epitope mapping within an internal region of NANP of human origin
recommended for detection of NANP of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, bovine and porcine
NANP Background Information Sialic acids are a family of 9-carbon 2-keto-3-deoxy sugars that are found on the ends of glycoproteins and glycolipids and play important roles in recognition events within the cell. Playing an important role in cell-cell and protein-protein recognition, N-acetylneuraminate is the main form of sialic acid in vertebrates. NANP (N-acylneuraminate-9-phosphatase), also known as HDHD4 (Haloacid dehalogenase-like hydrolase domain-containing protein 4), is a 248 amino acid protein that belongs to the haloacid dehalogenase (HAD) family and is responsible for dephosphorylating Neu5Ac-9-phosphate to form N-acetylneuraminate. Characteristic of the HAD phosphatase family, the catalytic activity of NANP is dependent upon the presence of magnesium and is inhibited by vanadate and calcium.
NANP (P-17)
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NANP (P-17): sc-98024. Western blot analysis of NANP expression in non-transfected: sc-117752 (A) and human NANP transfected: sc-177597 (B) 293T whole cell lysates.
