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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of ETO of human origin
- recommended for detection of ETO of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, porcine and avian
- blocking peptide, sc-9736 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-9736 X, 200 µg/0.1 ml
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ETO Background Information
ETO and ETO-2, which are alternatively designated MTG8 and MTG16, respectively, are members of the ETO transcription factor family. These transcription factors are characterized by a zinc-finger domain and four conserved domains, of which domain II is required for dimerization between family members. ETO and ETO-2 may function to mediate interactions between DNA binding proteins and transcriptional regulators, such as N-CoR. Frequently, the t(8;21) translocation of ETO produces the AML-1/ETO oncoprotein, which consists of the first 177 amino acids of AML-1 and all but the first 30 amino acids of ETO. AML-1/ETO expression is observed in 12–15% of acute myelogenous, M2 subtype leukemias. The AML-1/ETO fusion proteins associate with multimeric N-CoR/mSin3/HDAC1 complexes, block differentiation and induce transcriptional repression by altering chromatin remodeling.
| ETO (S-19) Product Citations |
See how others have used ETO (S-19): sc-9736 antibody and or ETO (S-19) antibody conjugates.
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ETO (S-19)
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ETO (S-19): sc-9736. Western blot analysis of ETO expression in AML-193 (A), CCRF-CEM (B), CCRF-HSB-2 (C), HL-60 (D), HuT 78 (E) and MOLT-4 (F) whole cell lysates.
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