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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of HAT1 of human origin
- recommended for detection of HAT1 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-8752 P
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HAT1 Background Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.
| HAT1 (C-20) Product Citations |
See how others have used HAT1 (C-20): sc-8752 antibody and or HAT1 (C-20) antibody conjugates.
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HAT1 (C-20)
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HAT1 (C-20): sc-8752. Western blot analysis of HAT1 expression in HeLa (A) and BT-20 (B) whole cell lysates and A-431 (C) and HeLa (D) nuclear extracts.
HAT1 (C-20): sc-8752. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.
HAT1 (C-20): sc-8752. Western blot analysis of HAT1 expression in non-transfected 293T: sc-117752 (A), human HAT1 transfected 293T: sc-116753 (B) and HeLa (C) whole cell lysates. |
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