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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-9863-R
- epitope mapping within an internal region of PML of human origin
- recommended for detection of all isoforms of PML of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-9863 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-9863 X, 200 µg/0.1 ml
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PML Background Information
The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal translocation of the retinoic acid receptor å (RARå) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARa chimeric protein. Myeloid precursor cells expressing the PML/RARå chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RARå transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/RARå also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.
| PML (A-20) Product Citations |
See how others have used PML (A-20): sc-9863 antibody and or PML (A-20) antibody conjugates.
7 total citations Loading citations.
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PML (A-20)
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PML (A-20): sc-9863. Western blot analysis of 69 kDa PML expression in mouse lymph node tissue extract.
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