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IL-1RAcP Antibody (H-128): sc-99031

 |  Datasheet

(Based on data analysis)
  • IL-1RAcP Antibody (H-128) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 221-348 mapping within an internal region of IL-1RAcP of human origin
  • recommended for detection of IL-1RAcP of mouse, rat and human origin by WB, IP, IF and ELISA
 
Full-length IL-1RAcP protein sequence with immunogen highlighted:
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV

See additional IL-1R Antibodies including IL-1R, IL-1ra, IL-1RAcP, IL-1RI, IL-1RII, IL-1Rrp2, IL-1R8 and IL-1R9.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
IL-1RAcP Antibody (H-128) sc-99031 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IL-1RAcP siRNA (h) sc-60831 10 µM $258
IL-1RAcP siRNA (m) sc-60832 10 µM $258
IL-1RAcP (h)-PR sc-60831-PR 10 µM, 20 µl $23
IL-1RAcP (m)-PR sc-60832-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IL-1RAcP shRNA Plasmid (h) sc-60831-SH 20 µg $520
IL-1RAcP shRNA Plasmid (m) sc-60832-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
IL-1RAcP shRNA (h) Lentiviral Particles sc-60831-V 200 µl $625
IL-1RAcP shRNA (m) Lentiviral Particles sc-60832-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human IL1RAP 3556 3q28 Q9NPH3
 602626
 

Interleukin-1 (IL-1) is a key pro-inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL-1å and IL-1∫, bind to a single known functional type-1 IL-1 receptor (IL-1RI), which associates with the accessory protein (IL-1RAcP), resulting in signal transduction. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1RAcP to activate NF˚B. The membrane bound form of IL-1RAcP (mIL-1RAcP) facilitates signal transduction. Two alternatively spliced isoforms, soluble IL-1RAcP (sIL-1RAcP) and sIL-1RAcP-∫, which lack transmembrane and intracellular domains, can inhibit IL-1 signaling. Although both mIL-1RAcP and sIL-1RAcP mRNAs are widely expressed in human tissue, their relative proportions differ significantly in a tissue-specific manner.