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Immunomodulators

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NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
Anisomycinsc-3524Anisomycin is shown to strongly activate the stress-induced MAP kinases JNK (c-Jun N-terminal kinases) and p38. NÚMERO DE CAS 22862-76-6

14
17(R)-Resolvin D1sc-358747Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. 17(R)-Resolvin D1 is an aspirin-triggered epimer of resolvin D1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to resolvin D1 (EC50 ~30 nM). 17(R)-Resolvin D1 exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with maximal inhibition of ~35% at a 100 ng dose. In contrast to resolvin D1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. NÚMERO DE CAS 528583-91-7

α-Mannosyl Ceramidesc-221189α-Mannosyl Ceramide is a strong stimulator of NKT cells expressing the invariant Vα19-Jα26 T cell receptor α chain.

Acetyl-Cys(dodecyl) chloromethyl ketonesc-300165A potent cytotoxic chloromethylketone used against human-lineage and T-lineage acute lymphoblastic leukemia cell lines. NÚMERO DE CAS 253589-60-5

Bis(methylthio)gliotoxin (FR-49175)sc-201027Bis(methylthio)gliotoxin (FR-49175) is analog of gliotoxin shown to inhibit PAF-induced platelet aggregation and speed up PAF hydrolysis. NÚMERO DE CAS 74149-38-5

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1α,25-Dihydroxyvitamin D3 (Calcitriol)sc-2004191α,25-Dihydroxyvitamin D3 (Calcitriol) is a metabolite of vitamin D3 and the active form of the hormone. Regulates transport and use of calcium in bone development. NÚMERO DE CAS 32222-06-3

1
B-Cell Immunosuppressantsc-221282A cell-permeable quinolinecarboxamide that acts as a potent and highly selective B-cell immunosuppressant with a 75-fold selectivity for B- over T-cells and no general cytotoxicity.

C5a Receptor Antagonist, W-54011sc-203863A potent, specific, and orally active C5a receptor antagonist. NÚMERO DE CAS 405098-33-1

Ds(+)-threo-Isocitric acidsc-364109 NÚMERO DE CAS 903507-52-8

Conglobatinsc-202112An unusual dimeric macrolide dilactone structure with pendant oxazole groups that has displayed immunosuppressant activity. NÚMERO DE CAS 72263-05-9

Ethyl 3,4-Dihydroxycinnamatesc-205930Ethyl 3,4-Dihydroxycinnamate is an inhibitor of NF-κB and its downstream inflammatory mediators: iNOS, NOS II, Cox-2 (cyclooxygenase-2), and prostaglandin E2. NÚMERO DE CAS 66648-50-8

Imiquimodsc-200385Imiquimod is a TLR7 (toll-like receptor 7) activator. Inhibits angiogenesis, induces apoptosis and modifies the immune response. Suggested to activate caspase-3 and NFκB. NÚMERO DE CAS 99011-02-6

Cyclosporinesc-358111 NÚMERO DE CAS 79217-60-0

Ellipticinesc-200878Ellipticine is a polyaromatic DNA intercalator. Ellipticine inhibits Topo II (DNA topoisomerase II), cytochrome p450 CYP1A1 activity and blocks p53 protein phosphorylation. NÚMERO DE CAS 519-23-3

Flunisolidesc-215039 NÚMERO DE CAS 3385-03-3

Piceatannolsc-200610Piceatannol is a catechol-type polyphenol that preferentially inhibits Syk in comparison to Lyn. Also inhibits NF-κB activation and cyclooxygenase-2 expression. NÚMERO DE CAS 10083-24-6

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Gliotoxinsc-201299Gliotoxin is a toxic epipolythiodioxopiperazine metabolite shown to be an immunosuppressive mycotoxin. Displays a capacity to induce apoptosis and inhibit NF-κB activation. NÚMERO DE CAS 67-99-2

FTY720sc-202161FTY720 is an aminopropanediol cell-permeable EDG-1 (endothelial differential gene 1 receptor) antagonist and immunosuppresive agent. It has been shown to display lymphocyte, or white blood cell, sequestration properties. NÚMERO DE CAS 162359-56-0

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FTY720 (S)-Phosphatesc-205331FTY720 (S)-Phosphate is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. A potent agonist at EDG-1, -3, -4 and -5. NÚMERO DE CAS 402616-26-6

Furaltadonesc-215062 NÚMERO DE CAS 139-91-3

Furaltadone (+)-tartrate saltsc-215063 NÚMERO DE CAS 14343-71-6

Pentoxifyllinesc-203184Pentoxifylline is a non-selective PDE (phosphodiesterase) inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-a. PTX inhibits the adhesion of T cells to the b1 and b2 Integrin ligands VCAM-1, ICAM-1. NÚMERO DE CAS 6493-05-6

GR 144053 trihydrochloride hydratesc-300772This product is a non-peptide glycoprotein (GP) IIb/IIIa fibrinogen receptor antagonist. NÚMERO DE CAS 201304-22-5 (anhydrous)

W146 trifluoroacetate saltsc-296700W146 is an EDG-1 (S1P1) receptor antagonist that exhibits a Ki value of 77 nM.

H-Leu-Leu-OMe HClsc-285992Possesses immunosuppressive activity. NÚMERO DE CAS 16889-14-8

Mitoxantrone Dihydrochloridesc-203136Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, Topo II inhibitor, and antineoplastic cytostatic anthraquinone derivative. NÚMERO DE CAS 70476-82-3

Hymenistatin Isc-300819This product exerts an immunosuppressive effect on humoral and cellular immune responses similar to cyclosporin A.

IDR-1sc-300822IDR-1 is an anti-infective peptide that acts on the host to stimulate the innate immune response. It is believed to act by enhancing monocyte chemokines, while reducing pro-inflammatory cytokines (decreased TNF and IL-6 and increased IL-10). NÚMERO DE CAS 940291-10-1

Loganinsc-202696An iridoid glucoside that has been reported to be an inhibitor of Cox-1 and noted to suppress TNF-α formation. Also shown to down-regulate expression of caspase-3, caspase-9, and RANKL. NÚMERO DE CAS 18524-94-2

Doxorubicin • HCl (Adriamycin)sc-200923Doxorubicin is a DNA intercalator and broad-spectrum antitumor agent. Shown to downregulate expression of the oncogenes c-Myc and c-Jun and inhibit Topo II (Topoisomerase II). NÚMERO DE CAS 25316-40-9

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[Met210]-Melanocyte Protein PMEL 17 Fragment 209-217 humano, ratónsc-300961Modification of the melanoma differentiation antigen gp100/PMEL 17 fragment 209-217 sequence with greater affinity for the HLA-A2 molecule than the unmodified peptide. Has an increased ability to generate melanoma-reactive cytotoxic T lymphocytes in vitro.

Bestatin hydrochloridesc-200564Bestatin hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase (LTA4). NÚMERO DE CAS 65391-42-6

Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate saltsc-301799Selective proteinase-activated receptor 2 (PAR2) peptide agonist. NÚMERO DE CAS 171436-38-7 (non-salt)

TJU103sc-222359This is a non-peptidic, non-toxic organic compound that specifically blocks stable CD4-MHC class II binding. It also exhibits significant inhibition of immune response in animal models of autoimmune disease.

Z-Ala-Ser-Thr-Asp(OMe)-fluoromethyl ketonesc-301991This product is a cell permeable inhibitor of endothelial monocyte-activating polypeptide II (EMAP-II).

Cord Factorsc-202555Immunomodulatory compound. Induces activation of macrophages independent of TLR2 or TLR4. NÚMERO DE CAS 61512-20-7

Canavanine sulfatesc-202983Canavanine sulfate is reported to be a selective inhibitor of NOS2 (iNOS) due to its structural mimicry of the native NOS2 substrate L-arginine. NÚMERO DE CAS 2219-31-0

Myriocin (ISP-1)sc-201397Myriocin is a small molecule inhibitor of SPTLC (serine palmitoyltransferase), necessary for sphingolipid biosynthesis. A tool for depleting cells of sphingolipids. NÚMERO DE CAS 35891-70-4

LY223982sc-221865LY223982 is a potent P2Y7 (BLT1) receptor antagonist and benzophenone dicarboxylic acid derivative. NÚMERO DE CAS 117423-74-2

Swainsoninesc-201362Swainsonine is a potent MAN2A1 (α-mannosidaseII) inhibitor and immunomodulator. Also has been reported to inhibit the breakdown of glycoprotein by isolated rat liver lysosomes. NÚMERO DE CAS 72741-87-8

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SEW2871sc-203251SEW2871 is a selective agonist of EDG-1 (Sphingosine-1-phosphate receptor 1; S1P1). Useful tool for elucidating the cardiovascular regulatory behaviors of EDG-1. NÚMERO DE CAS 256414-75-2

Elaiophylinsc-202147A highly characteristic macrolide antibiotic with antifungal, antitumor, anithelminthic and immunosuppressant properties. NÚMERO DE CAS 37318-06-2

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R-848sc-203231R-848 is a low-molecular-weight immune response modifier. A TLR7 and TLR8 (Toll-like receptor) activator. It is reported to possess anti-tumor and anti-viral properties. NÚMERO DE CAS 144875-48-9

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L-Kynureninesc-202688Key intermediate in the breakdown pathway of tryptophan. NÚMERO DE CAS 2922-83-0

AS 101sc-203825Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1a, IL-2 and TNFa release NÚMERO DE CAS 106566-58-9

Eicosa-11Z,14Z-dienoic Acidsc-200776Eicosa-11Z,14Z-dienoic acid is a polyunsaturated lipid analog of arachidonic acid. It has been shown to inhibit calcineurin. NÚMERO DE CAS 2091-39-6

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Eicosa-11Z,14Z,17Z-trienoic Acid (20:3, n-3)sc-200778Eicosa-11Z,14Z,17Z-trienoic Acid (20:3, n-3) is a structural analogue of arachidonic acid lacking C-5 and C-6 double bonds. NÚMERO DE CAS 2091-27-2

Mead Acid (20:3, n-9)sc-200772Mead Acid (20:3, n-9) is an unsaturated fatty acid which is a precursor in the biosynthesis of prostaglandins, thromboxanes and leukotrienes (the eicosanoids comprising the "arachidonic cascade"). NÚMERO DE CAS 20590-32-3

NFAT Activation Inhibidor IIIsc-203160A potent and selective inhibitor of calcineurin-NFAT signaling that does not effect calcineurin activity or calcineurin’s downstream signaling, NÚMERO DE CAS 3519-82-2

γ-Linolenic Acid (18:3, n-6)sc-200774γ-Linolenic Acid is an antiinflammatory unsaturated fatty acid that inhibits NFκB and activator protein-1. Also an inducer of reactive oxygen species generation. NÚMERO DE CAS 506-26-3

Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Strandedsc-204854Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded is a TLR3 (Toll-like receptor 3) agonist. NÚMERO DE CAS 42424-50-0

2-Acetyl-4-tetrahydroxybutylimidazolesc-2802622-Acetyl-4-tetrahydroxybutylimidazole is an SP-lyase (sphingosine-1-phosphate lyase) inhibitor. NÚMERO DE CAS 94944-70-4

7-Bromo-5-fluoroindolesc-300066 NÚMERO DE CAS 408355-23-7

Loxoribinesc-203118Loxoribine is an immunostimulant and selective agonist for TLR7 (Toll-like receptor 7) with antitumor and antiviral properties. NÚMERO DE CAS 121288-39-9

Pam3Cys-Ser-(Lys)4 trihydrochloridesc-202271Pam3Cys-Ser-(Lys)4 trihydrochloride has shown to be a potent activator of BALB/c splenocytes in vitro and an agonist of TLR1/2 (Toll-like receptor 1 and 2 complex). NÚMERO DE CAS 112208-00-1 (non-salt)