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home » Transcription Regulators » TRF Antibody / TRF Antibodies » TRF2 (H-300): sc-9143

TRF2 (H-300) Antibody: sc-9143

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 49-300 of TRF2 of human origin
  • recommended for detection of TRF2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine, bovine and porcine
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TERF2 7014 16q22.1 NM_005652 Q15554
 602027
Mouse Terf2 21750 8 D3 O35144
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TRF2 (H-300) sc-9143 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TRF2 siRNA (h) sc-38505 10 µM $258
TRF2 siRNA (m) sc-38506 10 µM $258
TRF2 (h)-PR sc-38505-PR 10 µM $23
TRF2 (m)-PR sc-38506-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TRF2 shRNA Plasmid (h) sc-38505-SH 20 µg $520
TRF2 shRNA Plasmid (m) sc-38506-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TRF2 shRNA (h) Lentiviral Particles sc-38505-V 200 µl $625
TRF2 shRNA (m) Lentiviral Particles sc-38506-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
TRF2 (h): 293T Lysate sc-113675 100µg/200µl $205
NAMALWA Cell Lysate sc-2234 500 µg/200 µl $104
K-562 nuclear extract sc-2130 1000 µg $143
Jurkat nuclear extract sc-2132 1000 µg $143
HeLa nuclear extract sc-2120 1000 µg $143

TRF2 Background Information
Telomeric repeat binding factor 1 (TERF1, PIN2, TRF1, TRBF1) and telomeric repeat binding factor 2 (TERF2, TRF2, TRBF2) are present at telomeres throughout the cell cycle, where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of 5'-TTAGGG-3' to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis.

TRF2 (H-300) Product Citations
See how others have used TRF2 (H-300): sc-9143 antibody and or TRF2 (H-300) antibody conjugates.


16 total citations
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TRF2 (H-300)
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sc-9143
TRF2 (H-300): sc-9143. Western blot analysis of TRF2 expression in NAMALWA whole cell lysate.
sc-9143
TRF2 (H-300): sc-9143. Western blot analysis of TRF2 expression in HeLa (A), K-562 (B) and Jurkat (C) nuclear extracts.
sc-9143
TRF2 (H-300): sc-9143. Western blot analysis of TRF2 expression in K-562 nuclear extract.
sc-9143
TRF2 (H-300): sc-9143. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing nuclear staining of lymphoid cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-9143
TRF2 (H-300): sc-9143. Western blot analysis of TRF2 expression in HeLa whole cell lysate.
sc-9143
TRF2 (H-300): sc-9143. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.
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