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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of FHL-5 of mouse origin
- recommended for detection of FHL-5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-9369 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-9369 X, 200 µg/0.1ml
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Ordering Information
Recommended Support Products:
(click button of application of choice)
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
Fhl5 |
57756 |
4 A3 |
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Q9WTX7
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| Mouse |
Fhl5 |
57756 |
4 A3 |
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Q9WTX7
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N/A |
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FHL-5 Background Information
The four-and-a-half-LIM domain (FHL) proteins include FHL-1 (SLIM1), FHL-2 (SLIM3), FHL-3 (SLIM2), FHL-4 and FHL-5. The signature “half-domain”, a single zinc finger domain located in the N-terminal region, differentiates FHLs from other LIM-only proteins, which have numbers of zinc fingers. Specific combinations of FHL proteins elicit selective activation of both CREB and CREM. FHL-5, also known as ACT (Activator of CREM in Testis), is a testis-specific protein that interacts with CREM (a transcription factor required for spermatid differentiation) via its third LIM domain and can stimulate CREM activity independently of phosphorylation. This suggests that FHL-5 may participate in the regulation of spermatogenesis by acting as a transcriptional coactivator of CREM. During spermatid elongation, FHL-5 is translocated from the nucleus to the cytoplasm by the kinesin motor protein KIF17 thus silencing CREM activity. |
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FHL-5 (S-18)
Click on image to enlarge
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FHL-5 (S-18): sc-9369. Western blot analysis of FHL-5 expression in PC-3 whole cell lysate.
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