epitope mapping at the N-terminus of Brg-1 of human origin
recommended for detection of Brg-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and avian
blocking peptide, sc-8749 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-8749 X, 200 µg/0.1 ml
Brg-1 Background Information The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2å) and Brg-1 (also designated SNF2ß) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
Brg-1 (N-15) Product Citations
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Brg-1 (N-15)
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Brg-1 (N-15): sc-8749. Western blot analysis of Brg-1 expression in K-562 (A) and HeLa (B) nuclear extracts.
