Gab 2 (M-19) Antibody: sc-9313

Gab 2 Background Information
Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectabekm 181 iqvvdeidsi ttlpdltplf isidperdtk eaianyvkef spklvgltgt reevdqvara 241 yrvle catalytic activity (1-3,8). These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate (4-7). Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. The Gap 1 related protein, Gab 2, associates with SH2 domain-containing proteins, such as SHP2, and it is involved in a novel pathway for cytokine-induced gene activation (8).