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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-425 of IRF-3 of human origin
- recommended for detection of IRF-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-9082 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
IRF3 |
3661 |
19q13.33 |
NM_001571 |
Q14653
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n/a |
| Mouse |
Irf3 |
54131 |
7 B4 |
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P70671
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N/A |
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IRF-3 Background Information
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-å and ∫) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-å and interferon-∫ genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3© p48 and IFN consensus sequence-binding protein (ICSBP).
| IRF-3 (FL-425) Product Citations |
See how others have used IRF-3 (FL-425): sc-9082 antibody and or IRF-3 (FL-425) antibody conjugates.
79 total citations Loading citations.
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IRF-3 (FL-425)
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IRF-3 (FL-425): sc-9082. Western blot analysis of IRF-3 expression in HeLa (A), Jurkat (B) and HL-60 (C) whole cell lysates.
IRF-3 (FL-425): sc-9082. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
IRF-3 (FL-425): sc-9082. Western blot analysis of IRF-3 expression in non-transfected 293T: sc-117752 (A), human IRF-3 transfected 293T: sc-117389 (B) and HeLa (C) whole cell lysates. IRF-3 (FL-425): sc-9082. Western blot analysis of IRF-3 expression in non-transfected: sc-117752 (A) and human IRF-3 transfected: sc-176308 (B) 293T whole cell lysates. IRF-3 (FL-425): sc-9082. Western blot analysis of IRF-3 expression in HeLa (A), HL-60 (B), Jurkat (C), Hep G2 (D), MCF7 (E) and PC-3 (F) whole cell lysates.
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