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Mcl-1L Antibody (K-20): sc-958

 |  Datasheet

(Based on data analysis)

  • Mcl-1L Antibody (K-20) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of Mcl-1L of human origin
  • recommended for detection of Mcl-1 long form of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-958 P
  • See 11 citations for Mcl-1L Antibody (K-20)
 

See additional Mcl-1 Antibodies.

Also see Mcl-1 Inhibitors for functional analysis of cellular responses to Mcl-1.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Mcl-1L Antibody (K-20) sc-958 200 µg/ml $279
Mcl-1L (K-20) P sc-958 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Mcl-1L siRNA (h) sc-43912 10 µM $258
Mcl-1L (h)-PR sc-43912-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Mcl-1L shRNA Plasmid (h) sc-43912-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Mcl-1L shRNA (h) Lentiviral Particles sc-43912-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
BJAB Whole Cell Lysate sc-2207 500 µg/200 µl $104
Ramos Cell Lysate sc-2216 500 µg/200 µl $104
JAR Cell Lysate sc-2276 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MCL1 4170 1q21.2 NM_021960, NM_182763 Q07820
 159552
Mouse Mcl1 17210 3 F2.1 P97287
 N/A
 

B cell cll/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice. The Mcl-1 mRNA is alternatively spliced into a long and a short form of the protein, designated Mcl-1L and Mcl-1S, respectively. Mcl-1S, unlike Mcl-1L, does not interact with proapoptotic Bcl-2-related proteins.

Mcl-1L Antibody (K-20) Product Citations
See how others have used Mcl-1L Antibody (K-20) and or Mcl-1L Antibody (K-20) conjugates.


11 total citations
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Mcl-1L Antibody (K-20) Data
Click on image to enlarge
sc-958
Mcl-1L (K-20): sc-958. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of decidual cells.
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