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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of ETO-2 of human origin
- recommended for detection of ETO-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- blocking peptide, sc-9739 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-9739 X, 200 µg/0.1 ml
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ETO-2 Background Information
ETO and ETO-2, which are alternatively designated MTG8 and MTG16, respectively, are members of the ETO transcription factor family. These transcription factors are characterized by a zinc-finger domain and four conserved domains, of which domain II is required for dimerization between family members. ETO and ETO-2 may function to mediate interactions between DNA binding proteins and transcriptional regulators, such as N-CoR. Frequently, the t(8;21) translocation of ETO produces the AML-1/ETO oncoprotein, which consists of the first 177 amino acids of AML-1 and all but the first 30 amino acids of ETO. AML-1/ETO expression is observed in 12–15% of acute myelogenous, M2 subtype leukemias. The AML-1/ETO fusion proteins associate with multimeric N-CoR/mSin3/HDAC1 complexes, block differentiation and induce transcriptional repression by altering chromatin remodeling.
| ETO-2 (C-20) Product Citations |
See how others have used ETO-2 (C-20): sc-9739 antibody and or ETO-2 (C-20) antibody conjugates.
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ETO-2 (C-20)
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ETO-2 (C-20): sc-9739. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil showing nuclear staining.
ETO-2 (C-20): sc-9739. Western blot analysis of ETO-2 expression in non-transfected: sc-117752 (A) and human ETO-2 transfected: sc-116819 (B) 293T whole cell lysates. |
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