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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 80-284 mapping within an internal region of HNF-1α of human origin
- recommended for detection of HNF-1α and HNF-1β of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-8986 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HNF1A |
6927 |
12q24.31 |
NM_000545 |
P20823
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600496 |
| Mouse |
Hnf1a |
21405 |
5 F |
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P22361
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N/A |
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HNF-1 Background Information
HNF-1 (å and ∫), HNF-3 (å, ∫ and ©), HNF-4 (å and ©), and HNF-6 compose, in part, a homoeprotein family designated the Hepatocyte Nuclear Factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3å, HNF-3∫ and HNF-3© regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3å and HNF-3∫ have also been shown to be involved in gastrulation events such as body axis formation. HNF-4å and HNF-4© have been shown to be important for early embryo development. HNF-4å is expressed in liver, kidney, pancreas, small intestine, testis and colon; and HNF-4© is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3∫, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and å-1 antitrypsin.
| HNF-1 (H-205) Product Citations |
See how others have used HNF-1 (H-205): sc-8986 antibody and or HNF-1 (H-205) antibody conjugates.
17 total citations Loading citations.
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HNF-1 (H-205)
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HNF-1 (H-205): sc-8986. Western blot analysis of HNF-1 expression in Hep G2 whole cell lysate.
HNF-1 (H-205): sc-8986. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing nuclear staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
HNF-1 (H-205): sc-8986. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing nuclear staining of cells in tubules.
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