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home » Transcription Regulators » HMG Antibody / HMG Antibodies » HMG-I/HMG-Y (FL-95): sc-8982

HMG-I/HMG-Y (FL-95) Antibody: sc-8982

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-95 representing full length HMG Y of human origin
  • recommended for detection of HMG-I and HMG-Y of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine, bovine and porcine
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-8982 X, 200 µg/0.1 ml
 
Additional HMG Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human HMGA1 3159 6p21.31 NM_002131, NM_145899, NM_145901, NM_145902, NM_145903, NM_145904, NM_145905 P17096
 600701
Mouse Hmga1 15361 17 A3.3 P17095
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HMG-I/HMG-Y (FL-95) sc-8982 200 µg/ml $279
HMG-I/HMG-Y (FL-95) sc-8982 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HMG-I/HMG-Y siRNA (h) sc-37115 10 µM $258
HMG-I/HMG-Y siRNA (m) sc-37116 10 µM $258
HMG-I/HMG-Y (h)-PR sc-37115-PR 10 µM $23
HMG-I/HMG-Y (m)-PR sc-37116-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HMG-I/HMG-Y shRNA Plasmid (h) sc-37115-SH 20 µg $520
HMG-I/HMG-Y shRNA Plasmid (m) sc-37116-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HMG-I/HMG-Y shRNA (h) Lentiviral Particles sc-37115-V 200 µl $625
HMG-I/HMG-Y shRNA (m) Lentiviral Particles sc-37116-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse spleen extract sc-2391 500 µg/200 µl $104

HMG-I/HMG-Y Background Information
High mobility group (HMG) I (Y) chromatin proteins bind to the minor groove of AT-rich DNA sequences with high affinity. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG I (Y) contains two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

HMG-I/HMG-Y (FL-95) Product Citations
See how others have used HMG-I/HMG-Y (FL-95): sc-8982 antibody and or HMG-I/HMG-Y (FL-95) antibody conjugates.


7 total citations
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HMG-I/HMG-Y (FL-95)
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sc-8982
HMG-I/HMG-Y (FL-95): sc-8982. Western blot analysis of HMG-I/HMG-Y expression in non-transfected: sc-117752 (A) and mouse HMG-I/HMG-Y transfected: sc-120837 (B) 293T whole cell lysates and mouse spleen tissue extract (C).
sc-8982
HMG-I/HMG-Y (FL-95): sc-8982. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing nuclear staining of tropho-blastic cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-8982
HMG-I/HMG-Y (FL-95): sc-8982. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing nuclear and cytoplasmic staining of glandular cells.
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