IgE Antibody (154/102): sc-53346

IgE Antibody (154/102) is a mouse monoclonal IgG1 kappa light chain antibody that detects the IgE protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-IgE antibody (154/102) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Immunoglobulin E (IgE) plays a crucial role in the immune system, particularly in mediating allergic responses and providing defense against parasitic infections. IgE is primarily located on the surface of basophils, mast cells, and activated eosinophils, where IgE binds to the Fc ε RI receptor. This binding is essential for the sensitization of mast cells, leading to the release of inflammatory mediators that trigger allergic reactions such as sneezing, itching, and swelling. Additionally, IgE′s interaction with parasites enhances the recruitment of eosinophils, which are vital for combating larger pathogens that cannot be engulfed by phagocytes. Understanding the function and location of IgE is important for developing targeted therapies for allergic diseases and improving our knowledge of immune responses to parasitic infections.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IgE Antibody (154/102) References:

1. Injection of anti-IgE antibodies will suppress IgE and allergic symptoms.  |  Patalano, F. 1999. Allergy. 54: 103-10. PMID: 10221432
2. Regulation of IgE-receptor expression, IgE occupancy and secretory capacity of mast cells.  |  Chen, XJ. and Enerbäck, L. 2000. APMIS. 108: 633-41. PMID: 11200817
3. The crystal structure of IgE Fc reveals an asymmetrically bent conformation.  |  Wan, T., et al. 2002. Nat Immunol. 3: 681-6. PMID: 12068291
4. The production and characterisation of a chimaeric human IgE antibody, recognising the major mite allergen Der p 1, and its chimaeric human IgG1 anti-idiotype.  |  Furtado, PB., et al. 2002. Mol Pathol. 55: 315-24. PMID: 12354937
5. Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE.  |  Wagner, B., et al. 2003. Vet Immunol Immunopathol. 92: 45-60. PMID: 12628763
6. Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells.  |  Karagiannis, SN., et al. 2003. Eur J Immunol. 33: 1030-40. PMID: 12672069
7. The beta subunit of the type I Fcepsilon receptor is a target for peptides inhibiting IgE-mediated secretory response of mast cells.  |  Andrásfalvy, M., et al. 2005. J Immunol. 175: 2801-6. PMID: 16116165
8. Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes.  |  Bundhoo, A., et al. 2015. Clin Exp Allergy. 45: 1085-98. PMID: 25652137
9. Improvement of the Elevated Tryptase Criterion to Discriminate IgE- From Non-IgE-Mediated Allergic Reactions.  |  Gastaminza, G., et al. 2018. Anesth Analg. 127: 414-419. PMID: 29189281
10. A rare case of the IgE prozone phenomenon in IgE multiple myeloma.  |  Chae, H., et al. 2022. Clin Biochem. 104: 59-61. PMID: 35131261
11. Self-reactive IgE and anti-IgE therapy in autoimmune diseases.  |  Olewicz-Gawlik, A. and Kowala-Piaskowska, A. 2023. Front Pharmacol. 14: 1112917. PMID: 36755957
12. Duplication and deletion in the human immunoglobulin epsilon genes.  |  Max, EE., et al. 1982. Cell. 29: 691-9. PMID: 6288268

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgE Antibody (154/102) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-IgE Antibody (154/102) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgE Antibody (154/102) Specifications

Alternate Product Name: IgE

Product Clone Name: 154/102

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: IgE

Epitope Species: human

Product Reactivity/Detection: IgE

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for IgE Antibody (154/102): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin