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CNG-β3 Antibody (M-224): sc-99179

 |  Datasheet

(Based on data analysis)
  • CNG-β3 Antibody (M-224) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 1-224 mapping at the N-terminus of CNG-β3 of mouse origin
  • recommended for detection of CNG-β3 of mouse and rat origin by WB, IP, IF and ELISA
 
Full-length CNG-β3 protein sequence with immunogen highlighted:
MLKSLTVKFNKVNPMEGRMEKKLCPNLSSLSQPTIAQGDNQSEKEPLRSRTPITFEKSHSKEDNSTGENSLRDFTPNPDPECRAELTRTMAEMEKTRTGKERPVSFKTKVLETSIINEYTDAHLHNLVERMRERTALYKKTLTEEENFPEVEASSQTAMSTNISPKQENNSKLKEHQDTFSFKPQRVPVKEHLRRMILPRSIDSYTDRVYLLWLLLVTIAYNWCWLLPVRLVFPCQTPDNKNYWIITDIVCDIIYLCDILLIQPRLQFVRGGEIIVDSNELKRNYRSSTKFRMDVASLLPFEVLYIFFGVNPIFRANRILKYTSFFEFNHHLESIMDKAYVYRVIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYWAVRTLITIGGLPEPQTSFEIVFQFLNFFSGVFVFSSLIGQMRDVIGAATANQNYFQACMDHIIAYMNKYSIPQSVQYRVRTWLEYTWNSQRILDESNLLENLPTAMQLSIALDINFSIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGSVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKILLSQKGKTTQAIPARPGPAFLFPPKEETPRMLKVLLGNTGKVDLGRLLKGKRKTTTQK

See additional CNG Antibodies including CNG, CNG-1, CNG-1beta, CNG-2, CNG-3, CNG-beta 3 and CNG-4.

Also see CNG Activators for functional analysis of cellular responses to CNG.


Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3 Antibody (M-224) sc-99179 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3 siRNA (m) sc-45564 10 µM $258
CNG-β3siRNA (m)-PR sc-45564-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3siRNA shRNA Plasmid (m) sc-45564-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CNG-β3siRNA shRNA (m) Lentiviral Particles sc-45564-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Cngb3 30952 4 A3 Q9JJZ9
 N/A
 

Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits. The alpha (å) subunits consist of CNG1-3 and form functional cation channels by themselves. The beta (∫) subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels. formed by CNG1-3. CNG channels are essential components of olfactory and visual transduction. CNG proteins are present in cone and rod photoreceptors and in the pineal gland, and they contribute to modulating arterial blood pressure. CNG6, also designated cyclic-nucleotide-gated cation channel beta 3 (CNG-∫3), is an integral membrane protein that can form a heterooligomeric complex with CNG-3. CNG-∫3 is activated by cGMP and this activation leads to the depolarization of rod photoreceptors as a result of cation channel being opened. CNG-∫3 is expressed in a small group of retinal photoreceptor cells and in testis. Mutations in the gene encoding for CNG-∫3, can cause achromatopsia, an autosomal recessively inherited disease characterized by low visual acuity, photophobia, a lack of color discrimination, and nystagmus.