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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of TTF-1 of human origin
- recommended for detection of TTF-1 and NKX2-4 human and mouse origin and TTF-1 of rat origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-8761 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-8761 X, 200 µg/0.1 ml
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Ordering Information
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TTF-1 Background Information
TTF-1 (thyroid transcription factor-1, BCH, BHC, NK-2, Nkx2.1, Nkx2A, TEBP, TTF1) is a member of the Nkx2 family of homeodomain-containing transcription factors and regulates the transcriptional activity of thyroid-specific genes. TTF-1 influences organogenisis and the maintenance of the differentiated phenotypes of various tissues including thyroid, lung and brain. TTF-1, which is present in the epithelium of the lung, regulates transcription of the surfactant proteins (SP) A, B and C and is essential for lung morphogenesis. In the thyroid, TTF-1 elevates the expression of thyroid specific markers, thyroglobulin, thyroperoxidase and thyrotropin receptors. TTF-1 interacts with SRC-1 and CBP in vitro. |
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TTF-1 (N-19)
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TTF-1 (N-19): sc-8761. Western blot analysis of TTF-1 expression in non-transfected: sc-117752 (A) and human TTF-1 transfected: sc-159187 (B) 293T whole cell lysates. |
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