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- mouse monoclonal IgG1; 200 µg/ml
- raised against full length Cdc6 of human origin
- recommended for detection of Cdc6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- agarose conjugate for IP studies, sc-9964 AC, 500 µg/0.25 ml agarose
- HRP conjugate, sc-9964 HRP, 200 µg/ml
- fluorescein (sc-9964 FITC) and rhodamine (sc-9964 TRITC) conjugates for immunofluorescence, 200 µg/ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CDC6 |
990 |
17q21.2 |
NM_001254 |
Q99741
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602627 |
| Mouse |
Cdc6 |
23834 |
11 D |
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O89033
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N/A |
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Cdc6 Background Information
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division control (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein Tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory Tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (x complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.
| Cdc6 (180.2) Product Citations |
See how others have used Cdc6 (180.2): sc-9964 antibody and or Cdc6 (180.2) antibody conjugates.
29 total citations Loading citations.
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Cdc6 (180.2)
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Cdc6 (180.2): sc-9964. Western blot analysis of Cdc6 expression in HeLa nuclear extract.
Cdc6 (180.2): sc-9964. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tumor (A) and immunofluorescence staining of methanol-fixed HeLa cells (B) showing cytoplasmic staining.
Cdc6 (180.2): sc-9964. Western blot analysis of Cdc6 expression in HeLa whole cell lysate.
Cdc6 (180.2): sc-9964. Western blot analysis of Cdc6 expression in non-transfected 293T: sc-117752 (A), human Cdc6 transfected 293T: sc-173781 (B) and Jurkat (C) whole cell lysates. |
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