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Calpain Inhibidores

We now offer a broad range of Calpain Inhibitors. Calpains are a family of cytosolic calcium-regulated cysteine proteases that functions to regulate a wide variety of cellular processes. Calpain cleaves cytoskeletal and submembranous proteins, and is thought to play a role in cytoskeletal reorganization and muscle protein degradation. Calpain Inhibitors offered by Santa Cruz inhibit Calpain and, in some cases, other cell cycle and cytoskeletal related proteins. View detailed Calpain Inhibitor specifications, including Calpain Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by linking to the specific product blocks.

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Para el análisis funcional de losCalpain Inhibidores, vea nuestra lista completa de Calpain Anticuerpos.


NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
Aclacinomycin A (Aclarubicin)sc-200160Aclacinomycin A is the first described non-peptidic inhibitor showing discrete specificity for the CTRL activity. It stimulates trypsin activity but inhibits the activity of both CTRL and calpain. NÚMERO DE CAS 57576-44-0

1
Penicillidesc-391044Penicillide is an ACAT (acyl-CoA-cholesterol acyltransferase), Calpain, and Oxytocin Receptor inhibitor. NÚMERO DE CAS 55303-92-9

ALLM (Calpain Inhibidor)sc-201268ALLM is a cell-permeable peptide aldehyde inhibitor of calpain and other neutral cysteine proteases. ALLM is a potent inhibitor of cathepsin L (Ki = 0.6 nM) and cathepsin B (Ki = 100nM). NÚMERO DE CAS 136632-32-1

9
ALLNsc-221236ALLN is an inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. It inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. NÚMERO DE CAS 110044-82-1

Calpain Inhibidor Isc-29119Calpain Inhibitor I is an inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. It inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells. NÚMERO DE CAS 110044-82-1

Calpain Inhibidor VIsc-293979Calpain Inhibitor VI is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor. It strongly inhibits cathepsin B and cathepsin L. NÚMERO DE CAS 190274-53-4

ALLN (péptido)sc-3089ALLN (peptide) is a synthetic inhibitor of calpain. It inhibits Ub-dependent proteolysis of IκB by the Ub-proteasome pathway. It is a cell cycle inhibitor.

1
Calpain Inhibidor XIIsc-300318Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1. It has been shown to inhibit calpain-2 and human cathepsin B only at higher concentrations.

Calpeptinsc-202516Calpeptin is an inhibitor of calpain-2, PLC-β cleavage, cathepsin L, and calpain-1. NÚMERO DE CAS 117591-20-5

1
E-64-csc-201278E-64-c is an effective synthetic calpain inhibitor composed from E-64 (sc-201276), which also inhibits cathepsin B, cathepsin H, and cathepsin L (cysteine proteases). NÚMERO DE CAS 76684-89-4

1
E-64-dsc-201280E-64-d acts as a potent inhibitor of thiol protease. The compound can permeate an intact cell and block the activity of calpain and is a cathepsin B, cathepsin H, and cathepsin L inhibitor. NÚMERO DE CAS 88321-09-9

1
Leupeptin hemisulfatesc-295358Leupeptin hemisulfate is a reversible competitive protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain and trypsin. NÚMERO DE CAS 103476-89-7

E-64sc-201276E-64 is a broad spectrum cysteine proteinase and calpain activation inhibitor. The compound has been reported to inhibit intracellular cathepsin B, Bax protease activity, and reduces oxidative stress. NÚMERO DE CAS 66701-25-5

9
MDL-28170sc-201301MDL-28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease, and an inhibitor of cathepsin B. NÚMERO DE CAS 88191-84-8

7
MG-132 [Z-Leu-Leu-Leu-CHO]sc-201270MG-132 [Z-Leu-Leu-Leu-CHO] is a potent, reversible and selective proteasome inhibitor. It has also been shown to inhibit the activity of NF κB and calpain. NÚMERO DE CAS 133407-82-6

2
PD 145305sc-222131PD 145305 is a useful negative control for the calpain inhibitors PD 150606 (sc-222133) and PD 151746. NÚMERO DE CAS 90536-15-5

PD 150606sc-222133PD 150606 is a cell-permeable, non-competitive, selective, non-peptide calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain. NÚMERO DE CAS 659-22-3

PD 151746sc-222134D 151746 is a cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the Ca2+ binding sites of calpain. It has also been shown to prevent cycloheximide-induced apoptosis.

PGP-4008sc-222152This is a selective P-glycoprotein (Pgp) inhibitor. It effectively reverses Pgp mediated drug resistance in NCI/ADR cells, but has no effect on the drug sensitivities of MCF-7/VP cells that overexpress MRP1. NÚMERO DE CAS 365565-02-2

γ-Secretase Inhibidor IIsc-302013γ-Secretase Inhibitor II is a cell-permeable, reversible inhibitor of γ-secretase. It is also an inhibitor of caalpain.

EDTA, Tetrasodium Salt, Ultra Puresc-391059EDTA, Tetrasodium Salt, Ultra Pure is a chelating agent with wide ranging ability to sequester various polyvalent cations. NÚMERO DE CAS 13235-36-4 (anhydrous)

EDTA, Tetrasodium Tetrahydrate Saltsc-204735EDTA, Tetrasodium Tetrahydrate Salt is a chelating agent with wide ranging ability to sequester various polyvalent cations. NÚMERO DE CAS 13235-36-4

1
Z-L-Abu-CONH-ethylsc-301995Z-L-Abu-CONH-ethyl is a cell-permeable dipeptidyl α-ketoamide that acts as a potent, reversible, and active site inhibitor of calpain-1 and calpain-2 (Ki ~ 250 nM).

Z-L-Abu-CONH(CH2)3-morpholinesc-301996Z-L-Abu-CONH(CH2)3-morpholine is a cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of Calpain 1 and Calpain 2. NÚMERO DE CAS 145731-49-3