epitope corresponding to amino acids 223-268 mapping within an internal region of ICA69 of human origin
recommended for detection of ICA69 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
ICA69 Background Information Pancreatic islet cells are clusters of endocrine cells that are scattered throughout the tissue of the pancreas and secrete insulin and glucagon, which help the body store and use sugars. Each islet contains approximately 1,000 cells and is 50-500 µm in diameter. Islet cell autoantigen 1, also designated ICA69 or p69 protein, is an environmental trigger molecule that induces diabetic autoimmunity to insulin producing islet cells. The human ICA1 gene maps to chromosome 7p22 and generates three transcript variants that encode the T cell epitope (in exon 2) that is detectable by autoreactive T cells in diabetic children. Human ICA69 transcript is abundant in pancreas, brain and heart, with lower levels of expression found in lung, liver, thyroid and kidney.
