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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of MCM6 of human origin
- recommended for detection of MCM6 of mouse, rat and human origin by WB, IP, IF, IHC(P), ELISA and indirect FCM using FITC-conjugated donkey anti-goat IgG: sc-2024; also reactive with additional species, including equine, canine and bovine
- blocking peptide, sc-9843 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
MCM6 |
4175 |
2q21.3 |
NM_005915 |
Q14566
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n/a |
| Mouse |
Mcm6 |
17219 |
1 E4 |
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P97311
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N/A |
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MCM6 Background Information
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation during apoptosis of the MCM complex, which is composed of, at least, MCM2–6. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity, and MCM5 is involved in IFN-©-induced Stat1å transcription activation.
| MCM6 (C-20) Product Citations |
See how others have used MCM6 (C-20): sc-9843 antibody and or MCM6 (C-20) antibody conjugates.
13 total citations Loading citations.
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MCM6 (C-20)
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MCM6 (C-20): sc-9843. Western blot analysis of MCM6 expression in MM-142 (A), KNRK (B), NIH/3T3 (C), Jurkat (D) and K-562 (E) whole cell lysates.
MCM6 (C-20): sc-9843. Immunofluorescence staining of methanol-fixed K-562 cells showing nuclear staining.
MCM6 (C-20): sc-9843. Indirect, intracellular FCM analysis of fixed and permeabilized K-562 cells stained with MCM6 (C-20), followed by FITC-conjugated donkey anti-goat IgG: sc-2024. Black line histogram represents the isotype control, normal goat IgG: sc-3887. MCM6 siRNA (h): sc-35885. Western blot analysis of MCM6 expression in non-transfected control (A) and MCM6 siRNA transfected (B) HeLa cells. Blot probed with MCM6 (C-20): sc-9843. α-actinin (H-2): sc-17829 used as specificity and loading control. |
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