TFII-I (V-18) Antibody: sc-9943

TFII-I Background Information
Initiation of transcription of eukaryotic genes requires the association of large multimeric protein complexes that involve RNA polymerase II and a variety of basal transcription factors, including members of the TFII protein family (1,2). TFII proteins complex with Pol II and initiate transcription by binding to the core promoter elements, such as TATA box sequences, that are located upstream of the transcription start codon (3). A member of the TFII family, TFII-I is regulated by tyrosine phophorylation, and it is involved in the initiation of transcription of TATA-less promoters and in cell type specific transcription (4). TFII-I directly associates with several promoters elements, including TATA box, pyrimidine-rich initiator (Inr) and E-box elements (5). TFII-I is also implicated in activating transcription of the transcription factor c-fos, a downstream effector protein in the MAP kinase-signaling pathway (6). TFII-I binds to several initiation sites within the c-fos promoter, and it is phosphorylated in response to Map kinase activation, which then enhances TFII-I induced expression of c-fos (7,8).