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. NÚMERO DE CAS 171927-40-5

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Resibufogeninsc-202788Specific Na+/K+-ATPase inhibitor. NÚMERO DE CAS 465-39-4

Rho Kinase Inhibidor IIsc-222253A pyridyl urea compound that acts as a potent, selective, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK). Displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR.

Risedronate sodiumsc-204880A pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption. NÚMERO DE CAS 115436-72-1

Ro 08-2750sc-203682Ro 08-2750 is a TrkA inhibitor, preventing NGF-induced apoptosis. NÚMERO DE CAS 37854-59-4

Ro 23-9358sc-215815A Diacylglycerol lipase inhibitor which is an anti-obesity drug target. NÚMERO DE CAS 153125-17-8

Ro 26-4550 trifluoroacetatesc-204888Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2. NÚMERO DE CAS 193744-04-6

Ro 41-1049 hydrochloridesc-215816A selective, reversible, orally active inhibitor of MAO-A. NÚMERO DE CAS 127500-84-9

Rotenonesc-203242A mitochondrial electron transport inhibitor, which specifically inhibits NAD-linked substrate oxidation of NADH dehydrogenase with an EC50=10pmol/mg. NÚMERO DE CAS 83-79-4

RS 102895 Hydrochloridesc-204243CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Inhibits α1A, α1D and 5-HT1A receptors. NÚMERO DE CAS 300815-41-2

RS 504393sc-204245A CCR2 chemokine receptor antagonist, shown to also inhibit MCP-1 chemotaxis. NÚMERO DE CAS 300816-15-3

RWJ 50271sc-362792RWJ 50271 is a selective inhibitor of LFA-1 adhesion to intercellular adhesion molecule (sICAM) (IC50 = 5 μM) in HL60 cells). NÚMERO DE CAS 162112-37-0

S-(-)-Aminoglutethimide L-Tartrate Saltsc-208318An aromatase inhibitor. Also blocks adrenal steroidogenesis. NÚMERO DE CAS 62268-19-3

S-(+)-Etomoxirsc-220002An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug. NÚMERO DE CAS 828934-40-3

(S)-(-)-Blebbistatinsc-204253Selective inhibitor of myosin II. Active enantiomer. Inhibits contraction of cleavage furrow sans disruption of mitosis or of the contractile ring assembly. Rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells. NÚMERO DE CAS 856925-71-8

(S)-(-)-Blebbistatin O-Benzoatesc-220036A derivative of Blebbistatin, a compound that blockes myosin II-dependent cell processes.

(S)-(+)-Ibuprofen (S)-(+)-Lysinatesc-220042A nonsteroidal anti-inflammatory drug (NSAID). Optically active, selective cyclooxygenase inhibitor (IC50=14.9μM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.

(S)-(+)-N-3-Benzylnirvanolsc-220043Potent and selective human CYP2C19 inhibitor. NÚMERO DE CAS 790676-40-3

(S)-(+)-α-Fluoromethylhistidine Dihydrochloridesc-220045A histidine carboxylase inhibitor.

(S)-(−)-Acenocoumarolsc-205501Acenocoumarol is a short-lived oral anti-coagulant, which functions by inhibiting vitamin K epoxide reductase. NÚMERO DE CAS 66556-78-3

(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamidesc-212889A potent and efficacious KCNQ2 opener that inhibits induced hyperexcitability of rat, hippocampal neurons. NÚMERO DE CAS 697287-41-5

(S)-Oxybutynin Chloridesc-220080The optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.

Sandoz 58-035sc-215839An inhibitor of Acyl-CoA cholesterol acyltransferase (ACAT). NÚMERO DE CAS 78934-83-5

Sanguinarine chloridesc-202800Sanguinarine is a benzophenanthridine alkaloid and potent, noncompetitive Na+/K+ ATPase inhibitor with anticancer properties. NÚMERO DE CAS 5578-73-4

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(Sar1,Gly8)-Angiotensin IIsc-296370Part peptide (Sar-Arg-Val-Tyr-Ile-His-Pro-Gly) Acetate Salt Inhibitor of Angiotensin II. NÚMERO DE CAS 100900-29-6

SB 225002sc-202803A selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. NÚMERO DE CAS 182498-32-4

SB 265610sc-361341SB 265610 is a benzotriazole derivative shown to act as a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization with IC50 values of 3.4 and 6800 nM respectively. This compound has also been shown to inhibit CINC-induced chemotaxis and attenuate neutrophil accumulation in inflammatory lung injury in animal models. NÚMERO DE CAS 211096-49-0

SB 328437sc-222292A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis. NÚMERO DE CAS 247580-43-4

SB 431542sc-204265A small molecule that acts as a specific and selective inhibitor of TGF-β superfamily type I ALK receptors ALK4, 5, and 7. NÚMERO DE CAS 301836-41-9

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SB366791sc-364136SB366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research. NÚMERO DE CAS 472981-92-3

SB-415286sc-204901SB-415286 is an ATP-competitive inhibitor of Glycogen Synthase Kinase 3α (GSK3α) with a Ki value of 31 nM. NÚMERO DE CAS 264218-23-7

SCH 28080sc-204269Potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo. NÚMERO DE CAS 76081-98-6

Sch 58053sc-208384Ezetimibe analog and intestinal lymphatic cholesterol transporter inhibitor (potent, rapid, and selective) NÚMERO DE CAS 194423-53-5

sFRP-1 Inhibidorsc-222310A cell-permeable diphenylsulfone-sulfonamide compound that acts as a selective and reversible inhibitor of sFRP-1, and potently activates canonical Wnt pathway. Shows a desirable aqueous solubility and in-vitro microsomal stability-human. Marginally affects cytochrome p450 isozymes. NÚMERO DE CAS 915754-88-0

Shz-1sc-364137 NÚMERO DE CAS 326886-05-9

Siastatin B microbialsc-215851A broad spectrum inhibitor of sialidase. NÚMERO DE CAS 54795-58-3

SID 7969543sc-204278Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM). NÚMERO DE CAS 868224-64-0

Sitagliptin Phosphatesc-208391A trizolopyrazine dipeptidyl peptidase IV inhibitor that has recently been approved for type II diabetes therapy. NÚMERO DE CAS 654671-78-0

Sivelestat sodium salt hydratesc-215858A competitive inhibitor of human neutrophil elastase (HNE), that has also been shown to inhibit leukocyte elastase obtained from several animal donors. NÚMERO DE CAS 201677-61-4

SKF 91488 dihydrochloridesc-203696This homologue of dimaprit is a strong inhibitor of histamine N-methyltransferase, with no histamine agonist activity. NÚMERO DE CAS 68643-23-2

SM-19712sc-215859A potent and selective nonpeptide endothelin converting enzyme inhibitor. NÚMERO DE CAS 194542-56-8

SMI-4asc-364140 NÚMERO DE CAS 327033-36-3

Sodium Copper Chlorophyllinsc-205628A water soluble salt of chlorophyll which inhibits activation and degradation of electrophyllic intermediates. NÚMERO DE CAS 28302-36-5

Sodium Phenylacetatesc-296401An aromatic fatty acid, which displays cell growth inhibition, malignant phenotype reduction and cell differentiation. NÚMERO DE CAS 114-70-5

Steroidogenic Factor-1 Inhibidor, SID7970631sc-311539A cell-permeable isoquinolinone compound that inhibits SF-1 functional activity. NÚMERO DE CAS 868224-75-3

Strontium Ranelatesc-208403A bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Commonly used as an antiosteoporotic. NÚMERO DE CAS 135459-87-9

Sulbactamsc-272516 NÚMERO DE CAS 68373-14-8

Suplatast tosylatesc-204315Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Shows antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active. NÚMERO DE CAS 94055-76-2

(+/-)-Synephrinesc-220182A α-adrenergic receptor agonist, vasoconstrictor. NÚMERO DE CAS 94-07-5

T0070907sc-203287Cell-permeable. Potent, specific, irreversible, and high-affinity antagonist of PPARγ. NÚMERO DE CAS 313516-66-4

Talsaclidine Hydrochloridesc-220185A novel M1-receptor selective muscarinic agonist for cholinergic substitution used in the therapy for Alzheimer's disease. Treatment decreases cerebrospinal fluid levels of A beta 42 in patients.

TAS-301sc-215942Inhibits migration and proliferation in vascular smooth muscle cells and also inhibits restenosis. NÚMERO DE CAS 193620-69-8

Taurinesc-202354Inhibitor of lipid peroxidation. Inhibits diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis. NÚMERO DE CAS 107-35-7

TCS PrP Inhibidor 13sc-204331Antiprion agent that potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50= 3 nM). NÚMERO DE CAS 34320-83-7

Teijin compound 1sc-301864A potent chemokine CCR2b receptor antagonist (IC50 = 180 nM). Shown to potently inhibit cell chemotaxis induced by MCP-1 (EC50 = 24 nM). NÚMERO DE CAS 226226-39-7

Telmisartansc-204907Angiotensin II receptor antagonist that inhibits the angiotensin II AT1 receptor. NÚMERO DE CAS 144701-48-4

Tetraisopropyl Dichloromethylene Diphosphonatesc-220223An intermediate in the sythesis of Clodronic Acid, Disodium Salt, Tetrahydrate, which is a biphosphonate bone resorption inhibitor. NÚMERO DE CAS 10596-22-2

Tetraisopropyl pyrophosphoramidesc-215956A selective inhibitor of butyrylcholinesterase. NÚMERO DE CAS 513-00-8

Tetramisole hydrochloridesc-215963Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor)(Intestinal alkaline phosphatases are only slightly inhibited.) NÚMERO DE CAS 5086-74-8

Thielavin Bsc-202362Thielavin B is a potent prostaglandin (PG) synthetase inhibitor derived from Thielavia terricola. Studies show that Thielavins B inhibits Phospholipase C (PLC) as well as the synthesis of prostaglandin E2 NÚMERO DE CAS 71950-67-9

Tie-2 Inhibidor 13sc-358703Shown to be a potent and cell permeable Tie-2 inhibitor (IC50=600nm). NÚMERO DE CAS 857250-95-4

Tie-2 Inhibidor 7sc-202363A compound that can permeate the cell (IC50= 1uM) and inhibit endothelial cell tube formation. NÚMERO DE CAS 1020412-97-8

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Tipranavirsc-220260Nonpeptidic HIV protease inhibitor (NPPI). Antiviral. NÚMERO DE CAS 174484-41-4

TJU103sc-222358This is a non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, which suggests that its potential as a novel immunosuppressant. It does not exhibit any toxic effects in vivo, with normal lymphocyte cellularity and subset composition in the spleen and lymph nodes of mice 24 h after injection.

TNP-AECM-FICOLLsc-281696TNP (2,4,6-Trinitrophenyl) hapten is conjugated to AminoEthylCarboxyMethyl-FICOLL (AECM-FICOLL), a high molecular weight polysaccharide; useful as T-independent antigens for studying B lymphocyte activation.

TNP(12)-BSA (Bovine Serum Albumin)sc-281697A compound used to elicit an immune response in research animals. Contains a 2,4,6-Trinitrophenyl hapten, which is conjugated to bovine serum albumin. TNP to BSA molar ratio is approximately 12. For higher molar ratio, please see sc-360249 (molar ratio approximately 26).

TNP(21-31)-BSA (Bovine Serum Albumin)sc-362049A compound used to elicit an immune response in research animals. Contains a 2,4,6-Trinitrophenyl hapten, which is conjugated to bovine serum albumin. TNP to BSA molar ratio is approximately 26. For a lower molar ratio, please see sc-281697 (molar ratio approximately 12).

Tolterodine L-Tartratesc-220271Tolterodine L-Tartrate is a muscarinic receptor antagonist that blocks action by acetylcholine at mAChR M. NÚMERO DE CAS 124937-52-6

Torsemidesc-213059Used as a diuretic. NÚMERO DE CAS 56211-40-6

trans-HR22C16sc-202842Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=800nM) by binding to the mitotic kinesin Eg5. NÚMERO DE CAS 462630-41-7

Triflumuronsc-205873Chitin biosynthesis inhibitor. Has displayed to inhibit uridine incorporation into RNA. NÚMERO DE CAS 64628-44-0

Trilostanesc-208469An inhibitor of isoforms 3β-HSD and 3β-HSD2 of 3β-hydroxysteroid dehydrogenase. A useful tool in steroid biosynthesis research. NÚMERO DE CAS 13647-35-3

Triparanolsc-208472An inhibitor of delta 24-reductase and an inhibitor of cholesterol biosynthesis. Described to inhibit Hedgehog pathway signaling and useful as a probe for studying the pathway. NÚMERO DE CAS 78-41-1

Tris DBAsc-204355N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Used as a cyclization catalyst. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. NÚMERO DE CAS 52522-40-4

Tubulozole-T hydrochloridesc-216030An anti-malarial agent that does not inhibit microtubule assemby. An inactive trans-isomer of tubulozole-C . NÚMERO DE CAS 95480-32-3

Ubiquinone-10sc-202375Inhibitor of the mitochondrial permeability transition pore (MPTP). This inhibitory effect can be counteracted by ubiquinone-5 NÚMERO DE CAS 606-06-4

Ubiquitin Isopeptidase Inhibidor II, F6sc-296678Cell-permeable cross-conjugated alpha,beta-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 15.65 and 16.23 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway, selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for F6-activated apoptosis, while Bcl-2 appears to protect cells against the effect of F6. NÚMERO DE CAS 157654-67-6 (HCl salt)

UBP 310sc-361389UBP 310 is a GLUK5 kainate receptor antagonist with an IC50 of ~ 130 nM. This compound has also been shown to block recombinant homomeric GLUK7 receptors, displays 12,700-fold selectivity for GLUK5 over GLUK6, and does not exhibit any activity at mGlu group I or NMDA receptors at concentrations of up to 10 µM.

UCB 35625sc-204369Potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM). Isomer of J 113863 (sc-203611). NÚMERO DE CAS 301648-08-8

UCPH 101sc-361391UCPH 101 is a selective non-substrate inhibitor of EAAT1. NÚMERO DE CAS 1118460-77-7

V2R Antagonist, V2Rnh-02sc-222408This is a pyrrolone compound that acts as a ligand-competitive vasopressin receptor antagonist with ~70-fold greater affinity for V2R than V1aR (IC50 against arginine vasopression binding = 70 nM and 5 µM, respectively). It has shown to selectively inhibit cellular cAMP production mediated by V2R (IC50 = 60 nM), but not β2-adrengergic receptor. It is reported to exhibit great aqueous solubility (377 µM in PBS) with a pKa of 4.76.

Vatalanib Dihydrochloridesc-202379Vandetanib dihydrochloride inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation by preventing the autophosphorylation of these receptors. NÚMERO DE CAS 212141-51-0

VER 155008sc-358808VER 155008 is a novel adenosine-derived inhibitor of HSP 70 (heat shock protein 70) (IC50 = 0.5 μM). NÚMERO DE CAS 1134156-31-2

VER-50589sc-296692The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM. It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-50589 induces the expression of HSP27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals. Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589. NÚMERO DE CAS 747413-08-7

VU0155069sc-224371VU0155069 is a potent and specific inhibitor of phospholipase D1 (PLD1). VU0155069 significantly decreases invasive migration in breast cancer cell lines. NÚMERO DE CAS 1130067-06-9

W140 trifluoroacetate saltsc-296699Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 (trifluoroacetate salt) is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 µM (2a = W146; 2b = W140 in supplemental material). It exhibits no biological activity in vivo and can therefore serve as an effective control compound for experiments involving W146.

Wnt Agonistsc-222416Wnt Agonist is a cell-permeable compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β.

Wnt Synergist, QS11sc-222417A cell-permeable purine compound that binds GTPase activating proteins of ADP-ribosylation factor and acts as a broad specificity ARFGAPs inhibitor. NÚMERO DE CAS 944328-88-5

XR 9051 HClsc-361409XR 9051 HCl has been shown to inhibit the binding of cytotoxics to P-glycoprotein. NÚMERO DE CAS 180422-22-4

Y-29794 oxalatesc-204408Prolyl endopeptidase inhibitor, a serine peptidase that may be implicated in the biosynthesis of amyloid b-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid b-peptide deposition in vivo. Orally active and brain penetrant. NÚMERO DE CAS 129184-48-1

YIC-C8-434sc-216068Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. NÚMERO DE CAS 214265-97-1

YM-53601sc-205543YM-53601 inhibits squalene synthase activity in rat hepatic microsomes and human HepG2 cells. Displaying an ED50 value of 32 mg/kg of YM-53601, cholesterol biosynthesis is inhibited, causing a reduction in both cholesterol and triglyceride levels in plasma. Cholesterol-reducing HMG-CoA reductase inhibitors are often paired with fibrates, which can have adverse effects, to treat hyperlipidemia. NÚMERO DE CAS 182959-33-7

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γ-Secretase Inhibidor Isc-301796γ-Secretase Inhibitor is an inhibitor of γ-secretase, a protease that cleaves the amyloid precursor protein (APP). NÚMERO DE CAS 133407-83-7

Z-Gly-Phe-NHO-Bzsc-358593Z-Gly-Phe-NHO-Bz has been shown to Inhibit Cathepsin L, Cathepsin S, Cathepsin B.

Z-Phe-Tyr(tBu)-diazomethylketonesc-222423An irreversible inhibitor of cathepsin L.

Z-Val-Val-Nle-diazomethylketonesc-301998An irreversible cathepsin inhibitor that is 380 times more effective in inactivating cathepsin S than L. Is often abbreviated as DMK. Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

(Z)-Pugnacsc-204415An inhibitor of O-GlcNAcase, an enzyme which removes the N-acetylglucosamine moieties from 2-acetamido-2-deoxy-&beta-D-glucopyranose (O-GlcNAc) bound to proteins that were modified by O-GlcNAc. NÚMERO DE CAS 132489-69-1

Zatebradine hydrochloridesc-203724Bradycardic agent that creates use-dependent inhibition of hyperpolarization-activated current (If) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM). NÚMERO DE CAS 91940-87-3

Zofenopril Calcium Saltsc-208496An antioxidant that acts as an angiotensin-converting enzyme inhibitor. NÚMERO DE CAS 81938-43-4

Zoledronic Acid, Disodium Salt, Tetrahydratesc-208497A biphosphonate bone resorption inhibitor. NÚMERO DE CAS 165800-07-7

Zolmitriptansc-220415A Serotonin 5HTID-receptor agonist. NÚMERO DE CAS 139264-17-8

Zoniporide dihydrochloridesc-204423Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor NÚMERO DE CAS 241800-97-5 (anhydrous)