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DNA pol δ cat (C-20) Antibody: sc-8797 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of DNA pol δ cat of human origin
- recommended for detection DNA pol δ catalytic chain of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-8797 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
POLD1 |
5424 |
19q13.33 |
NM_002691 |
P28340
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174761 |
| Mouse |
Pold1 |
18971 |
7 B4 |
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P52431
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N/A |
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DNA pol δ cat Background Information
DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). Exonucleases involved in these processes include DNA polymerases, including DNA pol ∂ and é. DNA pol ∂ consists of two subunits, p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50 (3,4). DNA pol ∂ can be regulated by cell cycle proteins (5). DNA pol é is a multiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene (6,7). The exact reactions catalyzed by DNA pol ∂ and é on leading and lagging strands have not yet been elucidated.
| DNA pol δ cat (C-20) Product Citations |
See how others have used DNA pol δ cat (C-20): sc-8797 antibody and or DNA pol δ cat (C-20) antibody conjugates.
8 total citations Loading citations.
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DNA pol δ cat (C-20)
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Western blot analysis of DNA pol δ cat expression in NIH/3T3 nuclear extract (A) and DNA pol ζ expression in K-562 (B) and Jurkat (C) nuclear extracts. Antibodies tested include DNA pol δ cat (C-20): sc-8797 (A) and DNA pol ζ (N-20): sc-5939 (B,C). DNA pol δ cat (C-20): sc-8797. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
DNA pol δ cat (C-20): sc-8797. Western blot analysis of DNA pol δ cat expression in non-transfected: sc-117752 (A) and human DNA pol δ cat transfected: sc-170437 (B) 293T whole cell lysates. DNA pol δ cat (C-20): sc-8797. Western blot analysis of DNA pol δ cat expression in non-transfected: sc-117752 (A) and human DNA pol δ cat transfected: sc-170293 (B) 293T whole cell lysates. |
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