epitope corresponding to amino acids 225-410 mapping within a C-terminal cytoplasmic domain of SIGIRR of human origin
recommended for detection of SIGIRR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine and porcine
SIGIRR Background Information Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut.
SIGIRR (H-186)
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SIGIRR (H-186): sc-98976. Western blot analysis of SIGIRR expression in HeLa whole cell lysate.
SIGIRR (H-186): sc-98976. Western blot analysis of SIGIRR expression in A549 whole cell lysate.
