Angiogenesis Inhibidores

Presentamos HOVERcruz™,

¡Chat en linea está disponible! (haga click aquí)

NOMBRE DEL PRODUCTO	NÚMERO DE CATÁLOGO	DESCRIPCIÓN	MENCIONES	CLASIFICACIÓN
Streptochlorin	sc-391103	NÚMERO DE CAS 120191-51-7
2-Methoxyestradiol	sc-201371	2-Methoxyestradiol is an HIF-1 inhibitor of mediated transcriptional activation of target genes without affecting the transcription of HIF-1α itself and also disrupts microtubule function. NÚMERO DE CAS 362-07-2	3
AAL-993	sc-221195	AAL-993 is a highly potent inhibitor of Flt-1 (VEGFR-1), Flk-1 (VEGFR-2) and Flt-4 (VEGFR-3). AAL-993 is cell permeable, and inhibits VEGF-induced angiogenesis in a mouse model. NÚMERO DE CAS 269390-77-4
3,5,4'-Trimethoxystilbene	sc-201450	An antiangiogenic agent and permethylated derivative of Resveratrol (sc-200808) that has been shown to inhibit endothelial cell proliferation, cause microtubule disassembly and tubulin depolymerization. NÚMERO DE CAS 22255-22-7
17-DMAG	sc-202005	17-DMAG is a synthetic derivative of Geldanamycin with lower hepatotoxicity. 17-DMAG inhibits Hsp90, a cellular chaperone that participates in folding of proteins found in multiple signal transduction pathways. NÚMERO DE CAS 467214-20-6	4
Cochlioquinone A	sc-202109	Major component of a bioactive pigment isolated from Bipolaris leersia. It has been found to be an antagonist of the human chemokine receptor CCR5 in HIV-1. Anti-angiogenic. NÚMERO DE CAS 32450-25-2
4-Hydroxyphenylretinamide	sc-200900	A synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. NÚMERO DE CAS 65646-68-6
Cochlioquinone B	sc-202110	The minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH ubiquinonereductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A. NÚMERO DE CAS 32450-26-3
Imiquimod	sc-200385	Imiquimod is a TLR7 (toll-like receptor 7) activator. Inhibits angiogenesis, induces apoptosis and modifies the immune response. Suggested to activate caspase-3 and NFκB. NÚMERO DE CAS 99011-02-6
H-Gly-Pro-Arg-Pro-OH Acetate Salt	sc-203071	The inhibitor can bind to the polymerization site (D domain) in fibrinogen (Ki = 400 mM) and prevent fibrinogen aggregation and fibrin polymerization. NÚMERO DE CAS 67869-62-9	1
Borrelidin	sc-200379	Borrelidin is an anti-angiogenic and anti-microbial compound that disrupts capillary tube formation by activating caspase-3 and caspase-8. It also inhibits ThrRS and HUVEC proliferation. NÚMERO DE CAS 7184-60-3
Irsogladine maleate	sc-201190	Irsogladine maleate is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding. NÚMERO DE CAS 84504-69-8
KI 8751	sc-203090	KI 8751 is a selective inhibitor of Flk-1 (VEGFR-2) and c-Kit that has been shown to decrease cell proliferation and tumor growth. NÚMERO DE CAS 228559-41-9
Mifepristone	sc-203134	Reported to be an antioxidant and antiangiogenic compound. Also found to demonstrate the ability to suppress activation of NFκB. NÚMERO DE CAS 84371-65-3	6
Terbinafine·HCl	sc-200751	Terbinafine·HCl is a potent squalene epoxidase inhibitor and, as a result, a suppressor of ergosterol biosynthesis. Also reported as a free radical scavenger as well as an anti-angiogenic agent. NÚMERO DE CAS 78628-80-5
Herbimycin A	sc-3516	Herbimycin A inhibits c-Abl, Hsp90, c-Src, c-Yes (Yes), Fes (Fps), Ros, and EGFR (ErbB) oncogene products and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C. NÚMERO DE CAS 70563-58-5	8
Minocycline, Hydrochloride	sc-203339	Minocycline hydrochloride displays anticollagenase, antimicrobial, and anti-inflammatory properties. Reported to inhibit the enzymatic activity of PARP and angiogenesis. NÚMERO DE CAS 13614-98-7	5
Cytochalasin E, Aspergillus clavatus	sc-202561	Cytochalasin E, Aspergillus clavatus is fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. NÚMERO DE CAS 36011-19-5	4
OGT 2115	sc-204144	OGT 2115 inhibits heparanase while displaying no major inhibition of human cytocrhome P450 isoenzymes. Displays antiangiogenic propertis in vitro. NÚMERO DE CAS 853929-59-6
Shikonin	sc-200391	A naphthoquinone derivative that has anti-inflammatory, anti-tumor properties, and can alter chemokine expression and function. Can inhibit proliferation and migration of endothelial cells. NÚMERO DE CAS 517-89-5	1
Thiolutin	sc-200387	Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. NÚMERO DE CAS 87-11-6
Tranilast	sc-200389	An angiogenesis inhibitor that also inhibits the release of histamine and prostaglandins from basophils and mast cells. Reported to inhibit leukotrienes, oxygen radicals, cyclooxygenase-2 expression, cytokines, collagen synthesis, and production of IL-1 and IL-2. NÚMERO DE CAS 53902-12-8
Tubulysin A	sc-222378	A cell-permeable atypical amino acid-containing peptide that acts as an anti-microtubule agent with potent antiproliferative and antiangiogenic properties. NÚMERO DE CAS 205304-86-5
Ursolic Acid	sc-200383	Ursolic Acid has been reported to be an anti-angiogenic and anti-proliferative compound. Also has been shown to induce cell cycle arrest and apoptosis. NÚMERO DE CAS 77-52-1
Tie2 Kinase Inhibidor	sc-356156	This compound is a cell-permeable pyridinylimidazole which has been reported to act as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2. This compound is reported to have selectivity over p38 MAPK, VEGFR2, VEGFR3, and PDGFR1β. Dem NÚMERO DE CAS 948557-43-5
Withaferin A	sc-200381	Shown to contain potent antiangiogenesis abilities. Also noted to be a proteasome and NFκB activation inhibitor. NÚMERO DE CAS 5119-48-2	8
Thalidomide	sc-201445	Thalidomide inhibits TNF alpha biosynthesis and bFGF-induced angiogenesis. Also induces apoptosis in human monocyte cultures, and suggested to inhibit HIV-1 replication. NÚMERO DE CAS 50-35-1	1
WEB-2086	sc-201007	WEB-2086 (Apafant) is a PAF-R (Platelet Activating Factor receptor) antagonist shown to have anticancer and cell differentiation effects. NÚMERO DE CAS 105219-56-5	3
HET-0016	sc-200673	HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. NÚMERO DE CAS 339068-25-6
bpV(pic)	sc-221379	A vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic.
MMP Inhibidor V	sc-203139	MMP Inhibitor V, also called ONO-4817 is an orally active non-peptidyl hydroxamate compound that inhibits a broad range of metalloproteinases (MMP). NÚMERO DE CAS 223472-31-9
Depudecin	sc-200651	Depudecin is a fungal metabolite that potently inhibits HDAC (histone deacetylase) activity in vitro. NÚMERO DE CAS 139508-73-9	2
GW 1929	sc-202640	GW 1929 is a potent, tyrosine-based peroxisome PPARγ (proliferator-activated receptor γ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). NÚMERO DE CAS 196808-24-9
Wortmannin	sc-3505	Wortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. NÚMERO DE CAS 19545-26-7	13
(+)­-Aeroplysinin-1	sc-202445	(+)-Aeroplysinin-1 displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity. NÚMERO DE CAS 28656-91-9
WZ 4002	sc-364655	WZ 4002 is a potent and selective EGFR inhibitor that blocks signal transduction at the cell surface, leading to apoptosis. NÚMERO DE CAS 1213269-23-8
Hypoestoxide, Hypoestes rosea	sc-221735	Hypoestoxide, Hypoestes rosea is a naturally occurring, cell-permeable diterpene with anti-inflammatory properties. A selective and direct IKK (IκB kinase) inhibitor. NÚMERO DE CAS 88498-46-8
SU1498	sc-355982	SU1498 is a potent ATP-competitive and selective inhibitor of Flk-1 (Flk-1 kinase), a vascular endothelial growth factor (VEGF) receptor kinase. Able to reduce expression of ets-1.
AG 1433 HCl	sc-221220	A specific and potent inhibitor of PDGF-β receptor kinase (IC550 = 5.0 µM) and of KDR/Flk-1/VEGF Receptor 2 (IC50 = 9.3 µM). Acts also as angiogenesis inhibitor.
D609	sc-201403	D609 is a selective inhibitor of phosphatidylcholine-specific PLC that also inhibits angiogenesis by preventing the synthesis of basement membrane. NÚMERO DE CAS 83373-60-8
SU 4312	sc-200637	SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR/Flk/Flt) inhibitor. NÚMERO DE CAS 5812-07-7
Thymoquinone	sc-215986	Thymoquinone is a phytochemical compound that acts as an angiogenesis inhibitor. Possesses potential analgesic, anticonvulsant, and anticancer properties. NÚMERO DE CAS 490-91-5