SAP 97 Background Information The discs large (dlg) tumor suppressor gene was first identified in Drosophila through genetic analysis of germline mutations. Several mammalian homologs were subsequently identified and categorized into a protein family designated MAGUK (membrane-associated guanylate kinase homolog). The mammalian homolog of dlg, SAP 97, is also known as hdlg-1 (human) and NE-dlg (neuronal and endocrine). The rat synaptic protein SAP 90 (also designated PSD-95) also shares homology with these proteins. MAGUKs are localized at the membrane-cytoskeleton interface and contain several distinct domains which suggest a role for these proteins in intracellular signal transduction. Interaction of hdlg-1 and NE-dlg with the tumor suppresor protein APC suggest that MAGUK proteins may also play a role in regulation of growth.
SAP 97 (2D11) Product Citations
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SAP 97 (2D11)
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SAP 97 (2D11): sc-9961. Western blot analysis of SAP 97 expression in MCF7 (A) and HeLa (B) whole cell lysates.
SAP 97 (2D11): sc-9961. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic and membrane staining of cells in tubules (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
SAP 97 (2D11): sc-9961. Western blot analysis of SAP 97 expression in Caco-2 whole cell lysate.
SAP 97 (2D11): sc-9961. Western blot analysis of SAP 97 expression in mouse eye tissue extract.
SAP 97 (2D11): sc-9961. Western blot analysis of SAP 97 expression in SKBR-3 whole cell lysate.
