Dynactin 1 Background Information
Dynactin, a multisubunit complex, is a cytoplasmic Dynein-interacting protein that functions as the ”receptor” for the Dynein microtubule motor. Dynactin/ Dynein binding may be required for most, if not all, cytoplasmic Dynein-driven activities and is thought to contribute to the functional diversity of Dynein. Enriched in neurons, Dynactin also binds to microtubules and has been shown to function in diverse processes, including organelle transport, formation of the mitotic spindle and cytokinesis. Dynactin subunits include p22, p50, p62, p150 (also designated Glued) and ARP-1. The p135 splice variant is neuron specific and, unlike p150, does not bind microtubules.
