epitope mapping at the N-terminus of VDAC1 of human origin
recommended for detection of VDAC1 and, to a lesser extent, VDAC2 and VDAC3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
VDAC1 Background Information Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential.
VDAC1 (N-18) Product Citations
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VDAC1 (N-18)
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VDAC1 (N-18): sc-8828. Western blot analysis of VDAC1 expression in rat heart extract.
