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DNA pol δ 2 (C-20) Antibody: sc-8800 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of DNA pol δ 2 of human origin
- recommended for detection of DNA pol δ 2 of human origin by WB, IP, IF and ELISA
; also reactive with additional species, including equine, canine and bovine
- blocking peptide, sc-8800 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
POLD2 |
5425 |
7p13 |
NM_006230 |
P49005
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600815 |
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DNA pol δ 2 Background Information
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). Exonucleases involved in these processes include DNA polymerases, including DNA pol ∂ and é. DNA pol ∂ consists of two subunits, p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50 (3,4). DNA pol ∂ can be regulated by cell cycle proteins (5). DNA pol é is a multiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene (6,7). The exact reactions catalyzed by DNA pol ∂ and é on leading and lagging strands have not yet been elucidated.
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DNA pol δ 2 (C-20)
Click on image to enlarge
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DNA pol δ 2 (C-20): sc-8800. Western blot analysis of DNA pol δ 2 expression in Jurkat nuclear extract.
DNA pol δ 2 (C-20): sc-8800. Western blot analysis of DNA pol δ 2 expression in non-transfected 293T: sc-117752 (A), human DNA pol δ 2 transfected 293T: sc-172631 (B) and HeLa (C) whole cell lysates. |
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