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EGFR Inhibidores

We now offer a broad range of EGFR Inhibitors. The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Upregulation of EGFR is associated with tumor progression. Abrogation of EGFR may be achieved with the use of EGFR Inhibitors with potential results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells. EGFR Inhibitors offered by Santa Cruz inhibit EGFR and, in some cases, other receptor tyrosine kinases and tumor progression related proteins. View detailed EGFR Inhibitor specifications, including EGFR Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by linking to the specific product blocks.

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Para el análisis funcional de losEGFR Inhibidores, vea nuestra lista completa de EGFR Anticuerpos.


NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
3-(4-Isopropylbenzylidenyl)­indolin-2-onesc-2024133-(4-Isopropylbenzylidenyl)indolin-2-one is a non-selective inhibitor of rRTKs. It inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R RTKs NÚMERO DE CAS 186611-55-2

Afatinibsc-364398Afatinib (BIBW2992) is an irreversible EGFR/Neu inhibitor in many cancerous cell lines. Afatinib has been shown to prevent angiogenesis. NÚMERO DE CAS 439081-18-2

AG-490sc-202046AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. NÚMERO DE CAS 134036-52-5

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AG 1478 hydrochloridesc-361101AG 1478 hydrochloride is a highly potent EGFR (EGFR-kinase) inhibitor and an antiproliferative agent. NÚMERO DE CAS 153436-53-4

AG 494sc-202043AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM) NÚMERO DE CAS 133550-35-3

AG 555sc-203500AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) NÚMERO DE CAS 133550-34-2

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Src/EGFR inhibitorsc-3050Src/EGFR Inhibitor is a synthetic inhibitor for Src and EGFR. Sequence derived from v-Src 137-157.

AG 825sc-202045AG 825 is an inhibitor of EGFR and HER-2 (Neu) kinases shown to induce apoptosis, prevent colony formation of cells, and interfere with mitogenic signaling. NÚMERO DE CAS 149092-50-2

ARRY334543sc-364410ARRY334543 is a potent, selective inhibitor of EGFR phosphorylation, which blocks signal transduction from the EGFR site. NÚMERO DE CAS 845272-21-1

AST 1306sc-364413AST 1306 is a potent and selective inhibitor of EGFR. This compound blocks EGF-depended phosphorylation of EGFR and inhibits downstream pathways as well. NÚMERO DE CAS 897383-62-9

AZD8931sc-364426AZD8931 is a potent inhibitor of EGFR phosphorylation and subsequent signal transduction. NÚMERO DE CAS 848942-61-0

BIBU 1361 dihydrochloridesc-203844BIBU 1361 dihydrochloride is a selective inhibitor of EGFR-kinase. NÚMERO DE CAS 793726-84-8

BIBX 1382sc-202497BIBX 1382 is a cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR both in cell-free enzymatic reactions and in culture. NÚMERO DE CAS 196612-93-8

JAK3 Inhibidor IVsc-295217JAK3 Inhibitor IV is a potent, selective, and ATP-competitive inhibitor of JAK3 (pIC50 = 7.1). JAK3 Inhibitor IV is a weak inhibitor of JAK1 (pIC50 = 4.4) and EGF-R (pIC50 = 5.6). NÚMERO DE CAS 58753-54-1

JAK3 Inhibidor Vsc-295218JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. NÚMERO DE CAS 4452-06-6

BPDQsc-311299BPDQ is a cell-permeable, reversible, ATP-competitive, potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor(EGFR).

Herbimycin Asc-3516Herbimycin A inhibits c-Abl, Hsp90, c-Src, c-Yes (Yes), Fes (Fps), Ros, and EGFR (ErbB) oncogene products and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C. NÚMERO DE CAS 70563-58-5

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BPIQ-Isc-202507BPIQ-I is a potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50=25 pM). NÚMERO DE CAS 174709-30-9

BPIQ-II HCl Saltsc-221375BPIQ-II HCl Salt is a specific and potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50 = 8 pM).

PKC-412sc-200691PKC-412 has been reported to be an antiproliferatiive agent which inhibits protein kinase C. Additionally PKC-412 has been shown to increase endothelial nitric oxide (NO) synthase expression and NO production. NÚMERO DE CAS 120685-11-2

Canertinibsc-207397Canertinib is a potent and selective inhibitor of EFRG phosphorylation at tyrosine residues. NÚMERO DE CAS 267243-28-7

CGP 74514Asc-391004CGP 74514A is a cell permeable, potent, and selective inhibitor of CDK/cyclin B, PKCα, PKA, and EGFR.

CGP-74514A hydrochloridesc-300344CGP-74514A is a Cdk inhibitor selective for Cyclin-dependent kinase-1 (Cdk1). NÚMERO DE CAS 1173021-98-1

CL-387,785sc-221429CL-387,785 irreversibly inhibits EGF-receptor (EGFR) kinase activity as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR.

SU 5402sc-204308SU 5402 is an FGFR-specific tyrosine kinase inhibitor. Research shows that inhibition of FGFR results in the blocking of NVPs secretion and an increase of Ca2+. NÚMERO DE CAS 215543-92-3

RG-13022sc-200591RG-13022 is a Tyrosine kinase tyrphostin which inhibits the EGFR (EGF receptor) and PDGFR Tyk (tyrosine kinase). It suppresses EGF-stimulated cancer cell proliferation in cancer cell studies. NÚMERO DE CAS 136831-48-6

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CUDC 101sc-364473CUDC 101 is a potent inhibitor of EGFR, HDAC, and HER2, with an IC50 of 2.4 nM, 4.4 nM, and 15.7 nM, respectively. NÚMERO DE CAS 1012054-59-9

CUDC-101sc-364474CUDC-101 is a multi-target HDAC, EGFR, and HER2 inhibitor. NÚMERO DE CAS 1012054-59-9

Dacomitinibsc-364478Dacomitanib is a potent inhibitor of EGFR T710M phosphorylation and induces apoptosis in cancer cell lines expressing this mutation. NÚMERO DE CAS 1110813-31-4

DAPHsc-200698DAPH is an EGFR tyrosine kinase inhibitor, which suppresses and reverses the formation of Aβ42 fibers in neurons. NÚMERO DE CAS 145915-58-8

Daphnetinsc-203022Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. Inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM). NÚMERO DE CAS 486-35-1

Vandetanibsc-220364Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families. Specifically inhibits kinase activity of VEGFR-2 (Flk-1). NÚMERO DE CAS 443913-73-3

Desmethyl Erlotinib Acetatesc-218150Desmethyl Erlotinib Acetate is a demethylated derivative of Erlotinib, which is a potent inhibitor of EGFR. NÚMERO DE CAS 183320-15-2

Didesmethyl Erlotinib Hydrochloride Saltsc-207566Didesmethyl Erlotinib Hydrochloride Salt is a metabolite of Erlotinib, which acts as a potent EGFR inhibitor. NÚMERO DE CAS 183320-12-9

EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibidorsc-221579EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor is a cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human Flg (FGFR-1), PDGFR-β, c-Scr, and EGFR. NÚMERO DE CAS 1135256-66-4

EGFR Inhibidorsc-203934EGFR Inhibitor is a cell permeable compound that is a highly selective inhibitor of EGFR, via downregulation of antiapoptotic protein survivin. NÚMERO DE CAS 879127-07-8

EGFR Inhibidor IIIsc-221580EGFR Inhibitor III is a cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation while having no effect on the expression levels of EGFR

EGFR/ErbB-2 Inhibidorsc-203935EGFR/ErbB-2 Inhibitor is a cell-permeable 4-anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and Neu (c-erbB-2) (IC50 = 20 nM & 79 nM, respectively) NÚMERO DE CAS 179248-61-4

Erbstatin Analogsc-200511Erbstatin Analog is an inhibitor of EGFR (epidermal growth factor receptor)-associated tyrosine kinase. Blocks EGFR-mediated cellular phenotypic changes and delays EGF-induced DNA synthesis. NÚMERO DE CAS 63177-57-1

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ZM 323881 hydrochloridesc-296861ZM 323881 hydrochloride is a potent receptor tyrosine kinase inhibitor of VEGFR-2 (Flk-1), PDGFR-beta, EGFR, and FGFR1 targets. NÚMERO DE CAS 324077-30-7

Erlotinib Hydrochloridesc-202154Erlotinib Hydrochloride is an inhibitor of human epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase, blocking EGFR signaling. NÚMERO DE CAS 183319-69-9

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Erlotinib-d6, Hydrochloride Saltsc-218329Erlontinib-d6 HCl is a potent inhibitor of the autophosphorylation of EGFR.

Gefitinibsc-202166Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor that has been shown to increase phosphorylation of c-Jun NH2 -terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. NÚMERO DE CAS 184475-35-2

1
Gefitinib 2hydrochloride saltsc-337853Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor that has been shown to increase phosphorylation of c-Jun NH2 -terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. NÚMERO DE CAS 184475-56-7

Gefitinib hydrochloride saltsc-337854An epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor that has been shown to increase phosphorylation of c-Jun NH2 -terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. NÚMERO DE CAS 184475-55-6

Gefitinib O-Methyl-D3sc-218566Gefitinib O-Methyl-D3 is an antineoplastic agent that inhibits tyrosine residue phosphorylation in EGFR, which in turn inhibits angiogenesis.

GW 583340 Dihydrochloridesc-224012GW 583340 Dihydrochloride is a potent dual EGFR/ErbB2 inhibitor. NÚMERO DE CAS 388082-81-3

GW2974sc-252869GW2974 is a dual selective inhibitor of EGFR and Neu (ErbB-2) receptor tyrosine kinases. This compound inhibits cancer line PC-3 growth. NÚMERO DE CAS 202272-68-2

HDS 029sc-203995HDS 029 is a potent inhibitor of EGFR and related kinases by inhibiting autophosphorylation of the receptor by the intrinsic tyrosine kinase. NÚMERO DE CAS 881001-19-0

Hypericinsc-3530Hypericin inhibits PKC, Casein Kinase II (CKII), MAP Kinase, Insulin R, EGFR, PI-3 Kinase and also noted to possess antiviral activity. NÚMERO DE CAS 548-04-9

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JNJ 28871063 hydrochloridesc-204025JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor (IC50 values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC50 = 60 - 168 nM). NÚMERO DE CAS 944341-54-2

Lapatinibsc-353658 NÚMERO DE CAS 231277-92-2

Lapatinib Ditosylatesc-202205Lapatinib Ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases. Research studies have reported that the compound can inhibit breast cancer cell proliferation. NÚMERO DE CAS 388082-78-8

Tyrphostin 47 (RG-50864, AG-213)sc-200543Tyrphostin 47 (RG-50864, AG-213) is a protein tyrosine kinase inhibitor particularly potent against EGFR (epidermal growth factor receptor) kinase activity. NÚMERO DE CAS 122520-86-9

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Lapatinib Ditosylatesc-207822Lapatinib Ditosylate is a selective and effective inhibitor of ErbB-2 and EGFR dual tyrosine kinases. Research studies have reported that the compound can inhibit breast cancer cell proliferation. NÚMERO DE CAS 388082-77-7

Lapatinib-13C2,15N Ditosylatesc-280905Lapatinib-13C2,15N Ditosylate is a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.

Lavendustin Asc-200539Lavendustin A selectively and potently inhibits the EGFR tyrosine kinase. The coumpound has been reported to suppress angiogenesis. NÚMERO DE CAS 125697-92-9

Lavendustin Csc-202207Lavendustin C inhibits CaMKII, EGFR tyrosine kinase, crystal-stimulated neutrophil degranulation and SRC. NÚMERO DE CAS 125697-93-0

Lavendustin C methyl estersc-221838Lavendustin C methyl ester is an inhibitor of EGFR tyrosine kinase

LFM-A12sc-295360LFM-A12 is a potent and specific inhibitor of the EGFR tyrosine kinase in vitro. Has been shown to kill over 99% of human breast cancer cells in vitro by triggering apoptosis.

Neratinibsc-364549Neratinib is a potent and selective inhibitor of EGFR and HER2 and is active against a variety of cancerous cell lines. Inhibits phosphorylation of EGFR and HER2 thus preventing signal cascade. NÚMERO DE CAS 698387-09-6

O-Desmethyl Gefitinibsc-212448O-Desmethyl Gefitinib is a major metabolite of Gefitinib, which is a potent inhibitor of tyrosine residue phosphorylation in EGFR. NÚMERO DE CAS 847949-49-9

WHI-P 154sc-204395WHI-P 154 is a JAK3 inhibitor (IC50 = 1.8 μM). WHI-P 154 inhibits other common kinases including EGFR (IC50 = 4 nM), SRC, c-Abl, VEGFR, MAPK and PI 3-kinase. NÚMERO DE CAS 211555-04-3

O-Desmorpholinopropyl Gefitinibsc-212456O-Desmorpholinopropyl Gefitinib is a metabolite of Gefitinib, which is a potent inhibitor of tyrosine residue phosphorylation in EGFR NÚMERO DE CAS 184475-71-6

OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)sc-219500OSI-420-d4 is a labeled metabolite of Erlotinib, which is a potent autophosphorylation inhibitor of EGFR.

OSI-420, Free Base (Desmethyl Erlotinib)sc-212485OSI-420 is a metabolite of Erlontinib, which is a potent autophosphorylation inhibitor of EGFR. NÚMERO DE CAS 183321-86-0

PD 153035sc-205909PD 153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of the EGFR (epidermal growth factor receptor). NÚMERO DE CAS 153436-54-5 (HCl salt)

PD 153035 Hydrochloridesc-205963PD 153035 Hydrochloride is an extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase NÚMERO DE CAS 153436-54-5

PD 158780 solutionsc-202758PD 158780 solution contains a potent tyrosine kinase inhibitor that can permeate cells and shows no inhibition against FGF or PDGF-mediated tyrosine phosphorylation. NÚMERO DE CAS 171179-06-9

PD 168393sc-222138PD 168393 is a potent, irreversible, cell-permeable and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity.

PD 174265sc-204170PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR (EGF receptor) tyrosine kinase activity (IC50 = 450 pM). NÚMERO DE CAS 216163-53-0

Pelitinibsc-208155Pelitinib binds to EGFR, inhibiting receptor phosphorylation and thus stopping signal transduction. NÚMERO DE CAS 257933-82-7

PP 3sc-203213PP 3 is an inhibitor of EGFR tyrosine kinase, blocking autophosphorylation of the receptor. NÚMERO DE CAS 5334-30-5

RO 106-9920sc-203240RO 106-9920 acts as a highly selective, irreversible inhibitor of IkBaee ubiquitination. At 10 μM concentrations, this compound also inhibits the activities of 5-LO (5-lipoxygenase) and EGFR kinase. NÚMERO DE CAS 62645-28-7

(+)­-Aeroplysinin-1sc-202445(+)-Aeroplysinin-1 displays cytostatic and cytotoxic activity. Inhibitor of EGFR (EGFR kinase). Shows antiangiogenic activity. NÚMERO DE CAS 28656-91-9

TAK 165sc-361372TAK 165 is a potent EGFR and p34cdc2 inhibitor that exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines. NÚMERO DE CAS 366017-09-6

TAK 285sc-364627TAK 285 is a potent and selective inhibitor of EGFR phosphorylation. TAK 285 displays similar in vitro potency against EGFR and HER2. NÚMERO DE CAS 871026-44-7

Tyrphostin 47sc-216031Tyrphostin 47 inhibits EGFR tyrosine kinase activity NÚMERO DE CAS 118409-60-2

Tyrphostin 51sc-200545Tyrphostin 51 is a potent inhibitor of EGFR kinase activity. Inhibition is mixed competitive with ATP and substrate. NÚMERO DE CAS 122520-90-5

Tyrphostin AG 1478sc-200613Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR; reported to block EGF-dependent src-family kinase activation and ERK phosphorylation. NÚMERO DE CAS 175178-82-2

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Tyrphostin AG 183sc-202846Tyrphostin AG 183 is a potent inhibitor of EGFR tyrosine kinase NÚMERO DE CAS 126433-07-6

Tyrphostin AG 528sc-216034Tyrphostin inhibits EGFR autophosphorylation, blocking signal transuduction. NÚMERO DE CAS 133550-49-9

Tyrphostin AG 99sc-202847Tyrphostin AG 99 is a potent, cell-permeable, reversible inhibitor of epidermal growth factor receptor (EGFR) and EGF-dependent cell proliferation. NÚMERO DE CAS 118409-59-9

Tyrphostin B44, (-) enantiomersc-203711Tyrphostin B44, (-) enantiomer is a potent and selective inhibitor of EGFR tyrosine kinase activity NÚMERO DE CAS 133550-32-0

Tyrphostin B44, (+) enantiomersc-203305Tyrphostin B44(+) is an inhibitor of EGFR tyrosine kinase, which blocks autophosphorylation of the receptor, stopping signal transduction from the receptor. NÚMERO DE CAS 133550-37-5

Tyrphostin RG 14620sc-200593Tyrphostin RG 14620 is a non-phenolic tyrphostin analog, which is selective for the EGFR (EGF receptor). Inhibits EGF-stimulated HER14 cell proliferation as well as tumor growth in vivo. NÚMERO DE CAS 136831-49-7

WZ 3146sc-364654WZ 3146 is a potent and selective inhibitor of several mutatant EGFR. WZ 3146 inhibits phosphorylation of EGFR mutants and induces apoptosis. NÚMERO DE CAS 1214265-56-1

WZ 4002sc-364655WZ 4002 is a potent and selective EGFR inhibitor that blocks signal transduction at the cell surface, leading to apoptosis. NÚMERO DE CAS 1213269-23-8

WZ8040sc-364656WZ8040 is an irreversible inhibitor of EGFR T790M which is detected in 50% of cell lines resistant to quinazoline-based EGFR inhibitors NÚMERO DE CAS 1214265-57-2

XL647sc-364659XL657 is an extremely potent inhibitor of EGFR phosphorylation, which blocks signal transduction. NÚMERO DE CAS 651031-01-5

Buteinsc-202510Butein is a plant polyphenol which acts as a specific protein tyrosine kinase inhibitor which potently inhibits the EGF receptor. Also inhibits IKK, GST, CYP19, and glutathione reductase. NÚMERO DE CAS 487-52-5

PD 161570sc-361284PD 161570 is a selective FGFR inhibitor. PD 161570 inhibits FGFR receptor phosphorylation and growth of A121 cells in vitro. NÚMERO DE CAS 192705-80-9

RET Receptor Tyrosine Kinase Inhibidorsc-222249RET Receptor Tyrosine Kinase Inhibitor is a cell-permeable ATP-competitive tyrosine kinase inhibitor that is known to target Ret, EGFR, and Met.

Tyrphostin AG 112sc-222381 NÚMERO DE CAS 144978-82-5

Vatalanib Dihydrochloridesc-202379Vandetanib dihydrochloride inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation by preventing the autophosphorylation of these receptors. NÚMERO DE CAS 212141-51-0