epitope mapping at the C-terminus of Tiam1 of mouse origin
recommended for detection of Tiam1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, porcine and avian
Tiam1 Background Information A gene designated Tiam1 was originally identified as an invasion-inducing gene by proviral tagging in combination with in vitro selection for invasiveness. Transfection of truncated Tiam1 cDNAs into noninvasive cells made these cells invasive. The predicted Tiam1 protein exhibits both Dbl and Pleckstrin-homologous domains characteristic of GDP-GTP exchange proteins for Rho-like proteins that have been implicated in cytoskeletal organization. In fibroblasts, Tiam1 induces a phenotype similar to that of constitutively activated (V12) Rac1, including membrane ruffling, and this is inhibited by dominant negative (N17) Rac1. Moreover, T lymphoma cells expressing (V12) Rac1 become invasive, supporting the suggestion that the Tiam1-Rac signaling pathway may be involved in the invasion and metastasis of tumor cells.
Tiam1 (C-16) Product Citations
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Tiam1 (C-16)
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Tiam1 (C-16): sc-872. Western blot analysis of Tiam1 expression in NIH/3T3 whole cell lysate.
Tiam1 (C-16): sc-872. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
