epitope mapping near the C-terminus of Six1 of human origin
recommended for detection of Six1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and porcine
blocking peptide, sc-9709 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-9709 X, 200 µg/0.1 ml
Six1 Background Information The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. SIX2, SIX4 (AREC3) and SIX5 bind to the same DNA sequence, indicating that they may regulate the same target genes. SIX1 and SIX4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint.
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Six1 (A-20)
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Six1 (A-20): sc-9709. Western blot analysis of Six1 expression in non-transfected: sc-117752 (A) and mouse Six1 transfected: sc-123562 (B) 293T whole cell lysates.
