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Calcium Channel Modulators

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NOMBRE DEL PRODUCTO NÚMERO DE CATÁLOGODESCRIPCIÓNMENCIONESCLASIFICACIÓN
Amiloride • HClsc-3578Amiloride • HCl is a selective T-type calcium channel protein inhibitor and epithelial sodium channel protein inhibitor. NÚMERO DE CAS 2016-88-8

3
1-D-3-Deoxy-phosphatidylinositolsc-216117A putative antimetabolite of phosphatidylinositol-3-phospate that has been shown to act as a strong agonist in releasing calcium from saponin permeabilized SH-Sy5Y human neuroblastoma cells.

8-Bromo-cADP-Ribose (8-Br-cADPR)sc-2015148-Bromo-cADP-Ribose (8-Br-cADPR) is a cADPR antagonist which prevents the cADPR inducing effects on Ca2+ release from the endoplasmic and sarcoplasmic reticulum. NÚMERO DE CAS 151898-26-9

8
Amlodipinesc-200195Amlodipine is a long-acting dihydropyridine, L-type, calcium channel protein inhibitor and blocker. NÚMERO DE CAS 88150-42-9

2',4'-Dichlorobenzamil • HClsc-200197An inhibitor of Na+/Ca2+ exchanger protein (NCX). Inhibits whole-cell inward currents stimulated by 8-Br-cGMP at nucleotide-gated cation channels. Blocks caffeine-induced release of Ca2+ internal stores from olfactory neurons. NÚMERO DE CAS 1166-01-4

6
Amlodipine besylatesc-203511Amlodipine besylate is an L-type calcium channel protein inhibitor and blocker that contains antihypertensive properties. NÚMERO DE CAS 111470-99-6

1
6-Benzylaminopurinesc-202428Plant cell division factor. Stimulates Ca2+ influx by moss protoplasts. Reportedly induces positive inotropic effects through activation of P2-purinergic receptors. NÚMERO DE CAS 1214-39-7

Azelnidipinesc-252395Azelnidipine is a novel dihydropyridine derivative, an L-type calcium channel protein inhibitor and an antihypertensive. NÚMERO DE CAS 123524-52-7

Bepridil hydrochloridesc-202974Bepridil hydrochloride is a calcium channel protein inhibitor and antagonist that increases the surface area of red blood cells. NÚMERO DE CAS 74764-40-2

Heparin, Sodium Saltsc-203075Heparin, Sodium salt is a low molecular weight heparin (LMWH) polymer that produces its major anticoagulant effect by activating antithrombin NÚMERO DE CAS 9041-08-1

2
9,21-Dehydroryanodinesc-291770A naturally occuring Ryanodine derivative that is shown to influence Ca2+ channels similar to Ryanodine. NÚMERO DE CAS 94513-55-0

A 582941sc-362706A 582941 is a selective AChR α7 partial agonist. It displays ~15-fold selectivity for α7 over 5-HT3 receptors NÚMERO DE CAS 848591-90-2

Cilnidipinesc-201485Cilnidipine is a dual L-/N-type calcium channel protein inhibitor and blocker. NÚMERO DE CAS 132203-70-4

Adenosine 5'-[γ-thio]triphosphate tetralithium saltsc-214500A P2 purinergic agonist that has been shown to substitute for ATP as a kinase substrate, resulting in the formation of phospatase resistant thiophosphorlyated proteins. NÚMERO DE CAS 93839-89-5

Cinnarizinesc-211095Cinnarizine is a calcium channel protein inhibitor. NÚMERO DE CAS 298-57-7

Agitoxinsc-3582Potent inhibitor of the Shaker K+ channel as well as the mammalian homolog of Shaker. Binds to the pore entryway between the subunits of the channel. NÚMERO DE CAS 78207-24-6

Dantrolene, Sodium Saltsc-202124Dantrolene is a small molecule inhibitor of the Ryanodine receptor and a calcium channel protein inhibitor (see Ryanodine, sc-201523). NÚMERO DE CAS 14663-23-1

8
Diltiazem • HClsc-200199Diltiazem HCl is an antihypertensive and cardioprotective agent as well as a calcium channel protein inhibitor. NÚMERO DE CAS 33286-22-5

Amiodarone Hydrochloridesc-291891Shown to inhibit binding of 1,4-dihydropyridine to L-type Ca2+ channels, a/b-adrenergic receptor antagonist, and coronary vasodilator. NÚMERO DE CAS 19774-82-4

Dotarizinesc-203033Dotarizine is a broad spectrum Ca2+ antagonist and calcium channel protein inhibitor which blocks calcium uptake, [Ca2+]i rise and secretion via blockade of calcium channels. NÚMERO DE CAS 84625-59-2

2
Propafenone Hydrochloridesc-204863Propafenone Hydrochloride is a sodium channel protein inhibitor. NÚMERO DE CAS 34183-22-7

(±)-Bay K 8644sc-203324(±)-Bay K 8644 is a synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration. NÚMERO DE CAS 71145-03-4

Efonidipine hydrochloridesc-294464Efonidipine hydrochloride is a calcium channel protein inhibitor. NÚMERO DE CAS 111011-53-1

R 568 hydrochloridesc-361302R 568 hydrochloride is an activator and allosteric agonist of the CaSR (calcium-sensing receptor) via positive allosteric modulation. NÚMERO DE CAS 177172-49-5

BAY K 8644, S(-)-sc-203525A racemic mixture of Bay K 8644 that is shown to be an L-type Ca2+ channel agonist. Also shown to cause an increase in myosin light chain phosphorylation. NÚMERO DE CAS 98625-26-4

Felodipinesc-201483Felodipine is a 1,4-dihydropyridine small molecule antagonist and calcium channel protein inhibitor. NÚMERO DE CAS 72509-76-3

BAY K8644 (+)sc-201506An analogue of nifedipine (sc-3589) that acts as a calcium ion channel agonist displaying positive inotropic activity by inducing Ca2+-dependent slow action potentials, enhancing the influx of Ca2+ into sarcolemma through myocardial slow channels. NÚMERO DE CAS 98791-67-4

7
Flunarizine • 2HClsc-201473Flunarizine • 2HCl, a calcium channel protein inhibitor and antagonist, has been shown to inhibit contraction of isolated murine caudal artery preparations. NÚMERO DE CAS 30484-77-6

Caged Ca2+ channel antagonistsc-227563 NÚMERO DE CAS 154026-67-2

HA-1077 dihydrochloridesc-200583HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2, cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. NÚMERO DE CAS 103745-39-7

Calcicludine IIsc-293976Potent neurotoxin shown to preferentially block type L Ca2+ channels. NÚMERO DE CAS 178037-96-2

Isradipinesc-201467Isradipine is a 2,4-dihydropyridine selective agonist and calcium channel protein inhibitor. NÚMERO DE CAS 75695-93-1

Calcitonin, Salmonsc-201167Calcitonin, Salmon is a calcium-regulating peptide hormone released from the thyroid, containing 32 amino-acid residues, showing hypocalcaemic and hypophosphatemic action. NÚMERO DE CAS 47931-85-1

L-651,582sc-204039L-651,582 is a calcium channel protein inhibitor. NÚMERO DE CAS 99519-84-3

L-cis-Diltiazem • HClsc-221802L-cis-Diltiazem • HCl is a cyclic nucleotide-gated calcium channel protein inhibitor. NÚMERO DE CAS 42399-54-2

CAY10502sc-223866A potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with an IC50 value of 4.3 nM for the purified enzyme from human platelets. Inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.

L-Type Calcium Channel Blockersc-221814L-Type Calcium Channel Blocker is a calcium channel protein inhibitor.

Lanthanum(III) chloride heptahydratesc-211720Lanthanum(III) chloride heptahydrate is a calcium channel protein inhibitor. NÚMERO DE CAS 10025-84-0

Dantrolene, Sodium Salt Hemiheptahydratesc-218075A muscle relaxant (skeletal). Used in the treatment of malignant hyperthermia. NÚMERO DE CAS 24868-20-0

Lercanidipine hydrochloridesc-204054Lercanidipine hydrochloride is a calcium channel protein inhibitor. NÚMERO DE CAS 132866-11-6

DHBP dibromidesc-203564Blocks calcium release from sarcoplasmic reticulum by direct interaction with the ryanodine receptor. NÚMERO DE CAS 6159-05-3

Lercanidipine hydrochloride hemihydratesc-252951Lercanidipine hydrochloride hemihydrate is a calcium channel protein inhibitor. NÚMERO DE CAS 132866-11-6 (anhydrous)

Lercanidipine-d3 (hydrochloride)sc-221841Lercanidipine-d3 (hydrochloride) is a calcium channel protein inhibitor.

CGP 37157sc-202097CGP 37157 is a benzothiazepine compound that is derived from clonazepam and described to act as a selective and potent inhibitor of mitochondrial Na+/Ca2+ exchange. NÚMERO DE CAS 75450-34-9

1
Diethyl Pyrocarbonatesc-202574Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle, and could be useful for specific inactivation of nucleases. NÚMERO DE CAS 1609-47-8

1
Lomerizine Hydrochloridesc-204795Lomerizine Hydrochloride is a calcium channel protein inhibitor. NÚMERO DE CAS 101477-54-7

Diltiazemsc-204726Potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. Its pharmacological activity is somewhat similar to verapamil. NÚMERO DE CAS 42399-41-7

Loperamide Hydrochloridesc-203116Loperamide (Hydrochloride) is an opiate agonist and a calcium channel protein inhibitor. Loperamide (Hydrochloride) is a specific μ-opiod receptor (MOR) agonist. NÚMERO DE CAS 34552-83-5

Manidipinesc-211774Manidipine is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. NÚMERO DE CAS 89226-50-6

Manidipine dihydrochloridesc-205739Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. NÚMERO DE CAS 89226-75-5

(+)-Egeninesc-203038First phthalideisoquinoline hemiacetal from a natural source. Inhibits Ca2+ currents and contractile responses in vitro. NÚMERO DE CAS 6883-44-9

(±)-Methoxyverapamil Hydrochloridesc-202706(±)-Methoxyverapamil Hydrochloride is a selective calcium channel protein inhibitor. NÚMERO DE CAS 16662-47-8

Fasudil, Monohydrochloride Saltsc-203418Fasudil monohydrochloride is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. NÚMERO DE CAS 105628-07-7

Mibefradil dihydrochloridesc-204083Mibefradil dihydrochloride is a nondihydropyridine antagonist and calcium channel protein inhibitor which selectively blocks Ca2+ entry into cells. NÚMERO DE CAS 116644-53-2

MRS 1845sc-203636MRS 1845 is a potent calcium channel protein inhibitor and inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). NÚMERO DE CAS 544478-19-5

Fendiline hydrochloridesc-239988A coronary vasodilator. NÚMERO DE CAS 13636-18-5

SKF-525A HCl (Proadifen)sc-200492SKF-525A HCl (Proadifen) has inhibitory effects on NOS1, AChR, the CYP (cytochrome P450) system, arachidonate metabolism, transmembrane calcium influx, platelet thromboxane synthesis, and KIR6.1. NÚMERO DE CAS 62-68-0

Nemadipine-Asc-202727Nemadipine-A is a cell permeable L-type calcium channel protein inhibitor in C. elegans and vertebrates. NÚMERO DE CAS 54280-71-6

FPL-64176sc-201491A potent L-type Ca2+ channel opener. Induces a contractile response in cardiac and vascular smooth muscle, EC50=0.2 µM. NÚMERO DE CAS 120934-96-5

Nemadipine-Bsc-203157Nemadipine-A is a cell permeable L-type calcium channel protein inhibitor in C. elegans. NÚMERO DE CAS 79925-38-5

Gabapentinsc-201481Gabapentin is a structurally similar GABA (γ-aminobutyric acid) analog which binds to a novel site on voltage-sensitive Ca2+ channels. NÚMERO DE CAS 60142-96-3

Nicardipine hydrochloridesc-202731Nicardipine hydrochloride is the hydrochloride salt preparation of Nicardipine and a potent L-type calcium channel protein inhibitor. NÚMERO DE CAS 54527-84-3

Nifedipinesc-3589Nifedipine is a selective hypertensive calcium channel protein inhibitor which targets L-type voltage-sensitive calcium channels. NÚMERO DE CAS 21829-25-4

11
Heparin, Lithium Salt, Porcine Intestinal Mucosasc-203997Highly sulfated dextrorotatory mucopolysaccharide with specific anticoagulant properties. Inhibits the endoplasmic reticulum IP3-activated Ca2+ release channel. Reported to also activate the ryanodine receptor. Note: 1 KU = 1000 units. Preservative-free, non-sterile. NÚMERO DE CAS 9045-22-1

Nimodipinesc-201464Nimodipine is an L-type calcium channel protein inhibitor. NÚMERO DE CAS 66085-59-4

Hepoxilin A3sc-221713An eicosanoid, which functions as an endogenous lipid mediator, inducing the release of intracellular calcium in human neutrophils. NÚMERO DE CAS 85589-24-8

Nitrendipinesc-201466Nitrendipine is a dihydropyridine-type voltage-sensitive (L-type) calcium channel protein inhibitor and blocker. NÚMERO DE CAS 39562-70-4

2
Iberiotoxinsc-3585A highly selective and potent blocker of the high conductance Ca2+-activated K+ channels that does not affect other types of voltage-dependent K+ channels. NÚMERO DE CAS 129203-60-7

10
NNC 55-0396sc-203647NNC 55-0396 is a nonhydrolyzable analog of Mibefradil dihydrochloride (sc-204083) which functions as a selective T-type calcium channel protein inhibitor. NÚMERO DE CAS 357400-13-6

NNC 55-0396 hydratesc-301481NNC 55-0396 hydrate is a calcium channel protein inhibitor. NÚMERO DE CAS 357400-13-6

Ionomycin free acidsc-263405An antibiotic selective calcium ionophore, which can extract calcium ions from aqueous phase to organic phase. Can transport other ions such as Mg, Sr, and Ba with a weaker affinity. NÚMERO DE CAS 56092-81-0

PD 173212sc-204169PD 173212 is an N-type voltage-gated calcium channel protein inhibitor. PD 173212 is selective of K+, Na+, and L-type Ca2+ channels. NÚMERO DE CAS 217171-01-2

Kurtoxinsc-300858Kurtoxin is a compound found in scorpion toxin, and is a T-type Ca2+ channel blocker.

Protopine hydrochloridesc-272121Protopine hydrochloride is a light-sensitive calcium channel protein inhibitor and antiplatelet agent. NÚMERO DE CAS 6164-47-2

LOE 908 hydrochloridesc-204060Broad spectrum cation channel blocker; neuroprotective NÚMERO DE CAS 149759-26-2

Midodrine, Hydrochloridesc-211910A phenylalkanolamine derivative which has been found to be effective in the treatment of hypertensive conditions due to their long lasting, blood pressure increasing effects. NÚMERO DE CAS 3092-17-9

myo-Inositol 1,3,4,6-tetrakis-phosphate ammonium saltsc-215403An inositol tetrakisphosphate described to accumulate in angiotensin II-stimulated cells. Demonstrated to stimulate the mobilization of intracellular Ca2+ in SH-SY5Y cells. NÚMERO DE CAS 142507-74-2

Ruthenium redsc-202328Ruthenium red is a calcium channel protein inhibitor. Ruthenium red also blocks cell membrane-located capsaicin-activated cation channels NÚMERO DE CAS 11103-72-3

5
N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamidesc-295632N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. This chemical is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM). It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors. This compound is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion. NÚMERO DE CAS 457897-92-6

SK&F 96365sc-201475SK&F 96365 is a calcium channel protein inhibitor that has been shown to specifically inhibit Stim 1 and voltage-gated Ca2+ channels. NÚMERO DE CAS 130495-35-1

Nicotinic acid adenine dinucleotide phosphate sodium saltsc-215564Potent activator of intracellular Ca2+ release by a cyclic ADP ribose-independent and IP3 mechanism. NÚMERO DE CAS 5502-96-5

SR 33805 oxalatesc-204299SR 33805 oxalate is a potent calcium channel protein inhibitor. NÚMERO DE CAS 121346-32-5

Niguldipine • HClsc-201471A highly selective α 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker. Also been noted to inhibit noradrenaline-stimulated inositol phosphate accumulation. NÚMERO DE CAS 113317-61-6

KB-R7943 MESYLATEsc-202681KB-R7943 mesylate is a cell permeable, potent, selective NCKX inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. NÚMERO DE CAS 182004-65-5

1
Tetrandrinesc-201492Tetrandrine is a calcium channel protein inhibitor. NÚMERO DE CAS 518-34-3

Pamidronate, Disodium Saltsc-203178A bisphosphonate calcium metabolism regulator which specifically induces calcium reabsorption in bones. NÚMERO DE CAS 109552-15-0

trans Lacidipinesc-213066trans Lacidipine is a dihydropyridine calcium channel protein inhibitor and blocker. NÚMERO DE CAS 103890-78-4

Verapamilsc-3590Verapamil is an α-adrenergic antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. NÚMERO DE CAS 152-11-4

11
Penfluridolsc-255410A T-type Ca2+ channel blocker and antipsychotic. NÚMERO DE CAS 26864-56-2

Pranidipinesc-212579A novel calcium channel antagonist as well as a cardiovascular agent. NÚMERO DE CAS 99522-79-9

Pyr3 sc-301624A pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy. Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy. NÚMERO DE CAS 1160514-60-2

(R)-(+)-Felodipinesc-212658Enantiomer NÚMERO DE CAS 119945-59-4

Ru360sc-222265An oxygen-bridged dinuclear ruthenium amine complex that has been noted to selectively and potently inhibit mitochondrial calcium uptake without affecting other calcium channels.

(S)-(-)-Felodipinesc-212833Enantiomer NÚMERO DE CAS 105618-03-9

SDZ-202 791 R(-)sc-201474A dihydropyridine-type voltage-sensitive (L-type) calcium channel blocker. NÚMERO DE CAS 97217-84-0

Stellettamide A trifluoroacetatesc-202819Inhibits intrinsic tyrosine fluorescence in a concentration-dependent manner. Binds to calmodulin and inhibits 2+//calmodulin-dependent enzyme activities. NÚMERO DE CAS 129744-24-7

TCS 5861528sc-361378TCS 5861528 is a TRPA1 channel blocker and an antagonizer of AITC- and 4-HNE-evoked calcium influx. NÚMERO DE CAS 332117-28-9

Tetrahydropalmatine hydrochloridesc-296504Voltage-dependent Ca2+ channel inhibitor. NÚMERO DE CAS 6024-85-7

Thionicotinamide adenine dinucleotidephosphate sodium saltsc-253695Blocks nicotinate adenine dinucleotide phosphate (NAADP)-induced Ca2+ release. NÚMERO DE CAS 19254-05-8

trans-Ned 19sc-362814 NÚMERO DE CAS 1354235-96-3

Verapamil Ethyl Methanethiosulfonate, Bromidesc-208483An analog of Verapamil. NÚMERO DE CAS 353270-25-4

w-Grammotoxin SIAsc-251432A potent inhibitor of Cav2.1 (P-type) and Cav2.2 (N-type) channels. NÚMERO DE CAS 152617-90-8

ω-Agatoxin TKsc-200190ω-Agatoxin TK is a selective blocker of the P-type Ca2+ channel. NÚMERO DE CAS 158484-42-5

Xestospongin D, Xestospongia sp.sc-222422Xestospongin D, Xestospongia sp. is a reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM).

Ziconotide Acetatesc-213176A selective antagonist of N-type voltage sensitive calcium channels (VSCC). It blocks neurotransmitter release by preventing depolarization-induced calcium influx. It is also used as a ligand for binding studies of voltage sensitive calcium channels.

RP 67580sc-204894RP 67580 is a potent and selective tachykinin NK1 receptor antagonist. Displays higher affinity at rat and mouse than human receptors. NÚMERO DE CAS 135911-02-3

Neuropeptide Ysc-3140Neuropeptide Y is a biologically active peptide. A synthetic potassium channel blocker. A potent vasoconstrictor. Reversibly inhibits Ca2+-activated K+ channels in vascular smooth muscle cells.

Repaglinidesc-219959Repaglinide is a KIR6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with KIR6.2(Kd = 0.42 nM). NÚMERO DE CAS 135062-02-1

SN-6sc-203698SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor that displays some selectivity for NCX1. This compound is also a potential anti-ischemic. NÚMERO DE CAS 415697-08-4

PSTAIRE péptidosc-3142PSTAIRE peptide is a synthetic peptide with epitope mapping within an internal region of interleukin-11 of human origin. This peptide is useful for micro-injection studies.

1,2-benzoxazol-3-ylmethanesulfonamidesc-3391841,2-benzoxazol-3-ylmethanesulfonamide (Zonisamide) is an anticonvulsant blocker of voltage-sensitive T-type Ca2+ and Na+ channels. NÚMERO DE CAS 68291-97-4

Naphtho[1,2-d]thiazol-2-ylaminesc-279906Naphtho[1,2-d]thiazol-2-ylamine is an activator of Ik1, SK1 and KCNN2. NÚMERO DE CAS 40172-65-4